2016
DOI: 10.1055/s-0036-1588665
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Progress on Chiral NAD(P)H Model Compounds

Abstract: NAD(P)H and NAD + have a significant role in biochemistry, and many NAD(P)H models received particular attention. Research in NADH models mainly focuses on asymmetric reduction and life sciences. Over the past few decades, a particularly large number of new chiral NAD(P)H models have appeared, and there have been significant developments in this area. We summarized advanced research in chiral NAD(P)H models in this paper. These models not only show very good performance in asymmetric reduction, but also have e… Show more

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Cited by 12 publications
(10 citation statements)
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“…[4] Over the last few years,n umerous synthetic examples of the selective incorporation of fluorine-containing groups into organic molecules have been developed. [5][6][7][8][9] Among them, trifluoroethyl aryl ethers have attracted much attention because of the high metabolic stability and significant lipophilicity of the CF 3 CH 2 Og roup. [10,11] As ac onsequence of their various beneficial pharmacological activities,t rifluoroethyl aryl ethers are widely used by the pharmaceutical industry in many drugs and drug candidates.…”
mentioning
confidence: 99%
“…[4] Over the last few years,n umerous synthetic examples of the selective incorporation of fluorine-containing groups into organic molecules have been developed. [5][6][7][8][9] Among them, trifluoroethyl aryl ethers have attracted much attention because of the high metabolic stability and significant lipophilicity of the CF 3 CH 2 Og roup. [10,11] As ac onsequence of their various beneficial pharmacological activities,t rifluoroethyl aryl ethers are widely used by the pharmaceutical industry in many drugs and drug candidates.…”
mentioning
confidence: 99%
“…Pellets were pressed into 0.02‐mm‐thick films at 170°C. The HDPE substrate, polyethylene (PE)–COOH film, and 4′‐(4‐hydroxyphenyl)‐2,2′:6′,2″‐terpyridine (HOPhtpy) were prepared according to the literature.…”
Section: Methodsmentioning
confidence: 99%
“…Preparation of the second building block, that is, the 2-vinylproline derivative 12,w as achieved as shown in Scheme 3b y slightly modifying the synthesis of Bittermann and Gmeiner. [22] First, l-proline (5)w as protected by treatment with chloral [23] and the resulting cyclic N,O-acetal was formylated (lithium diisopropylamide (LDA), HCO 2 Me) to diastereoselectively [24] give the aldehyde 10 in 54 %y ield over two steps. [22] Thec onfiguration of 10 wasa gain secured by X-ray crystallography (Figure 3, left).…”
Section: Synthesismentioning
confidence: 99%