Progress in treatment of viral infections in children with acute lymphoblastic leukemia

Moschovi, Maria; Adamaki, Maria; Vlahopoulos, Spiros

doi:10.4081/oncol.2016.300

Cited by 12 publications

(12 citation statements)

References 122 publications

(115 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In dendritic cells, autophagy that leads to MHC-I depletion decreases their efficiency in stimulating CD8 + T cells against the influenza virus. 254 What appears consistent between the lupus and cancer studies is the critical role played not only by macrophage polarizing conditions but also by the T-helper phenotype. 251 However, in the presence of a fully functional immune system, low-dose CQ (10 mg/kg) could trigger potent IFN-c-associated immune responses against irradiated tumors, thereby protecting mice from further tumor challenge.…”

Section: Impact Of Cq On Antitumor Immune Responsesmentioning

confidence: 82%

“…The capacity of CQ to stimulate immune responses can be extended to eliciting antiviral as well as antitumor activity in the clinical setting. 254 What appears consistent between the lupus and cancer studies is the critical role played not only by macrophage polarizing conditions but also by the T-helper phenotype.…”

Section: Impact Of Cq On Antitumor Immune Responsesmentioning

confidence: 82%

See 1 more Smart Citation

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

2019

Self Cite

View full text Add to dashboard Cite

Chloroquines are 4-aminoquinoline-based drugs mainly used to treat malaria. At pharmacological concentrations, they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell. In addition to affecting cellular metabolism and bioenergetic flow equilibrium, autophagy plays a pivotal role at the interface between inflammation and cancer progression. Chloroquines consequently have critical effects in tissue metabolic activity and importantly, in key functions of the immune system. In this article, we will review the work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy.

show abstract

Section: Impact Of Cq On Antitumor Immune Responsesmentioning

confidence: 82%

Section: Impact Of Cq On Antitumor Immune Responsesmentioning

confidence: 82%

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…This virus spreads easily in pediatric oncology departments from both visitors and health care workers. [ 1 , 8 ]…”

Section: Discussionmentioning

confidence: 99%

Diagnostic difficulties of AH1N1 influenza infection in children with acute lymphoblastic leukemia

Zawitkowska¹,

Lejman

Drabko³

et al. 2020

Medicine

View full text Add to dashboard Cite

Introduction: Children with acute lymphoblastic leukemia (ALL) are at a risk of developing influenza-related complications. Approximately 10% of influenza-infected children with ALL or other types of cancer need intensive care, and 5% of them eventually die. Patients’ concerns: We report 2 children with ALL and the swine-origin influenza A virus infection. Diagnosing influenza in them was a challenge. Medical records of these children were reviewed for demographic, clinical, and laboratory data. Patients were hospitalized in the Department of Pediatric Hematology, Oncology, and Transplantology of the Medical University of Lublin, Poland. Case 1 involved a 2-year-old girl who, according to acute lymphoblastic leukemia intercontinental Berlin-Frankfürt-Münster protocol 2009, started chemotherapy in July 2015. She was categorized in the intermediate risk group and received the induction and consolidation phase of the therapy without severe complications. The reinduction therapy was administered in the outpatient department till the 15 th day. On the 20 th day of this phase, she was admitted to our department with fever, mucositis, tachypnea, abdominal pain, and diarrhea. In September 2009, a 14-year-old boy (case 2) who, according to acute lymphoblastic leukemia intercontinental Berlin-Frankfürt-Münster protocol 2002, was categorized in the high-risk (HR) group, received the induction (Protocol I) phase of therapy without severe complications. On the 7 th day of the HR-1 course, he manifested fever and strong, tiring cough, followed by strong mucositis. Chemotherapy had to be interrupted in both children. Diagnosis: Respiratory viral infections, causing pneumonia, occurred in both patients during anticancer treatment. Initially, the real-time polymerase chain reaction test for the swine-origin influenza A was negative in both patients, which delayed the diagnosis. Additionally, bacterial, and fungal complications were also observed. Interventions: Both patients received oseltamivir twice a day, a broad-spectrum antibiotic, antifungal drug, and granulocyte colony growth factor. Outcomes: The disease progressed quickly, and our patients subsequently died. Conclusion: We speculated that early antiviral treatment can help in the better management of patients in the HR group. It is also important to minimize influenza morbidity and mortality by vaccinating family members, using empiric therapy, providing immediate antiviral therapy, and educating parents about hygiene measures.

show abstract

“…For the cytokine modulation of T-cell activity, several viruses secrete homologs of human cytokines such as IL-10, to impede antiviral immunity 116 . The limits of cytokine expression in macrophages and T-cells, are largely dependent on the regulation of NF-κB 75 , 117 .…”

Section: Interacting Agents Of Nf-κb Direct Immune System Activitymentioning

confidence: 99%

Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

Vlahopoulos

2017

Cancer Biology & Medicine

View full text Add to dashboard Cite

The role of the transcription factor NF-κB in shaping the cancer microenvironment is becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF-κB function, and causes extensive changes in genomic chromatin that ultimately drastically alter cell-specific gene expression. NF-κB regulates the expression of cytokines and adhesion factors that control interactions among adjacent cells. As such, NF-κB fine tunes tissue cellular composition, as well as tissues' interactions with the immune system. Therefore, NF-κB changes the cell response to hormones and to contact with neighboring cells. Activating NF-κB confers transcriptional and phenotypic plasticity to a cell and thereby enables profound local changes in tissue function and composition. Research suggests that the regulation of NF-κB target genes is specifically altered in cancer. Such alterations occur not only due to mutations of NF-κB regulatory proteins, but also because of changes in the activity of specific proteostatic modules and metabolic pathways. This article describes the molecular mode of NF-κB regulation with a few characteristic examples of target genes.

show abstract

Progress in treatment of viral infections in children with acute lymphoblastic leukemia

Cited by 12 publications

References 122 publications

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

Diagnostic difficulties of AH1N1 influenza infection in children with acute lymphoblastic leukemia

Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

Contact Info

Product

Resources

About