Prognostication in the era of a new stressor for myocardial perfusion imaging

Comparison of the prognostic value of regadenoson and adenosine myocardial perfusion imaging

“…8 Moreover, Hage and colleagues have shown progressively increasing event rates with larger quantitative perfusion defect size using regadenoson SPECT MPI. 25,26 Our results add to this body of knowledge by showing that SSS derived from either agent is significant in predicting events and provides incremental prognostic information above and beyond basic clinical variables. Furthermore, we have demonstrated no difference in SSS predicted probabilities for occurrence of events between the two stress agents.…”

Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging

“…This can be attained by several well established nuclear imaging techniques. The noninvasive nuclear medicine techniques such as stress echocardiography, coronary computed tomography, angiography, positron emission tomography or myocardial perfusion imaging (MPI) with single photon emission computed tomography are highly used . MPI has the advance in assessing the physiological consequences of coronary stenosis; besides, it could be performed with exercise and pharmacological stress …”

Development of kit formulations for 99mTcN‐MPO: a cationic radiotracer for myocardial perfusion imaging

“…MPI with radiotracers is a well‐established noninvasive method of assessing the coronary blood flow. MPI is capable of identifying regional abnormalities in coronary artery and determining their physiological relevance to myocardial function and viability . Despite the recent development in echocardiography and coronary computed tomography angiography, MPI with SPECT radiotracers remains the only reliable imaging modality for assessment of physiological consequence of coronary stenosis or myocardial infarction and can be combined exercise with pharmacological stress, particularly with the development of the dedicated ultrafast cardiac camera …”

“…The combination of its nuclear properties and diverse coordination chemistry makes 99m Tc the ideal isotope to develop new perfusion imaging agents. Since the 1980s, intensive research efforts have been directed toward using cationic and neutral 99m Tc complexes (Figure ) as radiotracers for MPI . As a result of these extensive efforts, 99m Tc‐sestamibi and 99m Tc‐tetrofosmin (Figure ) have been approved as commercial radiotracers for SPECT MPI.…”