Progress of gelatin-based microspheres (GMSs) as delivery vehicles of drug and cell

Dong, Zuoxiang; Meng, Xinyue; Yang, Wei; Zhang, Jinfeng; Sun, Peng; Zhang, Huawei; Fang, Xing; Wang, Dong‐An; Fan, Changjiang

doi:10.1016/j.msec.2021.111949

Cited by 53 publications

(25 citation statements)

References 216 publications

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“…Due to the instability and easy oxidation of FeS in aqueous solution, we improved the stability of FeS NPs by introducing gelatin into the reaction system [ 31 ]. As a biomedical material, gelatin has various attractive features, such as biocompatibility, low immunogenicity, biodegradability, and easy manipulation [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

et al. 2022

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Background The infection and spread of porcine reproductive and respiratory syndrome virus (PRRSV) pose a serious threat to the global pig industry, and inhibiting the viral infection process is a promising treatment strategy. Nanomaterials can interact with viruses and have attracted much attention due to their large specific surface area and unique physicochemical properties. Ferrous sulfide nanoparticles (FeS NPs) with the characteristics of high reactivity, large specific surface area, and low cost are widely applied to environmental remediation, catalysis, energy storage and medicine. However, there is no report on the application of FeS NPs in the antiviral field. In this study, gelatin stabilized FeS nanoparticles (Gel-FeS NPs) were large-scale synthesized rapidly by the one-pot method of co-precipitation of Fe2+ and S2‒. Results The prepared Gel-FeS NPs exhibited good stability and dispersibility with an average diameter of 47.3 nm. Additionally, they were characterized with good biocompatibility and high antiviral activity against PRRSV proliferation in the stages of adsorption, invasion, and replication. Conclusions We reported for the first time the virucidal and antiviral activity of Gel-FeS NPs. The synthesized Gel-FeS NPs exhibited good dispersibility and biocompatibility as well as effective inhibition on PRRSV proliferation. Moreover, the Fe2+ released from degraded Gel-FeS NPs still displayed an antiviral effect, demonstrating the advantage of Gel-FeS NPs as an antiviral nanomaterial compared to other nanomaterials. This work highlighted the antiviral effect of Gel-FeS NPs and provided a new strategy for ferrous-based nanoparticles against PRRSV. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

et al. 2022

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“…Although most electrospinning parameters have been studied in all the literature, none of these works investigated the effect of substrate temperature. Here, gelatin was chosen as a biopolymer for electrospinning because it is a commonly used biopolymer in many medical applications such as tissue engineering and drug delivery due to its biocompatible, bioactivity, and biodegradability [24,25]. Unfortunately, the gelatin electrospinning process is subject to some challenges because aqueous gelatin solutions are not electrospinnable, and the morphology of the electrospun gelatin depends on the concentration [26,27].…”

Section: Introductionmentioning

confidence: 99%

Influence of substrate temperature parameter on electrospinning process: example of application to the formation of gelatin fibers

Morsy

2022

Polym. Bull.

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The substrate temperature was investigated to broaden the applicability of controlling the morphology of polymeric fibers produced during the electrospinning process. A laboratory electrospinning setup was designed using a substrate heated in a temperature range of 25 °C to 100 °C. A gelatin polymer was used as an example to obtain beads-free gelatin fibers by fixing the main electrospinning parameters. Based on XRD, FTIR, and DSC techniques, the electrospun gelatin fibers did not show any change in their chemical composition up to 100 °C. Heating the substrate at 50 °C may be the best selection factor to obtain gelatin fibers; the fiber diameters experienced a significant decrease from 680 ± 140 nm to 420 ± 120 nm with increasing substrate temperature from 25 to 50 °C, respectively. They showed stability of the diameter at 380 ± 130 nm and 390 ± 130 nm when increasing substrate temperatures from 75 to 100 °C, respectively, with a significant variation in their diameter distribution. Therefore, this ability to control the electrospinning process using a heated substrate makes it promising for fabricating electrospun beads-free fibers of biopolymers such as gelatin for tissue engineering and drug delivery carriers.

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“…Microspheres are spherical shells that are commonly formulated from biodegradable or resorbable polymers. They possess a very small diameter, generally in the micrometre range [ 120 ]. This type of system displays unique features, such as high drug load capacity, site-specific action, controlled drug release, and good stability (thermally, physically, and chemically).…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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Progress of gelatin-based microspheres (GMSs) as delivery vehicles of drug and cell

Cited by 53 publications

References 216 publications

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

Inhibitory effect and mechanism of gelatin stabilized ferrous sulfide nanoparticles on porcine reproductive and respiratory syndrome virus

Influence of substrate temperature parameter on electrospinning process: example of application to the formation of gelatin fibers

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

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