Progress in Cyclizations of 4‐Acetylenic Ketones: Synthesis of Furans and Pyrroles

Abstract

4‐Acetylenic ketones are a class of useful and important synthons with functionalized alkynes and carbonyl groups in one molecular skeleton. They displayed unique reactivity via cyclizations that provided access to multi‐functional furans and pyrroles. This minireview offers a comprehensive coverage of the development of their multifaceted reactivity for synthetic applications in furans and pyrroles.

Synthesis, structure, and catalytic performance of solvent induced zinc clusters in furan synthesis by cycloisomerization reaction

“…Despite the effectiveness of this method for the synthesis of various furan derivatives, the use of catalysts is one of the challenging requirements in this field. In recent years, a variety of catalysts based on transition metal ions like Ag(I), 19 Pd(II), 20 Au(I), 21 Hg(II), 22 and Zn(II) 23 ions have been used for this transformation. The use of inexpensive, green, non‐toxic, and readily available metallic catalysts is favorable and one of the goals in designing catalytic systems 24 .…”

Palladium Iodide Catalyzed Multicomponent Carbonylative Synthesis of 2-(4-Acylfuran-2-yl)acetamides

“…Among the synthetic methods available to prepare multisubstituted furans (for recent reviews, see references [5][6][7]), transition metal-catalyzed cyclization (TMCC) of suitable acyclic precursors is particularly attractive (for recent reviews, see references [8,9]; for a book, see reference [10]; for a recent example, see reference [11]). By this approach, the final compound with the desired substitution pattern can be obtained in one synthetic step starting from readily available substrates.…”