Progress in the diagnosis and therapy of melanoma

Wiesner, Thomas; Zbyszewski, A.

doi:10.1111/bjd.16110

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…1,2 In metastatic disease, immune checkpoint inhibitors and targeted therapies have significantly improved progression-free and overall survival. 3,4 To the present date, it is almost impossible to predict which patient will benefit from a sustained treatment response. 3,4 To the present date, it is almost impossible to predict which patient will benefit from a sustained treatment response.…”

Section: Introductionmentioning

confidence: 99%

“…3 However, after initial response, therapy resistances, leading to progression, are frequently observed. 3,4 To the present date, it is almost impossible to predict which patient will benefit from a sustained treatment response. Hence, novel therapy targets, prognostic and predictive markers are strongly needed to further improve melanoma treatment.…”

Section: Introductionmentioning

confidence: 99%

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G protein‐coupled receptor 40 expression in human melanoma – correlation with tumour thickness, AJCC stage and survival

Kleemann

Hrgović

Kleimann

et al. 2019

Acad Dermatol Venereol

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Background In melanoma, preclinical data suggest a possible role of polyunsaturated fatty acids inhibiting cell growth. A new target molecule for free fatty acids, the G protein‐coupled receptor GPR40, was identified in melanoma cells. Objectives The aim of this study was to investigate GPR40 expression in human melanocytic tissues and to evaluate its potential as a prognostic marker. Methods and Results A total of 114 tissue sections of naevi, primary melanoma and melanoma metastasis were immunohistochemically stained with anti‐GPR40. The staining was evaluated, using the immunoreactivity scoring system. Compared to naevi, primary melanoma and melanoma metastasis showed significantly higher levels of GPR40 (P < 0.05). In primary melanoma, GPR40 expression positively correlated with tumour thickness (P = 0.044) and AJCC level (P = 0.017) and in melanoma metastasis with AJCC level (P = 0.035). Primary melanoma patients with high levels of GPR40 had a significantly poorer overall survival (P = 0.004) and shorter disease‐free survival (0.040). Conclusion The present study identified GPR40 as a novel target molecule in melanoma. First evidence for a potential role of the receptor in tumour progression and metastases was found, and it could be demonstrated that GPR40 expression is negatively correlated with patient's survival.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

G protein‐coupled receptor 40 expression in human melanoma – correlation with tumour thickness, AJCC stage and survival

Kleemann

Hrgović

Kleimann

et al. 2019

Acad Dermatol Venereol

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“…several therapeutic agents have been recently approved (Leonardi et al, 2018;Malas et al, 2014;Ross & Gershenwald, 2011). Despite progress in advanced malignant melanoma therapy, the patient prognosis remains poor (Wiesner & Zbyszewski, 2018). The identification of reliable biomarkers represents therefore a primary goal.…”

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confidence: 99%

Nicotinamide N‐methyltransferase gene silencing enhances chemosensitivity of melanoma cell lines

Campagna

Salvolini

Pompei

et al. 2021

Pigment Cell Melanoma Res

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Melanoma arises from the transformation of cutaneous or mucous melanocytes. Cutaneous malignant melanoma represents less than 5% of all malignant skin neoplasms but, despite the low incidence, it is responsible for the majority of skin cancer-related deaths, due to its tendency to metastasize (Erdei & Torres, 2010;Ossio et al., 2017).Its incidence varies greatly between countries and shows a steady increase (Leonardi et al., 2018). Ultraviolet radiation exposure represents the main environmental risk factor, although host risks factors, such as genetic predisposition and the number of nevi, play an important role in tumor development (Leonardi et al., 2018).If melanoma is diagnosed at an early stage, surgical excision is curative in the majority of cases (Ross & Gershenwald, 2011).Unfortunately, approximately 10% of neoplasms are detected at an advanced stage. These lesions are more difficult to treat although

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