Programmable Construction of Peptide‐Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics

Li, Lili; Qiao, Zeng‐Ying; Wang, Lei; Wang, Hao

doi:10.1002/adma.201804971

Cited by 93 publications

(53 citation statements)

References 76 publications

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“…As one of the most essential organelles, the implementation of non-drug-loaded peptide nanoassemblies for mitochondriatargeted therapy has attracted increasing attention (Jeena et al, 2017;Du et al, 2018;Li et al, 2018;Liu et al, 2018;. Given that the elimination of cancer cells was conducted by the nanoassemblies themselves without using drugs, it undoubtedly avoids MDR.…”

Section: Mitochondria-targeted Cancer Therapymentioning

confidence: 99%

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

et al. 2020

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Binding small molecules through non-covalent molecular forces affords supramolecules, such as hydrogen bonds, with electrostatic, π-π interactions, van der Waals forces, and hydrophobic effects. Due to their good biocompatibility, low immunogenicity, and biodegradability, supramolecules have been intensely studied as multifunctional drug delivery platforms in targeted cancer therapy. In consideration of the defective therapeutic efficacy induced by simply transporting the therapeutic agents into tumor tissues or cancer cells instead of subcellular organelles, research is progressing toward the development of subcellular targeted cancer therapy (STCT) strategies. STCT is one of the most recent developments in the field of cancer nanomedicine. It is defined as the specific transportation of therapeutic agents to the target organelles for cancer treatment, which makes therapeutic agents accumulate in the target organelles at higher concentrations than other subcellular compartments. Compared with tumor-targeted and cancer-cell-targeted therapies, STCT exhibits dramatically improved specificity and precision, diminished adverse effects, and enhanced capacity to reverse multidrug resistance (MDR). Over the past few decades, peptides have played increasingly essential roles in multi-types of tumor-targeted drug delivery systems. Moreover, peptide-mediated STCT is becoming an emerging approach for precision cancer therapy and has been used in various cancer treatments, such as photothermal therapy (PTT), photodynamic therapy (PDT), chemotherapy, gene therapy, and non-drug-loaded nanoassemblies. In this review, we will focus on recent innovations in the variety of peptides used in designing peptide-decorated supramolecules for cell-membrane-, mitochondria-, and nucleus-localized STCT.

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Section: Mitochondria-targeted Cancer Therapymentioning

confidence: 99%

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

et al. 2020

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“…Peptide sequences containing stimuli-responsive groups can be incorporated on demand, which not only plays a significant role in drug release but also promotes the strategy formation of intracellular ( in vivo ) self-assembly. Intracellular self-assembly based on biocompatible condensation reaction 95-97, endogenous stimuli reconstruction upon the control of either pH, disulfide reduction or enzymatic cleavage 17, 98 has shown great potential in improving targeting cellular uptake of the drug molecules in chemotherapy.…”

Section: Peptide-drug Assembly Strategiesmentioning

confidence: 99%

“…In nature, the self-assembly or organization of biomolecules into intricate and functional units in living organisms provides a rationale to construct supramolecular structures that harness the power of multiple noncovalent forces, including electrostatic forces, van der Waals forces, π interactions, hydrophobic interactions and coordination interactions 12-14. These attractive forces are typically much weaker than covalent bonds, and these interactions occur in a dynamic and reversible manner, thus allowing self-assemblies to adapt to physiological conditions and maximize their biological functions 15-17. In particular, peptides, as the fundamental components of proteins, show superior characteristics to those of existing assembly motifs as building blocks for the fabrication of nanotheranostics.…”

Section: Introductionmentioning

confidence: 99%

Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics

Zou

Xing

et al. 2019

Theranostics

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Advances in supramolecular self-assembly have promoted the development of theranostics, the combination of both therapeutic and diagnostic functions in a single nanoplatform, which is closely associated with antitumor applications and has shown promising potential in personalized medicine. Peptide-modulated self-assembly serves as a versatile strategy for tumor supramolecular nanotheranostics possessing controllability, programmability, functionality and biosafety, thus promoting the translation of nanotheranostics from bench to bedside. In this review, we will focus on the self-assembly of peptide-photosensitizers and peptide-drugs as well as multicomponent cooperative self-assembly for the fabrication of nanotheranostics that integrate diagnosis and therapeutics for antitumor applications. Emphasis will be placed on building block design, interaction strategies and the potential relationships between their structures and properties, aiming to increase understanding of the critical role of peptide-modulated self-assembly in advancing antitumor supramolecular nanotheranostics.

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“…extensive attention in enhancing the intracellular drug accumulation via morphological transformation from small-sized particles to large aggregates in lesions. [16,17] However, stimuli responsive morphological transformation often relies on the elaborate design and laborious synthesis of PDCs bearing stimuli-responsive functional groups, which significantly restricts their clinical translation in chemotherapy. In addition, most morphology-transformable PDCs depend on physiological stimuli including pH, [18] reducing agents, [19] and enzymes, [20] which are not specific enough to distinguish the disease tissues from the normal ones.…”

Section: Introductionmentioning

confidence: 99%

Polyamine‐Responsive Morphological Transformation of a Supramolecular Peptide for Specific Drug Accumulation and Retention in Cancer Cells

Sun

Wang

Yang

et al. 2021

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The precise accumulation and extended retention of nanomedicines in the tumor tissue has been highly desired for cancer therapy. Here a novel supramolecular‐peptide derived nanodrug (SPN) that can be transformed to microfibers in response to intracellular polyamine in cancer cells for significantly enhanced tumor specific accumulation and retention is developed. The supramolecular‐peptide is constructed via the non‐covalent interactions between cucurbit[7]uril (CB[7]) and Phe on Phe‐Phe‐Val‐Leu‐Lys‐camptothecin conjugates (FFVLK‐CPT, PC). The resultant amphiphilic supramolecular complex subsequently self‐assembles into nanoparticles with a hydrodynamic diameter of 164.2 ± 3.7 nm. Upon internalization into spermine‐overexpressed cancer cells, the CB[7]‐Phe host–guest pairs can be competitively dissociated by spermine and can release free PC, which immediately form β‐sheet structures and subsequently reorganize into microfibers, leading to dramatically improved accumulation, retention, and sustained release of CPT in tumor cells for highly effective cancer therapy. Accordingly, this SPN exhibit rather low toxicity against non‐cancerous cells due to the morphological stability and fast exocytosis of the nanodrugs in those cells without abundant spermine. This study reports the first supramolecular peptide capable of polyamine‐responsive “nanoparticle‐to‐microfiber” transformation for specific tumor therapy with minimal side effects. This work also offers novel insights to the design and development of stimuli‐responsive nanomaterials as precision medicine.

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Programmable Construction of Peptide‐Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics

Cited by 93 publications

References 76 publications

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

Peptide-Decorated Supramolecules for Subcellular Targeted Cancer Therapy: Recent Advances

Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics

Polyamine‐Responsive Morphological Transformation of a Supramolecular Peptide for Specific Drug Accumulation and Retention in Cancer Cells

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