Progress risk assessment of oral premalignant lesions with saliva miRNA analysis

Yang, Ya; Li, Yue-xiu; Yang, Xi; Jiang, Long; Zhou, Zuo-jun; Zhu, Yaqin

doi:10.1186/1471-2407-13-129

Cited by 71 publications

(57 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yang et al identified 25 miRNAs differentially expressed between progressive and non-progressive low-grade oral dysplasia leucoplakia [150]. They went on to identify 5 of those to be detectably differentially expressed in the saliva of patients with progressive low-grade dysplasia compared to non-progressive.…”

Section: Precancermentioning

confidence: 98%

MicroRNAs and head and neck cancer: Reviewing the first decade of research

Sethi¹,

Wright²,

Wood³

et al. 2014

European Journal of Cancer

View full text Add to dashboard Cite

Section: Precancermentioning

confidence: 98%

MicroRNAs and head and neck cancer: Reviewing the first decade of research

Sethi¹,

Wright²,

Wood³

et al. 2014

European Journal of Cancer

View full text Add to dashboard Cite

“…Furthermore, the roles of miRNAs have been described in several diseases, including cancers [70,71,72,73], coronary diseases [74,75,76], autoimmune diseases [77,78,79] or viral infections such as viral hepatitis [80,81,82,83]. miRNAs predominantly exist intracellularly, however, it is possible to find miRNAs in extracellular environments such as in serum, plasma, semen, cerebrospinal fluid and urine [84,85,86,87,88,89,90,91]. Two hypotheses are proposed to explain the origin of circulatory miRNAs.…”

Section: Circulatory Mirnas As Biomarkers Of Diseasementioning

confidence: 99%

Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease

Calvopina

Coleman

Lewindon

et al. 2016

IJMS

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are short non-coding RNAs involved in biological and pathological processes of every cell type, including liver cells. Transcribed from specific genes, miRNA precursors are processed in the cytoplasm into mature miRNAs and as part of the RNA-induced silencing complex (RISC) complex binds to messenger RNA (mRNA) by imperfect complementarity. This leads to the regulation of gene expression at a post-transcriptional level. The function of a number of different miRNAs in fibrogenesis associated with the progression of chronic liver disease has recently been elucidated. Furthermore, miRNAs have been shown to be both disease-and tissue-specific and are stable in the circulation, which has led to increasing investigation on their utility as biomarkers for the diagnosis of chronic liver diseases, including those in children. Here, we review the current knowledge on the biogenesis of microRNA, the mechanisms of translational repression and the use of miRNA as circulatory biomarkers in chronic paediatric liver diseases including cystic fibrosis associated liver disease, biliary atresia and viral hepatitis B.

show abstract

“…In 2013, Yang et al . [72] reported firstly the use of microRNA microarray to profile low-grade dysplasia (LGD) oral premalignant lesions (OPLs) from progressing and non-progressing LGD OPLs, in order to explore the possible microRNAs, which later could lead the progression into high-grade dysplasia (HGD) or OSCC. They identified 25 miRNAs differentially expressed between progressive and non-progressive LGD leukoplakias.…”

Section: Salivary Non-coding Rnas Associated With (Patho) Physiolomentioning

confidence: 99%

Salivary Extracellular Noncoding RNA: Emerging Biomarkers for Molecular Diagnostics

Wong

2015

Clinical Therapeutics

View full text Add to dashboard Cite

Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, nourished by body’s vasculature. While many circulatory molecules (DNA, RNA and proteins) could also be present in saliva, saliva harbors unique molecular constituents that can be discriminatory for oral and systemic disease screening and detection. Many studies have reported that salivary constituents can discriminate oral diseases (oral cancer and Sjögren’s Syndrome) and also systemic diseases (lung cancer, breast cancer, pancreatic cancer and ovarian cancer). Non-coding RNAs (ncRNAs) are emerging new regulators of diverse biological functions, playing important roles in oncogenesis and tumor progression. Indeed, the short size of these molecules makes them very stable in different body fluids such as urine, blood and saliva, being not as susceptible as mRNAs to degradation by RNases. Here, we reviewed the current status and clinical implications of the ncRNAs present in human saliva for translational applications and basic biological research. The development of non-invasive salivary test (based on ncRNAs profiles) for disease detection, could have impactful applications into the clinical context with a translational significance as emerging molecular biomarkers for non-invasively disease detection, not only by reducing the cost to the healthcare system, but also benefitting patients.

show abstract

Progress risk assessment of oral premalignant lesions with saliva miRNA analysis

Cited by 71 publications

References 22 publications

MicroRNAs and head and neck cancer: Reviewing the first decade of research

MicroRNAs and head and neck cancer: Reviewing the first decade of research

Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease

Salivary Extracellular Noncoding RNA: Emerging Biomarkers for Molecular Diagnostics

Contact Info

Product

Resources

About