Diketopyrrolopyrrole-based carbon dots for photodynamic therapy

He, Haozhe; Zheng, Xiaohua; Liu, Shi; Zheng, Min; Xie, Zhigang; Wang, Yong; Yu, Meng; Shuai, Xintao

doi:10.1039/c8nr02643b

Cited by 114 publications

(55 citation statements)

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“…Carbon dot (CD) is as mallc arbon nanoparticle with size of less than 10 nm and at ype of 0Dm aterialthat consistsofacarbogenic core and surface functional groups. [1] Due to the unique advantages, including excellent photoluminescence, high biocompatibility, [2] tunables urface functionalities, robust chemical inertness, and life full photo-physical properties, [3] CDs are widely applied in sensors, bioimaging, [4] drug delivery,p hotodynamic therapy (PDT), [5] and photothermal therapy (PTT). [6] Initially,C Ds as auxiliary theranostic reagents have been concerted with chemical drugs, [7] genes, [8] and some traditional photosensitizers.…”

Section: Introductionmentioning

confidence: 99%

Pheophytin Derived Near‐Infrared‐Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy

Wen

Jia

Nan

et al. 2019

Chemistry An Asian Journal

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Carbon dots (CDs), a kind of phototheranostic agent with the capability of simultaneous bioimaging and phototherapy [i.e., photodynamic therapy (PDT) or photothermal therapy (PTT)], have received considerable attention because of their remarkable properties, including flexibility for surface modification, high biocompatibility, low toxicity and photo‐induced activity for malignant tumor cells. Among numerous carbon sources, it has been found that natural biomass are good candidates for the preparation of CD phototheranostic agents. In this study, pheophytin, a type of Mg‐free chlorophyll derivative and also a natural product with low toxicity, was used as a raw carbon source for the synthesis of CDs by using a microwave method. The obtained hydrophobic CDs exhibited a maximum near‐infrared (NIR) emission peak at approximately 680 nm, and high singlet oxygen (1O2) generation with a quantum yield of 0.62. The self‐assembled CDs from the as‐prepared CDs with DSPE‐mPEG2000 retained efficient 1O2 generation. The obtained carbon dot assembly was not only an efficient fluorescence (FL) imaging agent but also a smart PDT agent. Our studies indicated that the obtained hydrophilic CD assembly holds great potential as a new phototheranostic agent for cancer therapy. This work provides a new route for synthesis of CDs and proposes a readily available candidate for tumor treatment.

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Section: Introductionmentioning

confidence: 99%

Pheophytin Derived Near‐Infrared‐Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy

Wen

Jia

Nan

et al. 2019

Chemistry An Asian Journal

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Section: Cds For Tumor Theranosticsmentioning

confidence: 99%

“…However, these organic PSs may be good carbon sources for CDs, and the best solution is to revolve the above disadvantages while retaining photodynamic properties through synthesis. Shuai and co‐workers designed and synthesized DPP‐based fluorescent CDs (DPP–CDs) by the hydrothermal method, using DPP and chitosan as precursors (Figure b) . The DPP–CDs could not only maintain the capability of generating 1 O 2 but also have excellent hydrophilic properties and biocompatibility; the DPP–CDs could effectively inhibit tumor growth under laser irradiation (540 nm) in in vitro and in vivo experiments.…”

Section: Cds For Tumor Theranosticsmentioning

confidence: 99%

Carbon Dots for In Vivo Bioimaging and Theranostics

Fan

et al. 2019

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Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy and diagnostics, CDs are good candidates when they are combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development of CDs in nanomedicine is reviewed from their use as original imaging agents and/or drug carriers to multifunctional theranostic systems. Finally, the challenges and prospects of the next‐generation of CD‐based theranostics for clinical applications are also discussed.

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“…Therefore, it is not surprising that CDs have gained relevance in various fields, such as sensing [17][18][19][20], bioimaging [21], photocatalysis [10], drug delivery [22], solar cells [23], and photodynamic therapy [24].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Different Bottom-up Routes for the Fabrication of Carbon Dots

Crista

Silva

2020

Nanomaterials

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Carbon dots (CDs) are carbon-based nanoparticles with very attractive luminescence features. Furthermore, their synthesis by bottom-up strategies is quite flexible, as tuning the reaction precursors and synthesis procedures can lead to an endless number of CDs with distinct properties and applications. However, this complex variability has made the characterization of the structural and optical properties of the nanomaterials difficult. Herein, we performed a systematic evaluation of the effect of three representative bottom-up strategies (hydrothermal, microwave-assisted, and calcination) on the properties of CDs prepared from the same precursors (citric acid and urea). Our results revealed that these synthesis routes led to nanoparticles with similar sizes, identical excitation-dependent blue-to-green emission, and similar surface-functionalization. However, we have also found that microwave and calcination strategies are more efficient towards nitrogen-doping than hydrothermal synthesis, and thus, the former routes are able to generate CDs with significantly higher fluorescence quantum yields than the latter. Furthermore, the different synthesis strategies appear to have a role in the origin of the photoluminescence of the CDs, as hydrothermal-based nanoparticles present an emission more dependent on surface states, while microwave- and calcination-based CDs present an emission with more contributions from core states. Furthermore, calcination and microwave routes are more suitable for high-yield synthesis (~27–29%), while hydrothermal synthesis present almost negligible synthesis yields (~2%). Finally, life cycle assessment (LCA) was performed to investigate the sustainability of these processes and indicated microwave synthesis as the best choice for future studies.

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Diketopyrrolopyrrole-based carbon dots for photodynamic therapy

Cited by 114 publications

References 50 publications

Pheophytin Derived Near‐Infrared‐Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy

Pheophytin Derived Near‐Infrared‐Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy

Carbon Dots for In Vivo Bioimaging and Theranostics

Evaluation of Different Bottom-up Routes for the Fabrication of Carbon Dots

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