Prognostic value of transthoracic coronary flow reserve in medically treated patients with proximal left anterior descending artery stenosis of intermediate severity

Abstract

In patients with proximal LAD stenosis of intermediate severity and T-CFR>2, deferral of revascularization is associated with low event rate.

Significance of relative coronary flow reserve in patient with microvascular dysfunction to differentiate significant coronary artery stenosis

“…CFR-TTE together with 2-dimensional echocardiography provide better sensitivity up to 93% and still good specificity 80.6% for detection of diseased LAD 5 . Also favorably results were recently published, showing that CFR-TTE is a helpful noninvasive tool in the decision making whether to proceed PCI or to continue treatment with medical therapy in patients with intermediate coronary artery stenosis 1,6,7 . On the other hand, in many clinical conditions such as hypertrophic cardiomyopathy (HCM), aortic stenosis, dilatative cardiomyopathy, diabetes, syndrome X and presence of myocardial scar, there is impairment of microcirculation which is reflected with decreased CFR even though coronary arteries are without stenosis 1,[6][7][8][9] .…”

Prognostic value of non-invasive assessment of left anterior descending coronary artery blood flow during exercise test in patients with previous myocardial infarction

“…В связи с чем сравнение результатов с други-ми исследованиями ограничено сопоставлением с работа-ми по измерению КРпмжа при введении вазодилататоров. Предшествующие работы доказали возможность высокой прогностической точности неинвазивно измеренного КРпмжа при проведении фармакологических тестов [9,18,[20][21][22][23] у пациентов с предполагаемой или диагности-рованной ИБС. КРпмжа<2 был ассоциирован с неблаго-приятными исходами у группы пациентов с положитель-ным или отрицательным результатом стресс-ЭхоКГ, па-раметром, дополняющим анализ нарушений сократимо-сти ЛЖ [9].…”

Coronary flow velocity reserve predicts survival in non-diabetic patients

“…The prognostic role of echocardiography-derived CFR is widely examined in patients with suspected or known CAD [2][3][4][7][8][9][16][17][18][19][20][21][22][23][24][25]. CFR has a prognostic significance on cardiovascular outcome not only in patients with significant CAD [16], but also in subjects with intermediate (50 to 75%) LAD stenosis [17,18] or angiographically normal or near-normal coronary arteries [4,8,19].…”

“…CFR has a prognostic significance on cardiovascular outcome not only in patients with significant CAD [16], but also in subjects with intermediate (50 to 75%) LAD stenosis [17,18] or angiographically normal or near-normal coronary arteries [4,8,19]. Sicari et al found that ongoing antiischemic therapy at the time of testing does not modulate the prognostic value of CFR [20].…”