Prognostic value of transforming growth factor beta 1 [TGF-β1] and matrix metalloproteinase 9 [MMP-9] in oral squamous cell carcinoma

Elahi, Maryam; Rakhshan, Vahid; Ghasemian, Nasim Taghavi; Moshref, Mohamad

doi:10.3109/1354750x.2011.635804

Cited by 36 publications

(40 citation statements)

References 25 publications

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“…[22][23][24][25] Hernández-Pérez et al [26] found that MMP-14 may be used as a prognosticator in SCC while MMP-2 may be of relevance to tumor progression.…”

Section: Discussionmentioning

confidence: 98%

Role of Cyclooxygenase-2, Ezrin and Matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma

El‐Khalawany

Abou-Bakr

2013

J Can Res Ther

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“…[22][23][24][25] Hernández-Pérez et al [26] found that MMP-14 may be used as a prognosticator in SCC while MMP-2 may be of relevance to tumor progression.…”

Section: Discussionmentioning

confidence: 98%

Role of Cyclooxygenase-2, Ezrin and Matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma

El‐Khalawany

Abou-Bakr

2013

J Can Res Ther

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“…64,65 Wingless-type MMTV integration site family member 5B (WNT5B) knockdown suppresses MMP-10 production and invasion indicating that the WNT signaling pathways can also contribute to invasion. 66,67 Transforming growth factor b (TGFb) can be produced by tumor-associated fibroblasts 68 and induce NF-jB activation 69 and SMAD-dependent MMP production, 70 as well as epithelial to mesenchymal transition (EMT) factors, such as Snail and Slug. [71][72][73][74][75][76] Invasion is stimulated by hypoxia in a Notch-dependent fashion.…”

Section: Cell Surface Receptors Influence Invasivementioning

confidence: 99%

Mechanisms of Invasion in Head and Neck Cancer

Jimenez¹,

Jayakar²,

Ow³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The highly invasive properties demonstrated by head and neck squamous cell carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node metastasis in patients and is a key factor leading to an expected 5-year survival rate of approximately 50% for patients with advanced disease. It is important to understand the features and mediators of HNSCC invasion so that new treatment approaches can be developed.Objectives.-To provide an overview of the characteristics, mediators, and mechanisms of HNSCC invasion.Data Sources.-A literature review of peer-reviewed articles in PubMed on HNSCC invasion.Conclusions.-Histologic features of HNSCC tumors can help predict prognosis and influence clinical treatment decisions. Cell surface receptors, signaling pathways, proteases, invadopodia function, epithelial-mesenchymal transition, microRNAs, and tumor microenvironment are all involved in the regulation of the invasive behavior of HNSCC cells. Identifying effective HNSCC invasion inhibitors has the potential to improve outcomes for patients by reducing the rate of spread and increasing responsiveness to chemoradiation.

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“…Numerous studies have demonstrated a direct link between TGFβ/NF-κB signaling and MMP overexpression in various cancers [35]–[38]. MMPs, a family of zinc-dependent endopeptidases that catalyze the disintegration of the ECM and basement membrane play a pivotal role in tumor invasion and angiogenesis [39].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Signature of DMBA-Induced Hamster Buccal Pouch Carcinomas: Modulation by Chlorophyllin and Ellagic Acid

et al. 2012

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Chlorophyllin (CHL), a water-soluble, semi-synthetic derivative of chlorophyll and ellagic acid (EA), a naturally occurring polyphenolic compound in berries, grapes, and nuts have been reported to exert anticancer effects in various human cancer cell lines and in animal tumour models. The present study was undertaken to examine the mechanism underlying chemoprevention and changes in gene expression pattern induced by dietary supplementation of chlorophyllin and ellagic acid in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model by whole genome profiling using pangenomic microarrays. In hamsters painted with DMBA, the expression of 1,700 genes was found to be altered significantly relative to control. Dietary supplementation of chlorophyllin and ellagic acid modulated the expression profiles of 104 and 37 genes respectively. Microarray analysis also revealed changes in the expression of TGFβ receptors, NF-κB, cyclin D1, and matrix metalloproteinases (MMPs) that may play a crucial role in the transformation of the normal buccal pouch to a malignant phenotype. This gene expression signature was altered on treatment with chlorophyllin and ellagic acid. Our study has also revealed patterns of gene expression signature specific for chlorophyllin and ellagic acid exposure. Thus dietary chlorophyllin and ellagic acid that can reverse gene expression signature associated with carcinogenesis are novel candidates for cancer prevention and therapy.

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Prognostic value of transforming growth factor beta 1 [TGF-β1] and matrix metalloproteinase 9 [MMP-9] in oral squamous cell carcinoma

Abstract: Unlike TGF-β1, MMP-9 might be useful for prognosis determination.

Cited by 36 publications

References 25 publications

Role of Cyclooxygenase-2, Ezrin and Matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma

Role of Cyclooxygenase-2, Ezrin and Matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma

Mechanisms of Invasion in Head and Neck Cancer

Gene Expression Signature of DMBA-Induced Hamster Buccal Pouch Carcinomas: Modulation by Chlorophyllin and Ellagic Acid

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