Role of Cyclooxygenase-2, Ezrin and Matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma

El‐Khalawany, Mohamed; Abou-Bakr, Amany A

doi:10.4103/0973-1482.126456

Cited by 16 publications

(21 citation statements)

References 21 publications

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“…Although various risk factors for increased incidence of recurrent BCC exist [33], none of them should be considered individually. Clinical risk factors for BCC recurrence include male sex, lesion topography (centrofacial region involving the inner canthus, nostrils, and periauricular area), tumor size (recurrence rate increases by 7% for each millimeter of increase in tumor diameter), photosensitivity, and over 60 years of age at first presentation [34, 35].…”

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

“…A proteomic approach of potential predictive markers for BCC recurrence employed the study of cyclooxygenase-2, ezrin, and matrix metalloproteinase-9 [33]. …”

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

“…Moreover, a connection between COX-2 overexpression and increased levels of vascular endothelial growth factor-A (VEGF-A), CD31 positive vessels, and regulators of apoptosis Mcl-1 and Bcl2 has been implied by previous studies [41]. El-Khalawany and Abou-Bakr found that 90.9% of recurrent BCCs (rBCC) expressed COX-2 compared to only 59.1% of nonrecurrent BCCs (nrBCC) [33]. Conversly, it was shown that COX-2 inhibition can mitigate tumor growth, decrease the expression cell proliferation markers, and promote cancerous cell apoptosis [39, 40].…”

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

“…Higher frequencies for ezrin immunopositivity have been observed in rBCCs than in nrBCCs [33]. While Bagheri and collaborators found ezrin expression in 93% of the tested BCCs, no significant difference regarding ezrin expression was observed between different BCC subtypes.…”

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

“…Dumas et al considered the reduced expression of collagen IV accompanied by the increased expression of MMP-9 and MMP-2 could explain the increased aggressive behavior of SCC over BCC [52]. One study [33] did not find any statistically significant difference between MMP-9 expressions in recurrent versus nonrecurrent BCCs.…”

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

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Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

et al. 2016

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Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predisposed individuals, this being reflected by the anatomical distribution of lesions mainly on sun-exposed skin areas. Early diagnosis and prompt management are of crucial importance in order to prevent local tissue destruction and subsequent disfigurement. Although various noninvasive or minimal invasive techniques have demonstrated their utility in increasing diagnostic accuracy of BCC and progress has been made in its treatment options, recurrent, aggressive, and metastatic variants of BCC still pose significant challenge for the healthcare system. Analysis of gene expression and proteomic profiling of tumor cells and of tumoral microenvironment in various tissues strongly suggests that certain molecules involved in skin cancer pathogenic pathways might represent novel predictive and prognostic biomarkers in BCC.

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Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

“…A proteomic approach of potential predictive markers for BCC recurrence employed the study of cyclooxygenase-2, ezrin, and matrix metalloproteinase-9 [33]. …”

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

Section: Recurrent and Subsequent Basal Cell Carcinomasmentioning

confidence: 99%

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Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

et al. 2016

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Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma

et al. 2016

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The aim of this study was to compare the expressions of mRNA for metalloproteinases (MMP-2 and MMP-9) and type IV collagen in two different histological types of basal-cell carcinoma (BCCs; nodular and infiltrative) and in normal tissues from the tumor interface. The study included biopsy specimens of the skin involved with BCC and normal skin adjacent the lesion. The expressions of mRNA for MMP-2, MMP-9 and type IV collagen were determined by means of RT-PCR (Reverse transcription polymerase chain reaction). The level of type IV collagen mRNA in nodular and infiltrative BCCs turned out to be significantly lower, and the expressions of MMP-2 and MMP-9 mRNA significantly higher than in normal tissues adjacent to these tumors. The expression of mRNA for MMP-9 but not for MMP-2 was significantly higher in infiltrative BCCs than in the nodular BCCs. In turn, normal tissues adjacent to nodular BCCs showed significantly higher levels of mRNA for MMP-2 and significantly lower levels of type IV collagen mRNA than the normal tissues from the interface of infiltrative BCCs. The findings suggest that MMP-2 and MMP-9 could be used as prognostic factors of BCCs.

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Evidence-based update on rosacea comorbidities and their common physiologic pathways

Holmes

Spoendlin

Chien³

et al. 2018

Journal of the American Academy of Dermatology

105

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Role of Cyclooxygenase-2, Ezrin and Matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma

Abstract: Biologic markers may have a promising role in assessment of BCC prognosis and early detection of recurrence. High COX-2 expression could be considered as a risk factor of BCC recurrence that can be added to other clinical and histologic factors.

Cited by 16 publications

References 21 publications

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma

Evidence-based update on rosacea comorbidities and their common physiologic pathways

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