Progression of nonmotor symptoms in subgroups of patients with non-dopamine-deficient Parkinsonism

Taylor, Stuart P.; Gafton, Joseph; Shah, Bina; Pagano, Gennaro; Brooks, David J.; Pavese, Nicola

doi:10.1002/mds.26456

Cited by 24 publications

(13 citation statements)

References 26 publications

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“…For example, the investigators found that 78% of SWEDD participants, 74% of PD participants, and 86% of healthy controls screened positive for depression using an accepted cutoff of ≥5 on the GDS . These results are not consistent with other published analyses of the Parkinson's Progression Markers Initiative (PPMI) data (Table ); Weintraub and colleagues found that 14% of PD participants and 7% of healthy controls screened positive for depression using the same cutoff . The possibility of scoring errors may be increased with these measures given the requirement of reverse scoring for some items.…”

Section: Comparison Of Ppmi Data Analysesmentioning

confidence: 85%

The prevalence of nonmotor symptoms among SWEDD patients

Schneider

Richard

2016

Movement Disorders

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Section: Comparison Of Ppmi Data Analysesmentioning

confidence: 85%

The prevalence of nonmotor symptoms among SWEDD patients

Schneider

Richard

2016

Movement Disorders

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“…SPECT and PET molecular imaging techniques have been employed to investigate the role of dopaminergic dysfunction in the pathophysiology of iRLS, by imaging post-synaptic D 2 receptor binding, and presynaptic DAT ( 118 ). However, few studies have aimed to characterize the underlying mechanisms of RLS in PD cohorts specifically.…”

Section: Restless Leg Syndromementioning

confidence: 99%

Neuroimaging of Sleep Disturbances in Movement Disorders

et al. 2018

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Sleep dysfunction is recognized as a distinct clinical manifestation in movement disorders, often reported early on in the disease course. Excessive daytime sleepiness, rapid eye movement sleep behavior disorder and restless leg syndrome, amidst several others, are common sleep disturbances that often result in significant morbidity. In this article, we review the spectrum of sleep abnormalities across atypical Parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), as well as Parkinson's disease (PD) and Huntington's disease (HD). We also explore the current concepts on the neurobiological underpinnings of sleep disorders, including the role of dopaminergic and non-dopaminergic pathways, by evaluating the molecular, structural and functional neuroimaging evidence based on several novel techniques including magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Based on the current state of research, we suggest that neuroimaging is an invaluable tool for assessing structural and functional correlates of sleep disturbances, harboring the ability to shed light on the sleep problems attached to the limited treatment options available today. As our understanding of the pathophysiology of sleep and wake disruption heightens, novel therapeutic approaches are certain to transpire.

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“…Another postural tremor can be essential tremor, and there is an increased incidence of PD in patients with essential tremor. It also can be dystonic tremor, and this might even look similar to classic tremor and has been suggested that the scans without evidence of dopamine deficiency patients have dystonic tremor (Taylor et al, 2016). Additionally, a patient can have an exaggerated physiological tremor.…”

Section: 1tremormentioning

confidence: 99%