Progress toward finding the perfect match: hydrogels for treatment of central nervous system injury

Hlavac, Nora; Kasper, Mary; Schmidt, Christine E.

doi:10.1016/j.mtadv.2019.100039

Cited by 30 publications

(37 citation statements)

References 142 publications

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“…Makhijaa et al reported that the stiffness, strain, topography, and spatial constraints of scaffolds play a key role in promoting the myelination of OPCs cells [ 48 ]. Hlavac et al claimed that hydrogel scaffolds are suitable for nerve cell proliferation, differentiation, and repair [ 49 ]. In this study, PLLA scaffolds coated with hydrophilic material have played a very excellent role in promoting myelination.…”

Section: Resultsmentioning

confidence: 99%

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination

et al. 2021

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Myelin sheaths are essential in maintaining the integrity of axons. Development of the platform for in vitro myelination would be especially useful for demyelinating disease modeling and drug screening. In this study, a fiber scaffold with a core–shell structure was prepared in one step by the coaxial electrospinning method. A high-molecular-weight polymer poly-L-lactic acid (PLLA) was used as the core, while the shell was a natural polymer material such as hyaluronic acid (HA), sodium alginate (SA), or chitosan (CS). The morphology, differential scanning calorimetry (DSC), Fourier transform infrared spectra (FTIR), contact angle, viability assay, and in vitro myelination by oligodendrocytes were characterized. The results showed that such fibers are bead-free and continuous, with an average size from 294 ± 53 to 390 ± 54 nm. The DSC and FTIR curves indicated no changes in the phase state of coaxial brackets. Hyaluronic acid/PLLA coaxial fibers had the minimum contact angle (53.1° ± 0.24°). Myelin sheaths were wrapped around a coaxial electrospun scaffold modified with water-soluble materials after a 14-day incubation. All results suggest that such a scaffold prepared by coaxial electrospinning potentially provides a novel platform for oligodendrocyte myelination.

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Section: Resultsmentioning

confidence: 99%

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination

et al. 2021

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“…Combination of HA with synthetic peptides in particular RGD and IKVAV potentially supports differentiation of neural progenitor cells (NPC) into oligodendrocytes and synapse-forming neurons [ 294 ]. Hydrogels have been employed to recapitulate and improve regeneration and functions of CNS [ 295 ]. Injectable self-assembling peptide-based hydrogel (SAPH) used directly on the rat brain after traumatic brain injury significantly triggers VEGF-receptor 2 and thereby enhances angiogenic effect and new blood vessel formation.…”

Section: Chronic Inflammation-associated Diseases and Therapiesmentioning

confidence: 99%

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

et al. 2021

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Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. Under a normal physiological framework, inflammation is necessary for the systematic immunity including tissue repair and regeneration as well as returning to homeostasis. Inflammatory cellular response and metabolic mechanisms play key roles in the well-orchestrated tissue regeneration. If this response is dysregulated, it becomes chronic, which in turn causes progressive fibrosis, improper repair, and autoimmune disorders, ultimately leading to organ failure and death. Therefore, understanding of the complex inflammatory multiple player responses and their cellular metabolisms facilitates the latest insights and brings novel therapeutic methods for early diseases and modern health challenges. This review discusses the recent advances in molecular interactions of immune cells, controlled shift of pro- to anti-inflammation, reparative inflammatory metabolisms in tissue regeneration, controlling of an unfavorable microenvironment, dysregulated inflammatory diseases, and emerging therapeutic strategies including the use of biomaterials, which expand therapeutic views and briefly denote important gaps that are still prevailing.

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“…27 Treatments in CNS injuries have focused on restoring secondary injuries and providing structural support and extracellular cues for cell ingrowth and tissue recovery. 28 The use of injectable hydrogel has become an appealing treatment option due to the capability in providing mechanical support as well as flexibility in shapes and material choices. In SCI, the lesion is further complicated by glial scars formed by reactive astrocytes, leading to further inhibitory barrier that prevents recovery.…”

Section: Stroke and Sci Pathologymentioning

confidence: 99%

Injectable hydrogels in stroke and spinal cord injury treatment: a review on hydrogel materials, cell–matrix interactions and glial involvement

2021

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Progress toward finding the perfect match: hydrogels for treatment of central nervous system injury

Cited by 30 publications

References 142 publications

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Injectable hydrogels in stroke and spinal cord injury treatment: a review on hydrogel materials, cell–matrix interactions and glial involvement

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