Progress With the All of Us Research Program

Ramirez, Andrea H.; Gebo, Kelly A.; Harris, Paul A.

doi:10.1001/jama.2021.7702

Cited by 44 publications

(37 citation statements)

References 4 publications

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“… 39 The All of Us project also provides a data explorer to view data availability across various data types including survey and digital health data. 40 These approaches rely on standard coding systems only and lack the flexibility of the ontology-driven i2b2 queries. The Observational Health Data Science Initiative provides a number of analytic tools for study cohort feasibility and generation focused primarily on EHR data with some extensions into NLP and other data.…”

Section: Discussionmentioning

confidence: 99%

The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics

Castro

Gainer

Wattanasin

et al. 2021

Journal of the American Medical Informatics Association

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Objective Integrating and harmonizing disparate patient data sources into one consolidated data portal enables researchers to conduct analysis efficiently and effectively. Materials and Methods We describe an implementation of Informatics for Integrating Biology and the Bedside (i2b2) to create the Mass General Brigham (MGB) Biobank Portal data repository. The repository integrates data from primary and curated data sources and is updated weekly. The data are made readily available to investigators in a data portal where they can easily construct and export customized datasets for analysis. Results As of July 2021, there are 125 645 consented patients enrolled in the MGB Biobank. 88 527 (70.5%) have a biospecimen, 55 121 (43.9%) have completed the health information survey, 43 552 (34.7%) have genomic data and 124 760 (99.3%) have EHR data. Twenty machine learning computed phenotypes are calculated on a weekly basis. There are currently 1220 active investigators who have run 58 793 patient queries and exported 10 257 analysis files. Discussion The Biobank Portal allows noninformatics researchers to conduct study feasibility by querying across many data sources and then extract data that are most useful to them for clinical studies. While institutions require substantial informatics resources to establish and maintain integrated data repositories, they yield significant research value to a wide range of investigators. Conclusion The Biobank Portal and other patient data portals that integrate complex and simple datasets enable diverse research use cases. i2b2 tools to implement these registries and make the data interoperable are open source and freely available.

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Section: Discussionmentioning

confidence: 99%

The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics

Castro

Gainer

Wattanasin

et al. 2021

Journal of the American Medical Informatics Association

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“…The transparency, diversity, and inclusion of the AllofUsRP provide researchers with a unique opportunity to investigate the potential roles that the built environment might play on mental and physical health 23 . AllOfUsRP shares the data assets collected from the participants in a common cloud environment, the All of Us Researcher Workbench 22 . Qualified researchers have access to the dataset and can retrieve and analyze the data through web-based tools and interactive cloud-based computing environments 17 .…”

Section: Methodsmentioning

confidence: 99%

“…AllofUsRP aims to recruit adults (18 years and older) who live in the United States from all backgrounds. To date, the project has enrolled over 300,000 participants, which are from diversified backgrounds (e.g., ethnicities, social behaviors, geographic locations, medical conditions) and represent their community in research studies 22 . The transparency, diversity, and inclusion of the AllofUsRP provide researchers with a unique opportunity to investigate the potential roles that the built environment might play on mental and physical health 23 .…”

Section: Cope Survey Data In All Of Us Research Program and Preproces...mentioning

confidence: 99%

Built environment’s impact on COVID-19 transmission and mental health revealed by COVID-19 Participant Experience data from the All of Us Research Program

Luo

Baldwin

Jiang

et al. 2022

Preprint

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Objectives: The coronavirus disease 2019 (COVID-19) pandemic has led to millions of deaths. Effectively cutting the transmission of COVID-19 is essential to reduce the impact. Previous studies have observed the potential relationship between the built environment and COVID-19 transmission, however, to date, stringent studies investigating these relationships at the individual level are still insufficient. Here, we aim to examine the relationship between household types and COVID-19 infection (or mental health) during the early stages of the pandemic by using the All of Us Research Program COVID-19 Participant Experience (COPE) Survey data. Design: Based on 62,664 participants' responses to COPE from May to July 2020, we matched the cases of self-reported COVID-19 status, anxiety, or stress, with controls of the same race, sex, age group, and survey version. We conducted multiple logistic regressions between one of the outcomes and household type under the adjustment of other related covariates, such as ethnicity, age, social distancing behavior, and house occupancy. Results: Household type with a shared component was significantly associated with COVID-19 infection (OR=1.19, 95% CI 1.1 to 1.3; p=2x10-4), anxiety (OR=1.26, 95% CI 1.1 to 1.4; p=1.1x10-6), and stress (OR=1.29, 95% CI 1.2 to 1.4, p=4.3x10-10) as compared to free-standing houses after adjusted for the abovementioned confounding factors. Further, frequent nonessential shopping or outings, another indicator of built environment, was also associated with COVID-19 infection (OR=1.36, 95% CI 1.1 to 1.8; p=0.02), but not associated with elevated mental health conditions. Conclusion: Our study demonstrated that the built environment of houses with a shared component tends to increase the risk of COVID-19 transmission, which consequently led to more anxiety and stress for their dwellers. It also suggested the necessity to improve the quality of the built environment through planning, design, and management toward a more resilient society in coping with future pandemics.

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“…Individual differences in lifestyle, environment, and biology will be analyzed in the hopes of building a diverse database that will uncover paths toward delivering precision and personalized medicine [16]. Thus far, they have already recruited 386,000 adults, with 80% from populations previously underrepresented in biomedical research [31].…”

Section: Current Strategies 21 Research-based Ventures (Voluntary Participants)mentioning

confidence: 99%

Profit versus Quality: The Enigma of Scientific Wellness

Carbonara

MacNeil

O’Leary

et al. 2022

JPM

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The “best of both worlds” is not often the case when it comes to implementing new health models, particularly in community settings. It is often a struggle between choosing or balancing between two components: depth of research or financial profit. This has become even more apparent with the recent shift to move away from a traditionally reactive model of medicine toward a predictive/preventative one. This has given rise to many new concepts and approaches with a variety of often overlapping aims. The purpose of this perspective is to highlight the pros and cons of the numerous ventures already implementing new concepts, to varying degrees, in community settings of quite differing scales—some successful and some falling short. Scientific wellness is a complex, multifaceted concept that requires integrated experimental/analytical designs that demand both high-quality research/healthcare and significant funding. We currently see the more likely long-term success of those ventures in which any profit is largely reinvested into research efforts and health/healthspan is the primary focus.

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Progress With the All of Us Research Program

Cited by 44 publications

References 4 publications

The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics

The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics

Built environment’s impact on COVID-19 transmission and mental health revealed by COVID-19 Participant Experience data from the All of Us Research Program

Profit versus Quality: The Enigma of Scientific Wellness

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