Progress on the reaction-based methods for detection of endogenous hydrogen sulfide

Halogen bonding and chalcogen bonding mediated sensing

“…101 Formed upon dissolution of the toxic H 2 S gas, the sensing of HS À remains a formidable challenge, in spite of its increasing relevance in environmental and medicinal settings. 102,103 Thus far, the vast majority of HS À sensors are irreversible optical chemodosimeters, 104,105 while host-guest recognition of this anion remains largely underexplored. [106][107][108] Receptor 6.XB not only presents a rare example of a reversible supramolecular HS À host but is capable of selective sensing of this analyte in water.…”

Construction of a coumarin-based fluorescent probe for accurately visualizing hydrogen sulfide in live cells and zebrafish

“…Based on chemical properties such as reducibility, nucleophilicity and metal coordination, researchers have developed a series of H 2 S uorescent probes. [17][18][19][20][21][22][23][24][25] However, some of the reported probes have the disadvantages of environmental sensitivity, long reaction time, high detection limit, and the need for large amounts of organic solvents as co-solvents. It is still necessary to develop new smallmolecule uorescent probes for H 2 S that can overcome these limitations.…”

A ruthenium nitrosyl complex-based highly selective colorimetric sensor for biological H2S and H2S–NO cross-talk regulated release of NO

“…8,17 A recent report also suggests that H 2 S increases the rate of NO release from small organic NO donors owing to the interaction between H 2 S and NO. 18 Several methods such as (a) H 2 S-specific reduction of azides and nitro groups, 19 (b) H 2 S-specific thiolysis, (c) H 2 Sspecific nucleophilic reactions, 20 (d) H 2 S-specific cleavage of the disulfide bond, and (e) the H 2 S-induced metal displacement approach (MDA) and the metal indicator displacement approach (MIDA) 21,22 are known for the design of H 2 S chemical and biosensors. 23,24 However, the interaction of NO and H 2 S has not been explored for the detection of H 2 S. The use of a ruthenium nitrosyl complex for the sensing of H 2 S using H 2 S-NO cross-talk was not known before.…”