Progress in polymer nanocomposites for bone regeneration and engineering

Idumah, Christopher Igwe

doi:10.1177/0967391120913658

Cited by 85 publications

(19 citation statements)

References 126 publications

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“… 10 , 47 , 48 These microfibers have a cotton candy like structure imitating a fibrin clot microstructure. 118 Human trials indicated that chronic wounds, such as diabetic foot ulcers and bedsores, healed in 6–10 weeks after application of Mirragen microfibers. 119 − 121 This technology is described to be an effective treatment for wounds which exhibit no healing with conventional treatment options.…”

Section: Applications Of Bbgsmentioning

confidence: 99%

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Ege

Zheng

Boccaccını

2022

ACS Appl. Bio Mater.

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Since the early 2000s, borate bioactive glasses (BBGs) have been extensively investigated for biomedical applications. The research so far indicates that BBGs frequently exhibit superior bioactivity and bone healing capacity compared to silicate glasses. They are also suitable candidates as drug delivery devices for infection or disease treatment such as osteoporosis. Additionally, BBGs are also an excellent option for wound healing applications, which includes the availability of commercial (FDA approved) microfibrous BBG dressings to treat chronic wounds. By addition of modifying ions, the bone or wound healing capacity of BBGs can be enhanced. For instance, addition of copper ions into BBGs was shown to drastically increase blood vessel formation for wound healing applications. Moreover, addition of ions such as magnesium, strontium, and cobalt improves bone healing. Other recent research interest related to BBGs is focused on nerve and muscle regeneration applications, while cartilage regeneration is also suggested as a potential application field for BBGs. BBGs are commonly produced by melt-quenching; however, sol–gel processing of BBGs is emerging and appears to be a promising alternative. In this review paper, the physical and biological characteristics of BBGs are analyzed based on the available literature, the applications of BBGs are discussed, and future research directions are suggested.

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Section: Applications Of Bbgsmentioning

confidence: 99%

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Ege

Zheng

Boccaccını

2022

ACS Appl. Bio Mater.

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“…As bone matrix is a combination of organic (mainly collagen) and inorganic (apatite) composite materials, it seems logical to combine polymers and hydroxyapatite (HA) to develop scaffolds that meet all the desired requirements for bone applications [10][11][12][13][14][15]. HA is widely used in bone tissue engineering to enhance bioactivity, osteoconductivity, and osteoblast differentiation [16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Pellet-Based Fused Filament Fabrication (FFF)-Derived Process for the Development of Polylactic Acid/Hydroxyapatite Scaffolds Dedicated to Bone Regeneration

et al. 2022

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Scaffolds can be defined as 3D architectures with specific features (surface properties, porosity, rigidity, biodegradability, etc.) that help cells to attach, proliferate, and to differentiate into specific lineage. For bone regeneration, rather high mechanical properties are required. That is why polylactic acid (PLA) and PLA/hydroxyapatite (HA) scaffolds (10 wt.%) were produced by a peculiar fused filament fabrication (FFF)-derived process. The effect of the addition of HA particles in the scaffolds was investigated in terms of morphology, biological properties, and biodegradation behavior. It was found that the scaffolds were biocompatible and that cells managed to attach and proliferate. Biodegradability was assessed over a 5-month period (according to the ISO 13781-Biodegradability norm) through gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and compression tests. The results revealed that the presence of HA in the scaffolds induced a faster and more complete polymer biodegradation, with a gradual decrease in the molar mass (Mn) and compressive mechanical properties over time. In contrast, the Mn of PLA only decreased during the processing steps to obtain scaffolds (extrusion + 3D-printing) but PLA scaffolds did not degrade during conditioning, which was highlighted by a high retention of the mechanical properties of the scaffolds after conditioning.

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“…Polymer nanocomposites with nano-sized carbonaceous fillers have attracted attention due to improvements in mechanical properties and conductivity when compared to the original polymer [9,10]. The development of well-dispersed graphene nanoparticles (GPN) in a polymeric matrix has opened a new and interesting topic in materials science [11].…”

Section: Introductionmentioning

confidence: 99%

Additive Manufactured Poly(ε-caprolactone)-graphene Scaffolds: Lamellar Crystal Orientation, Mechanical Properties and Biological Performance

et al. 2022

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Understanding the mechano–biological coupling mechanisms of biomaterials for tissue engineering is of major importance to assure proper scaffold performance in situ. Therefore, it is of paramount importance to establish correlations between biomaterials, their processing conditions, and their mechanical behaviour, as well as their biological performance. With this work, it was possible to infer a correlation between the addition of graphene nanoparticles (GPN) in a concentration of 0.25, 0.5, and 0.75% (w/w) (GPN0.25, GPN0.5, and GPN0.75, respectively) in three-dimensional poly(ε-caprolactone) (PCL)-based scaffolds, the extrusion-based processing parameters, and the lamellar crystal orientation through small-angle X-ray scattering experiments of extruded samples of PCL and PCL/GPN. Results revealed a significant impact on the scaffold’s mechanical properties to a maximum of 0.5% of GPN content, with a significant improvement in the compressive modulus of 59 MPa to 93 MPa. In vitro cell culture experiments showed the scaffold’s ability to support the adhesion and proliferation of L929 fibroblasts (fold increase of 28, 22, 23, and 13 at day 13 (in relation to day 1) for PCL, GPN0.25, GPN0.5, and GPN0.75, respectively) and bone marrow mesenchymal stem/stromal cells (seven-fold increase for all sample groups at day 21 in relation to day 1). Moreover, the cells maintained high viability, regular morphology, and migration capacity in all the different experimental groups, assuring the potential of PCL/GPN scaffolds for tissue engineering (TE) applications.

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Progress in polymer nanocomposites for bone regeneration and engineering

Cited by 85 publications

References 126 publications

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions

Pellet-Based Fused Filament Fabrication (FFF)-Derived Process for the Development of Polylactic Acid/Hydroxyapatite Scaffolds Dedicated to Bone Regeneration

Additive Manufactured Poly(ε-caprolactone)-graphene Scaffolds: Lamellar Crystal Orientation, Mechanical Properties and Biological Performance

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