Programmed Bacteria Death Induced by Carbon Dots with Different Surface Charge

Bing, Wei; Sun, Hanjun; Yan, Zhengqing; Ren, Jinsong; Qu, Xiaogang

doi:10.1002/smll.201600294

Cited by 236 publications

(154 citation statements)

References 34 publications

(54 reference statements)

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…As the results, only for NER bacterial strain, 0.1 mg mL −1 performs better than 0.25 mg mL −1 . In the case of WT and BER bacterial strains, factors such as oxidation stress and DNA damage other than direct interaction with cell membrane may also be responsible for the bacterial cell fetal …”

Section: Resultsmentioning

confidence: 99%

“…In the case of WT and BER bacterial strains, factors such as oxidation stress and DNA damage other than direct interaction with cell membrane may also be responsible for the bacterial cell fetal. [32] As for the role of the UV irradiation, it is generally believed that UV radiation may induce ROS with or without the aid of C-dots. The observation by our other data generally indicates that NER is most vulnerable toward UV irradiation than BER.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

View full text Add to dashboard Cite

Carbon nanodots (C‐dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C‐dots can enhance targeted cancer therapy. However, in‐depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit‐derived C‐dots, exhibits significant DNA damage; Annexin V/7‐AAD‐mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C‐dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit‐derived C‐dots are observed inhibiting the horseradish peroxidase. Moreover, the C‐dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim‐1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C‐dots, derived from the date‐pit, as an efficient, low‐cost, and green nanomaterial are reveled for cancer therapy and anti‐infection.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

View full text Add to dashboard Cite

show abstract

“…As shown by the infrared spectra in Figure 1f, Gly‐CDs were similar to glycyrrhizic acid in structure, with most functional groups of glycyrrhizic acid being maintained during the formation of Gly‐CDs. However, Gly‐CDs have large surface area and more contact sites as compared with glycyrrhizic acid, leading to polyvalent interactions with the virus and thus higher antiviral activity than glycyrrhizic acid, similar to the enhanced antiviral activity of gold nanoparticles capped with mercaptoethanesulfonate 79,80. The TEM images of PRRSV with and without Gly‐CDs (Figure S10, Supporting Information) also proved that Gly‐CDs could interact with PRRSV directly, which may result in inhibition of PRRSV proliferation.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Tong

Zhou

et al. 2020

Small

180

165

View full text Add to dashboard Cite

With the gradual usage of carbon dots (CDs) in the area of antiviral research, attempts have been stepped up to develop new antiviral CDs with high biocompatibility and antiviral effects. In this study, a kind of highly biocompatible CDs (Gly‐CDs) is synthesized from active ingredient (glycyrrhizic acid) of Chinese herbal medicine by a hydrothermal method. Using the porcine reproductive and respiratory syndrome virus (PRRSV) as a model, it is found that the Gly‐CDs inhibit PRRSV proliferation by up to 5 orders of viral titers. Detailed investigations reveal that Gly‐CDs can inhibit PRRSV invasion and replication, stimulate antiviral innate immune responses, and inhibit the accumulation of intracellular reactive oxygen species (ROS) caused by PRRSV infection. Proteomics analysis demonstrates that Gly‐CDs can stimulate cells to regulate the expression of some host restriction factors, including DDX53 and NOS3, which are directly related to PRRSV proliferation. Moreover, it is found that Gly‐CDs also remarkably suppress the propagation of other viruses, such as pseudorabies virus (PRV) and porcine epidemic diarrhea virus (PEDV), suggesting the broad antiviral activity of Gly‐CDs. The integrated results demonstrate that Gly‐CDs possess extraordinary antiviral activity with multisite inhibition mechanisms, providing a promising candidate for alternative therapy for PRRSV infection.

show abstract

“…Interest in carbon dots (CDs) has increased in recent years due to their simple manufacturing process and unique properties, such as high quantum yield (QY), low toxicity, excellent water solubility, small size, high photostability, and so on . Therefore, they have wide potential applications in many fields, including fluorescent ink, bioimaging, antibacterial activity, optoelectronic devices, and more . However, most of the known CDs show blue light to green light emission under the excitation of ultraviolet (UV) light or blue light, which restrict their further applications in biomedicine and in optoelectronic devices.…”

Section: Introductionmentioning

confidence: 99%

One‐Step Hydrothermal Synthesis of Nitrogen‐Doped Conjugated Carbonized Polymer Dots with 31% Efficient Red Emission for In Vivo Imaging

Liu

Zhang

et al. 2018

Small

366

251

View full text Add to dashboard Cite

Carbon dots with long-wavelength emissions, high quantum yield (QY) and good biocompatibility are highly desirable for biomedical applications. Herein, a green, facile hydrothermal synthesis of highly efficient red emissive nitrogen-doped carbonized polymer dots (CPDs) with optimal emission at around 630 nm are reported. The red emissive CPDs possess a variety of superior properties including excellent water dispersibility, good biocompatibility, narrow bandwidth emission, an excitation-independent emission, and high QY (10.83% (in water) and 31.54% (in ethanol)). Further studies prove that such strong red fluorescence is ascribed to the efficient conjugated aromatic π systems and hydrogen bonds of CPDs. And the fluorescence properties of CPDs can be regulated by adjusting the dosage of HNO before the reaction. Additionally, the as-prepared CPDs are successfully used as a fluorescent probe for bioimaging, both in vitro and in vivo. More importantly, biodistribution results demonstrate that most CPDs and their metabolites are not only excreted in urine but also excreted by hepatobiliary system in a rapid manner. Besides, the CPDs could easily cross the blood brain barrier, which may provide a valuable strategy for the theranostics of some brain diseases through real-time tracking.

show abstract

Programmed Bacteria Death Induced by Carbon Dots with Different Surface Charge

Cited by 236 publications

References 34 publications

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

One‐Step Hydrothermal Synthesis of Nitrogen‐Doped Conjugated Carbonized Polymer Dots with 31% Efficient Red Emission for In Vivo Imaging

Contact Info

Product

Resources

About