Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury

Gao, Shuhan; Chen, Xiaojing; Yu, Zhiqian; Du, Rong; Chen, Baizhong; Wang, Yuxin; Cai, Xiao-Ting; Xu, Jiepei; Chen, Jiamin; Duan, Huiying; Cai, Yi; Zheng, Guodong

doi:10.1016/j.phymed.2023.154836

Cited by 21 publications

(9 citation statements)

References 171 publications

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“…The interaction between liver disease and gut dysbiosis is a concern in both basic and clinical research [ 24 ]. Recent studies on the NAFLD-related gut microbiota changes have focused primarily on plant compounds, pharmaceutical ingredients or probiotics and prebiotics that may potentially reverse liver steatosis, such as CM3-SII polysaccharide [ 25 ], flavonoids contained in Citri Reticulatae Pericarpium [ 26 ], fucoxanthin [ 27 ], flaxseed [ 28 ], phytosterols [ 29 ], isoquercetin [ 30 ], NUTRIOSE® soluble fiber [ 31 ]. The gut microbiota shows distinct diversity in subjects of reproductive age but is not so different after menopause between males and females [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Tian,

Xie,

Hong

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Tian,

Xie,

Hong

et al. 2024

Heliyon

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“…Flavonoid-7- O -disaccharides are recognized for their diverse biological activities. For example, hesperidin, naringin, diosmin, and neodiosmin have demonstrated various health benefits, including the treatment of alcoholic liver disease, prevention of osteoporosis, osteoarthritis, and diabetes, among other diseases. − Although glycosyltransferases for biosynthesis of flavonoid disaccharides have been reported in many plants, such as Arabidopsis and citrus, inadequate information is available regarding the synthesis of specialized flavone disaccharides, such as neodiosmin.…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Glycosyltransferases Involved in the Biosynthesis of Neodiosmin

Chang,

Fang,

Yao

et al. 2024

J. Agric. Food Chem.

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Glycosylation plays a very important role in plant secondary metabolic modifications. Neodiosmin, identified as diosmetin-7-O-neohesperidoside, not only acts to mitigate bitterness and enhance the flavor of food but also serves as a pivotal metabolite that reinforces plant immunity. Investigating its biosynthetic pathway in plants is crucial for optimizing fruit quality and fortifying plant immune responses. In this study, through analysis of transcriptomic data from Astilbe chinensis, we identified two novel uridine diphosphate (UDP)-glycosyltransferases (UGTs): Ach14791 (AcUGT73C18), responsible for flavonoid 7-Oglycosylation and Ach15849 (AcUGT79B37), involved in flavonoid-7-O-glucoside-2″-O-rhamnosylation. By delving into enzymatic properties and catalytic promiscuity, we developed a biosynthesis route of neodiosmin by establishing a one-pot enzyme-catalyzed cascade reaction. Simultaneously, lonicerin and rhoifolin were also successfully synthesized using the same one-pot dual-enzyme catalytic reaction. Taken together, our findings not only identified two novel UGTs involved in neodiosmin biosynthesis but also provided important biocatalytic components for the microorganism-based biosynthesis of flavonoid-7-O-disaccharide compounds.

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“…Because of its antioxidant [2], antitumor [3], antiinflammatory [4], antibacterial, and other biological activities [5], naringin has potential preventive and therapeutic effects on human diseases. For example, naringin is thought to enhance the function of the hepatic antioxidant system as well as the metabolism of hepatotoxic substances [6], improve insulin resistance and glucose uptake by inhibiting enzymes that metabolize carbohydrates [7]. In addition, naringin alleviated LPS-induced intestinal barrier damage by inhibiting inflammatory factors, improving antioxidant function and intestinal tight junctions [8,9].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of the Naringin–Chitooligosaccharide Complex on Lipopolysaccharide-Induced Systematic Inflammatory Response Syndrome Model in Mice

Tang,

Ouyang,

Tan

et al. 2024

Foods

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Naringin is one of the common flavonoids in grapefruit, which has anti-cancer, antioxidant, and anti-inflammatory activities. However, its poor solubility limits its wide application. Therefore, the aim of this study is to investigate the anti-inflammatory effect of naringin combined with chitooligosaccharides with good biocompatibility by constructing a mouse model of systemic inflammatory response syndrome (SIRS). The results showed that the naringin–chitooligosaccharide (NG-COS) complex significantly inhibited lipopolysaccharide (LPS)-induced weight loss, reduced food intake, tissue inflammatory infiltration, and proinflammatory cytokines IL-6, TNF-α, INF-γ, and IL-1β levels. The complex also significantly affected the content of malondialdehyde and the activities of MPO, SOD, and GSH in the liver, spleen, lungs, and serum of mice with systemic inflammation. In addition, NG-COS significantly inhibited the mRNA expression of inflammatory factors in the TLR4/NF-κB signaling pathway. Principal component analysis showed that the complexes could inhibit LPS-induced systemic inflammation in mice, and the effect was significantly better than that of naringin and chitooligosaccharides alone. This study explored the synergistic effects of chitosan and naringin in reducing inflammation and could contribute to the development of novel biomedical interventions.

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Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury

Cited by 21 publications

References 171 publications

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Identification and Characterization of Glycosyltransferases Involved in the Biosynthesis of Neodiosmin

Protective Effect of the Naringin–Chitooligosaccharide Complex on Lipopolysaccharide-Induced Systematic Inflammatory Response Syndrome Model in Mice

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