Progress on Applying Carbon Dots for Inhibition of RNA Virus Infection

Kwee, Yaung; Zhou, Yiqun; Fahmi, Mochamad Zakki; Sharon, Madhuri; Kristanti, Alfinda Novi

doi:10.7150/ntno.73918

Cited by 10 publications

(5 citation statements)

References 78 publications

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“…The pyrolysis of curcumin yielded these hydrophilic, positively charged, 1.5 nmsized antiviral fluorescent CCM-C-dots that are very effective against coronavirus models (porcine epidemic diarrhea virus). 93 In 2020, Tong et al found that respiratory syndrome virus (PRRSV) is suppressed by Gly-C-dots produced from glycyrrhizic acid and observed that Gly-C-dots possess a high level of antiviral activity on this specific virus. In conclusion, it was dictated that Gly-C-dot is not an effective preventer of either adsorption or release of PRRSV progeny when effects on viral proliferation were studied, focusing on stages of adsorption, invasion, replication, and release.…”

Section: ■ Methods Of Synthesis Of C-dotsmentioning

confidence: 99%

“…C-dots have demonstrated their ability to be inhibitors on a multisite level against the enteric coronavirus. The pyrolysis of curcumin yielded these hydrophilic, positively charged, 1.5 nm-sized antiviral fluorescent CCM-C-dots that are very effective against coronavirus models (porcine epidemic diarrhea virus) …”

Section: Biological Activity Of C-dotsmentioning

confidence: 99%

“…The pyrolysis of curcumin yielded these hydrophilic, positively charged, 1.5 nm-sized antiviral fluorescent CCM-C-dots that are very effective against coronavirus models (porcine epidemic diarrhea virus). 93 …”

Section: Biological Activity Of C-dotsmentioning

confidence: 99%

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Carbon Dot Based Carbon Nanoparticles as Potent Antimicrobial, Antiviral, and Anticancer Agents

Hussen,

Hasan,

FaqiKhedr

et al. 2024

ACS Omega

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Antimicrobial and anticancer drugs are widely used due to increasing widespread infectious diseases caused by microorganisms such as bacterial, fungal, viral agents, or cancer cells, which are one of the major causes of mortality globally. Nevertheless, several microorganisms developed resistance to antibiotics as a result of genetic changes that have occurred over an extended period. Carbon-based materials, particularly carbon dots (C-dots), are potential candidates for antibacterial and anticancer nanomaterials due to their low toxicity, ease of synthesis and functionalization, high dispersibility in aqueous conditions, and promising biocompatibility. In this Review, the content is divided into four sections. The first section concentrates on C-dot structures, surface functionalization, and morphology. Following that, we summarize C-dot classifications and preparation methods such as arc discharge, laser ablation, electrochemical oxidation, and so on. The antimicrobial applications of C-dots as antibacterial, antifungal, and antiviral agents both in vivo and in vitro are discussed. Finally, we thoroughly examined the anticancer activity displayed by C-dots.

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Section: ■ Methods Of Synthesis Of C-dotsmentioning

confidence: 99%

Section: Biological Activity Of C-dotsmentioning

confidence: 99%

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Carbon Dot Based Carbon Nanoparticles as Potent Antimicrobial, Antiviral, and Anticancer Agents

Hussen,

Hasan,

FaqiKhedr

et al. 2024

ACS Omega

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“…Therefore, discussing the methods of carbon dots synthesis is as important as discussing their applications. Under this circumstance, several studies reported synthetic methods of carbon dots [32][33][34][35][36][37]. Therefore, synthesis methods of carbon dots would not be discussed immensely.…”

Section: Advances In Carbon Dots Synthesismentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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Fluorescent Carbon dots (CDs) derived from biologically active sources have shown enhanced activities compared to their precursors. With their prominent potentiality, these small-sized (<10nm) nanomaterials could be easily synthesized from organic sources either by bottom-up or green approach. Their sources could influence the functional groups present on the CDs surfaces. A crude source of organic molecules has been used to develop fluorescent CDs. In addition, pure organic molecules were also valuable in developing practical CDs. Physiologically responsive interaction of CDs with various cellular receptors is possible due to the robust functionalization on their surface. In this review, we studied various literatures from the past ten years that reported the potential application of carbon dots as alternatives in cancer chemotherapy. The selective cytotoxic nature of some of the CDs towards cancer cell lines suggests the role of surface functional groups towards selective interaction, which results in over-expressed proteins characteristic of cancer cell lines. It could be inferred that cheaply sourced CDs could selectively bind to overexpressed proteins in cancer cells with the ultimate effect of cell death induced by apoptosis. In most cases, CDs-induced apoptosis directly or indirectly follows the mitochondrial pathway. Therefore, these nanosized CDs could serve as alternatives to the current kinds of cancer treatments that are expensive and have numerous side effects.

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“…Once CDs enter the brain, CDs incorporating contrast agents enable magnetic resonance imaging (MRI). In addition, certain CD species were observed to target bones and inhibit both the replication and cell entry of viruses such as human immunodeficiency virus (HIV) and SARS-CoV-2 . Most significantly, the singlet oxygen and ROS generated in the aforementioned photocatalysis have promoted the applications of CDs in photodynamic therapies, which are often accompanied by photothermal therapies. , Compared to the other areas, studies on the surface chemistry of CDs are insufficient.…”

Section: Introductionmentioning

confidence: 99%

Structure–Property–Activity Relationships in Carbon Dots

2022

Self Cite

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Carbon dots (CDs) are one of the most versatile nanomaterials discovered in the 21st century. They possess many properties and thus hold potentials in diverse applications. While an increasing amount of attention has been given to these novel nanoparticles, the broad scientific community is actively engaged in exploring their limits. Recent studies on the fractionalization and assembly of CDs further push the limits beyond just CDs and demonstrate that CDs are both a mixture of heterogeneous fractions and promising building blocks for assembly of large carbon-based materials. With CDs moving forward toward both microscopic and macroscopic levels, a good understanding of the structure−property−activity relationships is essential to forecasting the future of CDs. Hence, in this Perspective, structure−property− activity relationships are highlighted based on the repeatedly verified findings in CDs. In addition, studies on CD fractionalization and assembly are briefly summarized in this Perspective. Eventually, these structure−property−activity relationships and controllability are essential for the development of CDs with desired properties for various applications especially in photochemistry, electrochemistry, nanomedicine, and surface chemistry. In summary, in our opinion, since 2004 until the present, history has witnessed a great development of CDs although there is still some room for more studies. Also, considering many attractive properties, structure−property−activity relationships, and the building block nature of CDs, a variety of carbon-based materials of interest can be constructed from CDs with control. They can help reduce blind trials in the development of carbon-based materials, which is of great significance in materials science, chemistry, and any fields related to the applications.

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Progress on Applying Carbon Dots for Inhibition of RNA Virus Infection

Cited by 10 publications

References 78 publications

Carbon Dot Based Carbon Nanoparticles as Potent Antimicrobial, Antiviral, and Anticancer Agents

Carbon Dot Based Carbon Nanoparticles as Potent Antimicrobial, Antiviral, and Anticancer Agents

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Structure–Property–Activity Relationships in Carbon Dots

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