Progression of vascular calcifications is associated with greater bone loss and increased bone fractures

Naves, Manuel; Rodríguez‐García, Minerva; Díaz-López, J. B.; Gómez‐Alonso, Carlos; Cannata-Andía, Jorge B.

doi:10.1007/s00198-007-0539-1

Cited by 183 publications

(147 citation statements)

References 30 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…BMD was related to baseline AAC in women, but this was due to older women having lower BMD values and higher AAC values than younger women, consistent with some (26,27) but not all previous studies. (28)(29)(30)(31)(32) Supporting this finding was the fact that baseline AAC did not predict subsequent changes in BMD over time, except at the lumbar spine, where the overlying aortic calcification may contribute to the measured BMD. Baseline AAC also was not associated with incident fractures after adjustment for covariates, again consistent with some (34) but not all studies.…”

Section: Discussionmentioning

confidence: 95%

“…Baseline AAC also was not associated with incident fractures after adjustment for covariates, again consistent with some (34) but not all studies. (31)(32)(33) There are several limitations to our study. Participants all were seen at one center, were healthy volunteers with low cardiovascular risk, and mainly were of European descent (>90%).…”

Section: Discussionmentioning

confidence: 98%

“…However, in some studies, this relationship did not persist after adjusting for age or other covariates, (26,27) whereas in others, such adjustments did not explain the association. (28)(29)(30)(31)(32) Similarly, AAC is an independent predictor of fractures in some (31)(32)(33) but not all studies. (34) Coronary artery calcification (CAC), another estab-lished risk factor for cardiovascular disease, (35) also has been associated with low BMD.…”

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Relationships between vascular calcification, calcium metabolism, bone density, and fractures

Wang

Bolland

Pelt

et al. 2010

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Factors involved with calcium metabolism, such as serum calcium and phosphate and calcium intake, have been associated with vascular disease in different populations. We investigated whether this association is mediated via increased vascular calcification by assessing relationships between these factors and abdominal aortic calcification (AAC) and coronary artery calcification (CAC). A total of 1471 healthy postmenopausal women participated in a 5-year randomized, placebo-controlled trial of calcium 1 g/day, and 323 healthy middle-aged and older men participated in a 2-year randomized, placebo-controlled trial of calcium 600 or 1200 mg/day. AAC was assessed on vertebral morphometric images at baseline and follow-up. Based on computed tomography, 163 men had CAC assessed, on average, 1.5 years after study completion. In elderly women, AAC was positively related to serum calcium (p < .001), phosphate (p ¼ .04), and the calcium-phosphate product (p ