Program for lung cancer screening and tobacco cessation: Study protocol of a sequential, multiple assignment, randomized trial

Fu, Steven S.; Rothman, Alexander J.; Vock, David M.; Lindgren, Bruce R.; Almirall, Daniel; Begnaud, Abbie; Melzer, Anne C.; Schertz, Kelsey; Glaeser, Susan; Hammett, Patrick J.; Joseph, Anne M.

doi:10.1016/j.cct.2017.07.002

Cited by 32 publications

(30 citation statements)

References 71 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[30][31][32][33] The National Cancer Institute's Smoking Cessation at Lung Examination initiative includes eight trials designed to provide a robust evidence base of feasible, scalable approaches to providing smoking cessation, including combinations of pharmacotherapy, in-person counseling, and telephone counseling. 11,[13][14][15][16] The National Cancer Institute-Lung Population-based Research to Optimize the Screening Process initiative is now also evaluating the implementation of screening-based cessation programs across diverse health systems. 35 However, the results of these trials and studies will not be available for several years.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, little is known about the efficacy of cessation interventions in the screening setting. There are clinical trials underway to fill this gap, 11,[13][14][15][16] but results are not expected for several years. 17 Furthermore, little is known about the potential synergistic effects of joint screening and smoking cessation programs on population lung cancer and tobacco-related morbidity and mortality rates.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Impact of Cessation Interventions at the Point of Lung Cancer Screening on Lung Cancer and Overall Mortality in the United States

Cao

Jeon

Levy

et al. 2020

Journal of Thoracic Oncology

View full text Add to dashboard Cite

Introduction: Annual lung cancer screening with low-dose computed tomography is recommended for adults aged 55 to 80 years with a greater than or equal to 30 pack-year smoking history who currently smoke or quit within the past 15 years. The 50% who are current smokers should be offered cessation interventions, but information about the impact of adding cessation to screening is limited. Methods:We used an established lung cancer simulation model to compare the effects on mortality of a hypothetical one-time cessation intervention and annual screening versus annual screening only among screen-eligible individuals born in 1950 or 1960. Model inputs were derived from national data and included smoking history, probability of quitting with and without intervention, lung cancer risk and treatment effectiveness, and competing tobacco-related mortality. We tested the sensitivity of results under different assumptions about screening use and cessation efficacy.Results: Smoking cessation reduces lung cancer mortality and delays overall deaths versus screening only across all assumptions. For example, if screening was used by 30% of screen-eligible individuals born in 1950, adding an intervention with a 10% quit probability reduces lung cancer deaths by 14% and increases life years gained by 81% compared with screening alone. The magnitude of cessation benefits varied under screening uptake rates, cessation effectiveness, and birth cohort.Conclusions: Smoking cessation interventions have the potential to greatly enhance the impact of lung cancer screening programs. Evaluation of specific interventions, including costs and feasibility of implementation and dissemination, is needed to determine the best possible strategies and realize the full promise of lung cancer screening.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential Impact of Cessation Interventions at the Point of Lung Cancer Screening on Lung Cancer and Overall Mortality in the United States

Cao

Jeon

Levy

et al. 2020

Journal of Thoracic Oncology

View full text Add to dashboard Cite

show abstract

“…Eligible participants 1) identified as Latino, 2) were ≥18 years of age, 3) smoked a minimum of 5 days in the past week,13 4) had an active mobile phone, and 5) were ready to quit smoking in the next 30 days. Individuals were excluded if 1) they were pregnant, breastfeeding or planning to do so in the following year, or 2) they were planning to move from the study area within the next 6 months.…”

Section: Methodsmentioning

confidence: 99%

<p>“Every day I think about your messages”: assessing text messaging engagement among Latino smokers in a mobile cessation program</p>

Cartujano-Barrera¹,

Arana-Chicas²,

Ramírez³

et al. 2019

PPA

View full text Add to dashboard Cite

Introduction Mobile health interventions are a promising mode to address tobacco-related disparities among Latinos, the largest minority group and the highest users of text messaging technology. The purpose of this pilot study was to assess engagement in a smoking cessation intervention delivered via text message (Kick Buts) among Latino smokers. Methods We relied on a community-based recruitment strategy to enroll 20 Latino smokers in Kick Buts. Outcome measures included biochemically verified abstinence at 12 weeks, participant text messaging interactivity with the program, and satisfaction. Results Participants’ mean age was 40.7 years old (SD=14.6). Most of the participants were male (70%), did not have health insurance (75%), and reported low nicotine-dependence (60%). The majority of participants (75%) sent at least one text message to the program. On average, participants who interacted with the program sent 31.8 (SD=39.7) text messages. Eight themes were identified in participants’ messages (eg, well-being, self-efficacy, strategies to quit, extra-treatment social support, etc). At 12 weeks, 30% of the participants were biochemically verified as abstinent. Conclusion A smoking cessation text message intervention generated high engagement among Latinos and resulted in noteworthy cessation rates. Future studies should assess the relationship of text messaging interactions with psychological effects (eg, intra-treatment social support, therapeutic alliance, and perceived autonomy support).

show abstract

“…96 Although data collection is ongoing, several of these trials have recently published their clinical protocols and study designs. 97,98 In summary, despite the strong endorsement that high-quality lung cancer screening should include integration of evidence-based tobacco treatment, the optimal approach for delivering feasible, cost-effective, and sustainable cessation interventions in the context of LDCT screening remains largely unknown. Patient, provider, and systems levels barriers exist and await further needed research on implementation processes and outcome.…”

Section: Screening and Smoking Cessationmentioning

confidence: 99%

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Balata

Fong

Hendriks

et al. 2019

Journal of Thoracic Oncology

View full text Add to dashboard Cite

Lung cancer remains the leading cause of cancer-related mortality worldwide. Tobacco consumption remains the most important risk factor. Although the prevalence of smoking has decreased overall, it continues to be a significant burden for global health. It is estimated that there are still nearly 1 billion cigarette smokers worldwide. Prevention strategies have largely focused on tobacco control and prevention. However, we have witnessed a dramatic increase in the use of e-cigarettes and other vaping products. Primary chemoprevention has historically not been a successful strategy for lung cancer; however, focused approaches in specific groups of patients at high risk for development of lung cancer are underway. The majority of cases with NSCLC are diagnosed with locally advanced or metastatic disease, where the overall prognosis remains very poor. Early-stage NSCLC on the other hand has a much better prognosis and can usually be treated radically with either surgical resection or radical radiotherapy, with relatively favorable long-term outcomes. In addition to image-based screening, other methods such as breath-based and biofluidbased approaches are now being investigated for early detection of NSCLC. This review will focus on recent advancements in the field of prevention, screening, and early detection of NSCLC.

show abstract

Program for lung cancer screening and tobacco cessation: Study protocol of a sequential, multiple assignment, randomized trial

Cited by 32 publications

References 71 publications

Potential Impact of Cessation Interventions at the Point of Lung Cancer Screening on Lung Cancer and Overall Mortality in the United States

Potential Impact of Cessation Interventions at the Point of Lung Cancer Screening on Lung Cancer and Overall Mortality in the United States

<p>“Every day I think about your messages”: assessing text messaging engagement among Latino smokers in a mobile cessation program</p>

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Contact Info

Product

Resources

About