Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer

Benzoni, Enrico

doi:10.1136/jcp.2005.031609

Cited by 28 publications

(22 citation statements)

References 42 publications

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“…However, the pathologic evaluation of rectal cancer after irradiation is more complicated than that of a primary tumor because a considerable proportion of patients achieves tumor regression and histologic downstaging after radiotherapy; thus, the pathologic staging system (ypTNM stage) has a different clinical meaning than for untreated cancers [7,8]. Nevertheless, few methods are available to assess the prognosis of postirradiation rectal cancer accurately, especially in tumors that are insensitive to radiation, in which determination of prognosis is critically important because these patients tend to have poor oncological outcomes [9,10].…”

Section: Introductionmentioning

confidence: 98%

Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy

Xue

et al. 2012

Human Pathology

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Section: Introductionmentioning

confidence: 98%

Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy

Xue

et al. 2012

Human Pathology

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“…Systemic and local inflammatory responses may play an important role in tumor regression in rectal cancer following radiotherapy. Various studies have revealed that radiation-induced local immune reactions contribute to tumor regression by inflammatory infiltration [7][8][9]. Subpopulations of tumorinfiltrating lymphocytes (TILs) are considered to comprise cytotoxic T cells, regulatory T cells, and memory T cells [10].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy

Wang

Zhai

et al. 2015

Int J Colorectal Dis

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“…Patients with pCR had a significantly greater probability of DFS and OS than non-responders. Rectal cancer-related death was 11.02% [14]: one patient (5.26%) with pCR, 9.47% [7] in the downstaged group and 17.64% [6] of nonresponders. …”

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confidence: 99%

Pathologic response to neoadjuvant treatment in locally advanced rectal cancer and impact on outcome

Jalilian¹,

Davis²,

Mohebbi³

et al. 2016

J. Gastrointest. Oncol.

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.Background: Downstaging and pathologic complete response (pCR) after chemoradiotherapy (CRT) may improve progression-free survival and overall survival (OS) after curative therapy of locally advanced adenocarcinoma of rectum. The purpose of this study is to evaluate the pathologic response subsequent to neoadjuvant chemoradiation in locally advanced rectal adenocarcinoma and any impact of response on oncological outcome [disease-free survival (DFS), OS].Methods: A total of 127 patients with histologically-proven rectal adenocarcinoma, locally advanced, were treated with preoperative radiotherapy and concurrent 5-fluorouracil (5 FU), and followed by curative surgery. Pathologic response to neoadjuvant treatment was evaluated by comparing pathologic TN (tumour and nodal) staging (yp) with pre-treatment clinical staging. DFS and OS were compared in patients with:pCR, partial pathologic response and no response to neoadjuvant therapy. showed distant metastasis, none showed local recurrence. In the downstaged group, nine developed distant failure and two had local recurrence (14.86%). Distant failure was seen in 26.47% [9] of those with no response to neoadjuvant treatment. DFS and OS rates for all groups were 82.67% and 88.97% respectively. ResultsPatients with pCR showed 89.47% DFS and 94.7% OS. In partial responders, DFS was 85.1% and OS was 90.5%. In non-responders, DFS and OS were 73.5% and 82.3% respectively. Patients with pCR had a significantly greater probability of DFS and OS than non-responders. Rectal cancer-related death was 11.02% [14]: one patient (5.26%) with pCR, 9.47% [7] in the downstaged group and 17.64% [6] of nonresponders. Conclusions:The majority of patients showed some response to neoadjuvant treatment. Findings of this study indicate tumour response to neoadjuvant CRT improves the long-term outcome, with a better result in patients with pCR.

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Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer

Cited by 28 publications

References 42 publications

Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy

Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy

Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy

Pathologic response to neoadjuvant treatment in locally advanced rectal cancer and impact on outcome

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