Progress in Depsipeptide‐Based Biomaterials

Amphiphilic block copolymers containing biodegradable hydrophobic segments of depsipeptide based copolymers have been synthesized and explored as gene carriers for enhancing proliferation of endothelial cells in vitro. These polymers form nanoparticles (NPs) with positive charges on their surface, which could condense recombinant plasmids of enhanced green fluorescent protein plasmid and ZNF580 gene (pEGFP-ZNF580) and protect them against DNase I. ZNF580 gene is efficiently transported into EA.hy926 cells to promote their proliferation, whereby the transfection efficiency of NPs/pEGFP-ZNF580 is approximately similar to that of Lipofectamine 2000. These results indicate that the NPs might have potential as a carrier for pEGFP-ZNF580, which could support endothelialization of cardiovascular implants.

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“…The block copolymers with lower crystalline degree degraded faster than PLA (Table S1, Supporting Information). [ 57 ] …”

Section: Degradation Of P(la-co-mmd) 2 Copolymermentioning

confidence: 99%

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Shi

Zhang

et al. 2015

Adv Healthcare Materials

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“…15 Polydepsipeptides (PDPs), which are copolymers of a-hydroxy acids Additional Supporting Information may be found in the online version of this article. and a-amino acids, are an important class of the poly(ester amide)s. 16 PDPs can be synthesized via ring-opening polymerization (ROP) of morpholine-2,5-dione (MD) monomers, which are six-membered rings composed of a single a-amino acid and a single a-hydroxy acid residue.…”

mentioning

confidence: 99%

Biodegradable photocrosslinkable poly(depsipeptide‐co‐ε‐caprolactone) for tissue engineering: Synthesis, characterization, and In vitro evaluation

Elomaa

Kang

Seppälä

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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Stereolithography has become increasingly popular in scaffold fabrication due to automation and well-controlled geometry complexity, and consequently, there is a great need for new suitable biodegradable photocrosslinkable polymers. In this study, a new type of photocrosslinkable poly(ester amide) was synthesized based on e-caprolactone and L-alaninederived depsipeptide and was applied to fabrication of threedimensional (3D) scaffolds by stereolithography. 1 H nuclear magnetic resonance and Fourier transform infra-red analysis confirmed the formation of new bonds during the polymer synthesis. Incorporation of depsipeptide increased the glass transition temperature and hydrophilicity of the polymer and accelerated hydrolytic degradation compared with the poly(ecaprolactone) homopolymer. The compressive strength of the 3D scaffolds increased with the increasing depsipeptide content. This work demonstrated that incorporation of depsipeptide into photocrosslinkable polyesters resulted in excellent cytocompatibility and tunable degradation rates and mechanical properties and thus expanded the repertoire of biomaterials suitable for 3D photofabrication of high-resolution tissue engineering scaffolds.

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“…Natural polymers are derived from animals as well as plants and include polysaccharides, such as cellulose, chitin, starch, alginate, galactan, hyaluronic acid, dextran, and gellan,18 or protein-based carriers like albumin, gelatine, collagen, milk and silk proteins, soy proteins, and lectins 19,20. Polydepsipeptides are synthetic peptide polymers which are degraded into biocompatible amino acids 21. Their composition can be adjusted to achieve an optimal complexation of the loaded drug and to control their physicochemical properties such as hydrophobicity/hydrophilicity.…”

Section: Types Of Biodegradable Polymeric Ddsmentioning

confidence: 99%

Utilization of biodegradable polymeric materials as delivery agents in dermatology

Rancan

Blume-Peytavi

Vogt

2014

CCID

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Biodegradable polymeric materials are ideal carrier systems for biomedical applications. Features like controlled and sustained delivery, improved drug pharmacokinetics, reduced side effects and safe degradation make the use of these materials very attractive in a lot of medical fields, with dermatology included. A number of studies have shown that particle-based formulations can improve the skin penetration of topically applied drugs. However, for a successful translation of these promising results into a clinical application, a more rational approach is needed to take into account the different properties of diseased skin and the fate of these polymeric materials after topical application. In fact, each pathological skin condition poses different challenges and the way diseased skin interacts with polymeric carriers might be markedly different to that of healthy skin. In most inflammatory skin conditions, the skin’s barrier is impaired and the local immune system is activated. A better understanding of such mechanisms has the potential to improve the efficacy of carrier-based dermatotherapy. Such knowledge would allow the informed choice of the type of polymeric carrier depending on the skin condition to be treated, the type of drug to be loaded, and the desired release kinetics. Furthermore, a better control of polymer degradation and release properties in accordance with the skin environment would improve the safety and the selectivity of drug release. This review aims at summarizing the current knowledge on how polymeric delivery systems interact with healthy and diseased skin, giving an overview of the challenges that different pathological skin conditions pose to the development of safer and more specific dermatotherapies.

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Progress in Depsipeptide‐Based Biomaterials

Cited by 71 publications

References 94 publications

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Nanoparticles Complexed with Gene Vectors to Promote Proliferation of Human Vascular Endothelial Cells

Biodegradable photocrosslinkable poly(depsipeptide‐co‐ε‐caprolactone) for tissue engineering: Synthesis, characterization, and In vitro evaluation

Utilization of biodegradable polymeric materials as delivery agents in dermatology

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