Prognostic value of vascular endothelial growth factor expression in gastric carcinoma

Maeda, Kiyoshi; Chung, Yong‐Suk; Ogawa, Yoshinari; Kang, Soon-Myoung; Ogawa, Masafumi; Sawada, Tetsuji; Sowa, Michio

doi:10.1002/(sici)1097-0142(19960301)77:5<858::aid-cncr8>3.0.co;2-a

Cited by 563 publications

(343 citation statements)

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“…Moreover, tissue VEGF concentration measured by ELISA was also an independent prognostic factor for patients with soft tissue sarcomas. Similar results have been reported in studies on several cancers including human colon cancer (Takahashi et al, 1995), brain tumour (Takano et al, 1996), and gastric cancer (Maeda et al, 1996).…”

Section: Discussionsupporting

confidence: 88%

“…It is now thought that expression of the tumour cell derived angiogenic factors is specific to each tumour and dependent on the process of tumour growth and spreading. Several studies have noted that the level of expression of VEGF, which is a strong angiogenic factor, correlates with neovascularity and with tumour progression in human colon cancer (Takahashi et al, 1995), human brain tumour (Takano et al, 1996), human breast cancer (Maeda et al, 1996), and several experimental tumour models (Miller et al, 1994;Zhang et al, 1995;Claffey et al, 1996). VEGF secreted from tumours may contribute to tumour growth, invasion and metastasis not only via an autocrine pathway to tumour cells, but via a paracrine pathway to surrounding microvessels (Takahashi et al, 1995).…”

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confidence: 99%

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Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas

et al. 2001

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Previous studies have shown that the prognosis of patients who have tumours with high microvessel density (MVD) is worse than that of patients who have a lower density in a variety of cancers. In this study, we investigated the clinical relevance of neovascularity assessed by MVD and the concentration of vascular endothelial growth factor (VEGF) in the tumour tissue of patients with soft tissue sarcoma in comparison with major clinicohistologic parameters by univariate and multivariate analysis. In 115 patients with soft tissue sarcoma, MVD was measured by counting vessels stained with factor VIII antibody. The concentration of VEGF in the tumour tissue was determined by enzyme-linked immunosorbent assay. These parameters were then compared with disease outcome. The concentration of VEGF in the tumour tissue, but not MVD, was found to be correlated with disease outcome in patients with soft tissue, sarcoma. VEGF concentration in the tumour tissue showed a relationship with the clinical stage and histologic grade of the tumour. There was no significant difference in the levels of tissue VEGF concentration and MVD among soft tissue sarcomas classified according to histologic type. The level of tissue VEGF concentration in patients who had subsequent local recurrence and metastasis were significantly higher than the respective values in patients who did not have such disease outcome. No significant correlation existed between MVD and the concentration of VEGF in the tumour tissue. Univariate analysis showed that a high tissue VEGF concentration was associated with poor overall survival of the patient and a greater probability that local recurrence and metastasis had occurred. Multivariate analysis revealed that the tissue concentration of VEGF is an independent prognostic factor for the disease outcome of patients with soft tissue sarcoma. VEGF concentration in the tumour tissue, but not MVD, is an additional prognostic parameter for disease outcome in patients with soft tissue sarcoma, regardless of histologic type. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Section: Discussionsupporting

confidence: 88%

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confidence: 99%

Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas

et al. 2001

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“…It is mitogenic and angiogenic for endothelial cells, and it can also increase vascular permeability. A number of tumour cells in humans have been seen to express higher levels of VEGF mRNA compared to normal tissue (Brown et al, 1993;Plate et al, 1993;Abu-Jawdeh et al, 1996;Yoshiji et al, 1996), suggesting an association of VEGF with a malignant phenotype; furthermore, an elevated VEGF expression has also been correlated to a worse prognosis in cancers such as gastric (Maeda et al, 1996;Takahashi et al, 1996), colonic (Takahashi et al, 1995) and lung carcinomas (Mattern et al, 1995;Ohta et al, 1996;Fontanini et al, 1997bFontanini et al, , 1999.…”

