Programmable therapeutic nanoscale covalent organic framework for photodynamic therapy and hypoxia-activated cascade chemotherapy

He, Haozhe; Du, Lili; Xue, Hongman; Wu, Jun; Shuai, Xintao

doi:10.1016/j.actbio.2022.07.003

Cited by 32 publications

(15 citation statements)

References 49 publications

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“…(g) Curve of tumor growth inhibition, (h) tumor-bearing mice’s cumulative survival, and (i) tumor slides stained with HIF-1α in various treatment groups. Reproduced from ref with permission. Copyright (2022) Elsevier Ltd. (j) Schematic illustration of hypoxia-induced activation of Silicon(IV) phthalocyanine prodrug.…”

Section: Utilizing Hypoxiamentioning

confidence: 99%

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Pan,

Liu,

Mou

et al. 2023

ACS Nano

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Cancer with a complex pathological process is a major disease to human welfare. Due to the imbalance between oxygen (O 2 ) supply and consumption, hypoxia is a natural characteristic of most solid tumors and an important obstacle for cancer therapy, which is closely related to tumor proliferation, metastasis, and invasion. Various strategies to exploit the feature of tumor hypoxia have been developed in the past decade, which can be used to alleviate tumor hypoxia, or utilize the hypoxia for targeted delivery and diagnostic imaging. The strategies to alleviate tumor hypoxia include delivering O 2 , in situ O 2 generation, reprogramming the tumor vascular system, decreasing O 2 consumption, and inhibiting HIF-1 related pathways. On the other side, hypoxia can also be utilized for hypoxia-responsive chemical construction and hypoxia-active prodrug-based strategies. Taking advantage of hypoxia in the tumor region, a number of methods have been applied to identify and keep track of changes in tumor hypoxia. Herein, we thoroughly review the recent progress of nanomedicine strategies in both conquering and utilizing hypoxia to combat cancer and put forward the prospect of emerging nanomaterials for future clinical transformation, which hopes to provide perspectives in nanomaterials design.

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Section: Utilizing Hypoxiamentioning

confidence: 99%

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Pan,

Liu,

Mou

et al. 2023

ACS Nano

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“…As porphyrins can generate anticancer species 1 O 2 and raise the ambient temperature in response to near-infrared light, they are frequently utilized in the treatment of newly developed cancer and inflammatory disorders through PDT and PTT. − PBAs with their ability to self-assemble into different nanomaterials and encapsulate distinct active species (DOX, PTX, perfluorocarbon, gold nanoparticles) have significant potential in disease treatments.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Han,

Liu,

Peng

et al. 2023

Bioconjugate Chem.

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Porphyrins have been vastly explored and applied in many cutting-edge fields with plenty of encouraging achievements because of their excellent properties. As important derivatives of porphyrins, porphyrin-based amphiphiles (PBAs) not only maintain the advanced properties of porphyrins (catalysis, imaging, and energy transfer) but also possess self-assembly and encapsulation capability in aqueous solution. Accordingly, PBAs and their self-assembles have had important roles in diagnosing and treating tumors and inflammation lesions in vivo, but not limited to these. In this article, we introduce the research progress of PBAs, including their constitution, structure design strategies, and performances in tumor and inflammation lesion diagnosis and treatments. On that basis, the defects of synthesized PBAs during their application and the possible effective strategies to overcome the limitations are also proposed. Finally, perspectives on PBAs exploration are updated based on our knowledge. We hope this review will bring researchers from various domains insights about PBAs.

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“…However, tremendous advances in nanotechnology and biomaterials have enabled the possibility of proposing new strategies for combined therapy and regeneration by nano-incorporated hydrogels. [12][13][14] For example, injectable hydrogels, constructed through dynamic crosslinks, have been widely applied for direct injection into the cancer tissue and sustained drug release through prolonged maintenance of the hydrogel in the target site. In recent years, a number of natural polymers have been used to prepare injectable hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

et al. 2023

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Programmable therapeutic nanoscale covalent organic framework for photodynamic therapy and hypoxia-activated cascade chemotherapy

Cited by 32 publications

References 49 publications

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

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