The addition of artificial pinning centers has led to an impressive increase in the critical current density (Jc) of superconductors, enabling record-breaking all-superconducting magnets and other applications. The Jc of superconductors has reached ~0.2–0.3 Jd, where Jd is the depairing current density, and the numerical factor depends on the pinning optimization. By modifying λ and/or ξ, the penetration depth and coherence length, respectively, we can increase Jd. For (Y0.77Gd0.23)Ba2Cu3Oy ((Y,Gd)123), we can achieve this by controlling the carrier density, which is related to λ and ξ. We can also tune λ and ξ by controlling the chemical pressure in Fe-based superconductors, i.e., BaFe2(As1−xPx)2 films. The variation in λ and ξ leads to an intrinsic improvement in Jc via Jd, allowing extremely high values of Jc of 130 MA/cm2 and 8.0 MA/cm2 at 4.2 K, consistent with an enhancement in Jd of a factor of 2 for both incoherent nanoparticle-doped (Y,Gd)123 coated conductors (CCs) and BaFe2(As1−xPx)2 films, showing that this new material design is useful for achieving high critical current densities in a wide array of superconductors. The remarkably high vortex-pinning force in combination with this thermodynamic and pinning optimization route for the (Y,Gd)123 CCs reached ~3.17 TN/m3 at 4.2 K and 18 T (H||c), the highest values ever reported for any superconductor.