Progress in heparin and heparin-like/mimicking polymer-functionalized biomedical membranes

Abstract

Research into the design of heparin and heparin-like/mimicking polymer-functionalized biomedical membranes is of tremendous interest to the biomedical sector in particular and is driven by potential diverse biomedical applications such as blood purification, artificial organs and other clinical medical devices. In this review, we highlight the progress of the recent research and propose potential biomedical applications in the fields of surface heparinization and the heparin-inspired modification of polymeric membranes. We summarize various surface heparinization strategies such as blending, surface coating, grafting, layer-by-layer assembly and mussel-inspired coating. Then, we classify the heparinlike/mimicking polymers and their applications in the design of heparin-mimicking biomedical membranes and draw some conclusions. The general concept of heparin-like/mimicking polymers is usually defined as heparan sulfates or synthetic sulfated/carboxylated polymers with comparable biologically mimicking functionalities as heparin, especially anticoagulant activity. Moreover, the potential biomedical applications and benefits of heparin and heparin-like/mimicking polymer-functionalized membranes in blood purification, artificial organs and tissue engineering are also discussed in each section. The heparin and heparin-like/mimicking polymer-functionalized membranes presented are Chong Cheng obtained his BS degree in 2010 from the Biomedical Engineering, College of Materials Science and Engineering, Sichuan University. Since June 2010, He became a Ph.D candidate in Biomedical Engineering, College of Polymer Science and Engineering, Sichuan University under the supervision of Prof. Changsheng Zhao. He is now doing visiting research work at University of Michigan under the supervision of Prof. Nicholas A. Kotov. His research interests include the blood and cell compatibility of polymeric hydrogels and composite biomaterials, biomedical lms/membranes for tissue engineering and regeneration medicine, self-assembly and biomimetic nanotechnology, and also the studies of biological functionalization and applications of nanomaterials, including nano/micro-gels, hybrid polymeric nanoparticles, carbon nanotubes and graphene. From 2010, his publication includes over 30 high quality papers in top material and chemical journals.

Preparation, characterization and antifouling properties of polyacrylonitrile/polyurethane blend membranes for water purification

“…However, its intensity vanishes at higher blend composition of PU i.e., the 70/30 and 60/40 membranes (Fig. 54,36 This result establishes the better compatibility between the individual polymers. Pure PU membrane ( Fig.…”

“…Zavastin et al 31 reported the successful application of PU/CA blend membranes in wastewater treatment in the textile industry. [34][35][36] In addition, better antifouling and antithrombotic properties using PES/PU composite membranes during dialysis was carried out by Yin et al 37 A recent report by Roy et al 38 showed that a PSF/PVP/PEG blend membrane was found to have adequate cyctocompatibility and blood compatibility for hemodialysis. The ux and protein rejection were increased for the blend ultraltration (UF) membranes with dimethylacetamide (DMAc) when compared to dimethylformamide (DMF) as a solvent.…”

Capturing red blood cells from the blood by lectin recognition on a glycopolymer-patterned surface

“…[28][29][30][31] The purified platelets are used as the models for platelet capture on the patterned surface. [28][29][30][31] The purified platelets are used as the models for platelet capture on the patterned surface.…”

Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility

“…Therefore, much attention has been paid to developing new synthetic macromolecules to replace heparin . It is believed that the bioactivity of heparin is mainly caused by the active sequence of pentasaccharide, molecular conformation, and ionic functional groups (sulfonate, sulfamide, and carboxylate) . Recent studies indicated that polymers with sulfonate, sulfamide, and/or carboxylate as pendant groups possess partial functions of heparin, such as anticoagulant ability and cell affinity .…”