Progress on the Antimicrobial Activity Research of Clove Oil and Eugenol in the Food Antisepsis Field

Hu, Qiao; Zhou, Meifang; Wei, Shuyong

doi:10.1111/1750-3841.14180

Cited by 113 publications

(64 citation statements)

References 58 publications

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“…e inhibition halos induced by S. aromaticum essential oil were higher than eugenol standard. It has been reported that essential oil possesses antimicrobial activity due to the presence of eugenol, which is described as the most important component of cloves, but such activity has also been found to be due to other phenolic compounds [33,34]. Our results make it evident that the biocomplex is responsible for such activity, reinforcing the results of MIC determination.…”

Section: Discussionsupporting

confidence: 85%

GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol

Teles

Silva-Silva

Fernandes

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Syzygium aromaticum has a diversity of biological activities due to the chemical compounds found in its plant products such as total phenolic compounds and flavonoids. The present work describes the chemical analysis and antimicrobial, antioxidant, and antitrypanosomal activity of the essential oil of S. aromaticum. Eugenol (53.23%) as the major compound was verified by gas chromatography-mass spectrometry. S. aromaticum essential oil was more effective against S. aureus (MIC 50 μg/mL) than eugenol (MIC 250 μg/mL). Eugenol presented higher antioxidant activity than S. aromaticum essential oil, with an EC50 of 12.66 and 78.98 µg/mL, respectively. S. aromaticum essential oil and eugenol exhibited Trypanosoma cruzi inhibitory activity, with IC50 of 28.68 ± 1.073 and 31.97 ± 1.061 μg/mL against epimastigotes and IC50 of 64.51 ± 1.658 and 45.73 ± 1.252 μg/mL against intracellular amastigotes, respectively. Both compounds presented low cytotoxicity, with S. aromaticum essential oil displaying 15.5-fold greater selectivity for the parasite than the cells. Nitrite levels in T. cruzi-stimulated cells were reduced by essential oil (47.01%; p = 0.002) and eugenol (48.05%; p = 0.003) treatment. The trypanocidal activity of S. aromaticum essential oil showed that it is reasonable to use it in future research in the search for new therapeutic alternatives for trypanosomiasis.

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Section: Discussionsupporting

confidence: 85%

GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol

Teles

Silva-Silva

Fernandes

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…12,15 Among them, carvacrol (from oregano) and eugenol (from clove bud) are EOs used as antimicrobials. [16][17][18][19] The carvacrol in concentrations between 0.8 and 1.2 wt% presents a content of phenolic groups that acts directly in the cytoplasmic membrane responding against Gram-negative bacteria. 16,17 Eugenol in concentrations between 1 and 5 wt% acts effectively against Salmonella sp.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial films containing hybrid systems aiming at packaging applications

Camani

Torin

Souza

et al. 2020

Polymer International

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A critical issue in active packaging development using essential oils (EOs) is the high concentrations of these to obtain antimicrobial activity in the films. Therefore, this work was carried out to develop nanocomposite films, pursuing a potential minimal EO concentration with antimicrobial effectiveness, which could be applied in packaging. The films were prepared using lowdensity polyethylene (LDPE) containing a hybrid of montmorillonite and essential oil (MMT-EO), using two different EOs, carvacrol and eugenol, with 2 and 6 wt% oil concentration. The films were obtained in three steps. In the first (hybrid production), mixtures of montmorillonite clay with eugenol or carvacrol EOs were prepared. In the second (hybrid incorporation), these hybrids were incorporated into LDPE, obtaining LDPE/MMT-EO nanocomposites. Finally, a thermoforming process prepared the polymeric films. The samples were characterized by XRD and mechanical, contact angle and antimicrobial properties. The XRD results showed higher crystallinity for LDPE/MMT-EO compared to LDPE. The MMT was exfoliated into lamella forms, which could work as a physical barrier, reducing the oil diffusion. Besides, the contact angle results showed an increase in the hydrophilicity with the addition of the hybrids, which improved the antimicrobial action of the film. LDPE/MMT-E3 (1 wt% MMT and 2 wt% eugenol) showed the highest crystallinity, oil diffusivity, and mechanical and antimicrobial properties. These samples presented a reduction of a 2 log count of Staphylococcus aureus. The sum of the structural and antimicrobial properties of the LDPE/MMT-E3 film indicates its potential for food packaging.

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“…Eugenol (Eug) is a botanical spice with a strong clove scent, and is often used as a food preservative (Hu, Zhou, & Wei, 2018;Zhang, Zhang, Xu, & Hu, 2017) and in food packaging (Garrido-Miranda, Rivas, Perez-Rivera, Sanfuentes, & Pena-Farfal, 2018) due to its antibacterial, antifungal, antioxidant and various properties (Prasad, 2013). The eugenol group of compounds include eugenol, isoeugenol, methyl eugenol, methyl isoeugenol, etc.…”

Section: Introductionmentioning

confidence: 99%

Development of a colloidal gold immunoassay for the detection of four eugenol compounds in water

Shen

Liu

et al. 2019

Food and Agricultural Immunology

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A monoclonal antibody (mAb), 2C9, selective for four eugenol compounds, was developed based on the eugenol derivatives (Eug-1). The semi-inhibitory concentrations (IC 50) of this antibody against eugenol, isoeugenol, methyl eugenol, and methyl isoeugenol were 0.043, 0.302, 0.016, and 0.082 μg/mL, respectively, and the detection limits (LOD) were 0.012, 0.070, 0.004 and 0.024 μg/mL. With the exception of isoeugenol, which had cross-reactivity of less than 15%, the cross-reactivity of the other compounds was good, ranging from 52.4% to 269%. In the ic-ELISA recovery test, recovery was between 80% and 94%, indicating that the method was suitable for analysis of eugenol compounds in water. The cutoff values of the immunochromatographic strips for the four compounds in water were 5, 100, 100, and 100 μg/mL, respectively, indicating that the ic-ELISA and immunochromatographic strips we developed can be used to rapidly detect eugenol compounds in water.

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Progress on the Antimicrobial Activity Research of Clove Oil and Eugenol in the Food Antisepsis Field

Cited by 113 publications

References 58 publications

GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol

GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol

Antimicrobial films containing hybrid systems aiming at packaging applications

Development of a colloidal gold immunoassay for the detection of four eugenol compounds in water

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