Section: Discussionmentioning

confidence: 99%

A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma

et al. 2002

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It has been widely demonstrated that neo-angiogenesis and its mediators (i.e. vascular endothelial growth factor), represent useful indicators of poor prognosis in non small cell lung carcinoma. In order to verify whether neovascularization and vascular endothelial growth factor may be considered useful markers of clinical outcome also in the small cell lung cancer subgroup, we retrospectively investigated a series of 75 patients with small cell lung carcinoma treated by surgery between 1980 and 1990. Immunohistochemically-detected microvessels and vascular endothelial growth factor expressing cells were significantly associated with poor prognosis, as well as with nodal status and pathological stage. In fact, patients whose tumours had vascular count and vascular endothelial growth factor expression higher than median value of the entire series (59 vessels per 0.74 mm 2 and 50% of positive cells, respectively), showed a shorter overall and disease-free survival ( P =0.001, P =0.001; P =0.008, P =0.03). Moreover, the presence of hilar and/or mediastinal nodal metastasis and advanced stage significantly affected overall and disease-free interval ( P =0.00009, P =0.00001; P =0.0001, P =0.00001). At multivariate analysis, only vascular endothelial growth factor expression retained its influence on overall survival ( P =0.001), suggesting that angiogenic phenomenon may have an important role in the clinical behaviour of this lung cancer subgroup. British Journal of Cancer (2002) 86 , 558–563. DOI: 10.1038/sj/bjc/6600130 www.bjcancer.com © 2002 Cancer Research UK

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“…11,12 VEGF is produced in a great variety of cells and is expressed in tumors of many tissues, including lung, breast, stomach, colon, thyroid, kidney, bladder, ovary, and pituitary. [13][14][15][16][17][18][19][20][21] VEGF also has been identified in human craniopharyngiomas, and it has been suggested that cystic foci in these tumors are related to the degree of VEGF expression. 22 To assess directly whether VEGF in craniopharyngiomas is associated with angiogenesis and tumor behavior, we compared the expression pattern of VEGF with both microvessel density (MVD) and clinicopathologic features in 32 adult patients with craniopharyngiomas of both histologic types.…”

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Angiogenesis in patients with craniopharyngiomas

Vidal

Kovács

Lloyd

et al. 2002

Cancer

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The functional single‐coordinate phosphine oxide ligands (4‐diphenylaminophenyl)diphenylphosphine oxide (TAPO), (4‐naphthalen‐1‐yl‐phenylaminophenyl)diphenylphosphine oxide (NaDAPO), and 9‐[4‐(diphenylphosphinoyl)phenyl]‐9H‐carbazole (CPPO), as the direct combinations of hole‐transporting moieties, and electron‐transporting triphenylphosphine oxide (TPPO) were designed and synthesized (amines or carbazole), together with their EuIII complexes [Eu(tapo)2(tta)3] (1), [Eu(nadapo)2(tta)3] (2), and [Eu(cppo)2(tta)3] (3; TTA: 2‐thenoyltrifluoroacetonate). The investigation indicated that by taking advantage of the modification inertia of the phosphine oxide ligands, the direct introduction of the hole‐transport groups as chromophore made TAPO, NaDAPO, and CPPO obtain the most compact structure and mezzo S1 and T1 energy levels, which improved the intramolecular energy transfer in their EuIII complexes. The amorphous phase of 1–3 proved the weak intermolecular interaction, which resulted in extraordinarily low self‐quenching of the complexes. The excellent double‐carrier transport ability of the ligands was studied with Gaussian calculations, and the bipolar structure of TAPO and CPPO was proved. The great improvement of the double‐carrier transport ability of 1–3 was shown by cyclic voltammetry. Their HOMO and LUMO energy levels of around 5.3 and 3.0 eV, respectively, are the best results for EuIII complexes reported so far. A single‐layer organic light‐emitting diode of 2 had the impressive brightness of 59 cd m−2 which, to the best of our knowledge, is the highest reported so far. Both of the four‐layer devices based on pure 1 and 2 had a maximum brightness of more than 1000 cd m−2, turn‐on voltages lower than 5 V, maximum external quantum yields of more than 3 % and excellent spectral stability.

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Prognostic value of vascular endothelial growth factor expression in gastric carcinoma

Abstract: The expression of VEGF may be a good prognostic indicator for patients with gastric carcinoma and may also be useful as a predictor of the mode of recurrence in patients with gastric carcinoma.

Cited by 563 publications

References 15 publications

Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas

Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas

A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma

Angiogenesis in patients with craniopharyngiomas

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