Programmable Medicine: Autonomous, Ingestible, Deployable Hydrogel Patch and Plug for Stomach Ulcer Therapy

d'Argentre, Alexis du Plessis; Perry, Samuel W.; Iwata, Yoshitaka; Iwasaki, Haruna; Iwase, Eiji; Fabozzo, Assunta; Will, Iain; Rus, Daniela; Damian, Dana D.; Miyashita, Shuhei

doi:10.1109/icra.2018.8460615

Cited by 23 publications

(25 citation statements)

References 30 publications

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“…[30,31] In closing, Hoberman flight rings are realized using DNA origami, which forms a trefoil knot. The deployable and auxetic nanostructures may serve as a versatile platform for topological studies and open new opportunities for bioengineering and biosensors such as high-precision drug delivery [32] and molecular targeting and swallow. [33]…”

Section: S X Y = ⋅mentioning

confidence: 99%

Topological Assembly of a Deployable Hoberman Flight Ring from DNA

Chen

Choi

2021

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Deployable geometries are 2D or 3D finite structures that preserve their global shapes during expansion and contraction. [1] The structural transformation shows auxetic behaviors, which may be characterized by a negative Poisson's ratio (ν). Such topological behaviors emerge from their unique, intricate geometrical designs. In a Jitterbug transformer, for example, eight rigid equilateral triangles are linked at vertices, and the triangles can rotate around the linkages. [2] This allows deployable reconfigurations between octahedron (one of five Platonic solids) and cuboctahedron (one of thirteen Archimedean solids). By varying the shape and length of elements (regular polygons) in the transformer, multiple variants such as other deployable Platonic and Archimedean solids have been studied mathematically. [3] Another example is the Hoberman sphere, a commercially available, popular toy for kids and a possible choice for sculptures. The Hoberman sphere is also formed by rigid edges with flexible linkages, [4] and can shrink and expand by scissor-like actions at the joints while maintaining the overall spherical shape. In theory, it can be constructed regardless of materials and lengthscale. There is a 6-m-diameter Hoberman sphere from aluminum in the AHHAA Science Center in Tartu, Estonia, while the commercial toys made of plastics are typically ≈10 cm in length. [5] In nature, the shell of cowpea Deployable geometries are finite auxetic structures that preserve their overall shapes during expansion and contraction. The topological behaviors emerge from intricately arranged elements and their connections. Despite the considerable utility of such configurations in nature and in engineering, deployable nanostructures have never been demonstrated. Here a deployable flight ring, a simplified planar structure of Hoberman sphere is shown, using DNA origami. The DNA flight ring consists of topologically assembled six triangles in two layers that can slide against each other, thereby switching between two distinct (open and closed) states. The origami topology is a trefoil knot, and its auxetic reconfiguration results in negative Poisson's ratios. This work shows the feasibility of deployable nanostructures, providing a versatile platform for topological studies and opening new opportunities for bioengineering.

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Section: S X Y = ⋅mentioning

confidence: 99%

Topological Assembly of a Deployable Hoberman Flight Ring from DNA

Chen

Choi

2021

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“…2 (f), respectively). An externally embedded Halleffect sensor array detects the suction cup's location; thus, the system completes both locomotion and adhesion activation autonomously, without human intervention (see [25] for details of navigation). Further system information will be given in Section II-D.…”

Section: A Elastomeric Suction Cup Designmentioning

confidence: 99%

“…Following our previous achievements in [24], [25] where a remotely controllable pill that can deploy, dress or plug, deliver a drug, and eventually biodegrade was presented, this study further advances the system by developing an autonomous suction-based adhesion mechanism for anchoring onto tissue and manipulating an object (Fig. 1).…”

Section: Introductionmentioning

confidence: 96%

Autonomous and Reversible Adhesion using Elastomeric Suction Cups for In-vivo Medical Treatments

Iwasaki

Lefevre

Damian

et al. 2020

IEEE Robot. Autom. Lett.

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“…In our previous work, we presented an ingestible origami patch that can be instantly deployed inside the stomach and visually guided to dislocate a harming button battery at a wound site [23]- [25]. As alternatives to visual tracking for the localization of magnetic robots, magnetic sensors provide a low-cost and efficient solution [9], [26]- [30]. The detection and localization of an ingested battery, on the other hand, is still a problem needing an accessible technique that does not depend on costly medical imaging modalities such as ultrasound, fluoroscopic imaging or MRI.…”

Section: Introductionmentioning

confidence: 99%