No abstract

Ferroptosis is attracting significant attention due to its effectiveness in tumor treatment. The efficiency to produce toxic lipid peroxides (LPOs) at the tumor site plays a key role in ferroptosis. A hybrid PFP@Fe/Cu‐SS metal organic framework (MOF) is synthesized and shown to increase intratumoral LPO content through redox reactions generating ·OH. In addition, glutathione (GSH) depletion through disulfide‐thiol exchange leads to the inactivation of glutathione peroxide 4 (GPX4), which results in a further increase in LPO content. This MOF exhibits high inhibitory effect on the growth of xenografted Huh‐7 tumors in mice. The coadministration of a ferroptosis inhibitor reduces the antitumor effect of the MOF, leading to a restoration of GPX4 activity and an increase in tumor growth. Moreover, the construction of Cu into mesoporous PFP@Fe/Cu‐SS not only allows the MOF to be used as a contrast agent for T1‐weighted magnetic resonance imaging, but also renders its photothermal conversion capacity. Thus, near‐infrared irradiation is able to induce photothermal therapy and transform the encapsulated liquid perfluoropentane into microbubbles for ultrasound imaging.

Using Global Precipitation Climatology Project daily rainfall and ERA interim reanalysis data, we investigate the distinct characteristic of quasi-biweekly variation (QBV: 12-20 days) over East Asia (EA) during early (June 10-July 20) and late (July 21-August 31) summer. The QBV maximum variance is found over the core region of EA (30°-40°N, 110°-130°E), which includes eastern China (lower reaches of the Yellow, Huaihe, and Yangtze rivers) and the Korean Peninsula. At both its peak wet and dry phases, QBV over the core region has a baroclinic structure, but with different spatial distributions, different lower-level prevalent wind anomalies, and different upperlevel major circulation anomalies in the two subseasons. Meanwhile, the two subseasons have different propagating tracks prior to reaching the peak phase, and different precursors associated with the local genesis of QBV. Furthermore, during the transition from the peak dry to peak wet phase of QBV, the major monsoon circulations have different behaviors that tropical monsoon trough extends eastward in early summer but retreats westward in late summer and the South Asia high (SAH) and western North Pacific (WNP) subtropical high move toward (away from) each other in early (late) summer. The abrupt change of mean state in mid to late July, which includes the northward migration of westerly jet, SAH and WNP, and the weakening and broken of westerly jet, is considered the root cause of the change in behavior of QBV. Finally, we indicate that the tropical monsoon trough and midlatitude westerly jet are possible sources of QBV over subtropical EA in both subseasons and provide useful guidance for 2-3 week predictions over EA.

The development of a simple and straightforward strategy to synthesize multifunctional carbon dots for photodynamic therapy (PDT) has been an emerging focus. In this work, diketopyrrolopyrrole-based fluorescent carbon dots (DPP CDs) were designed and synthesized through a facile one-pot hydrothermal method by using diketopyrrolopyrrole (DPP) and chitosan (CTS) as raw materials. DPP CDs not only maintained the ability of DPP to generate singlet oxygen (1O2) but also have excellent hydrophilic properties and outstanding biocompatibility. In vitro and in vivo experiments demonstrated that DPP CDs greatly inhibited the growth of tumor cells under laser irradiation (540 nm). This study highlights the potential of the rational design of CDs for efficient cancer therapy.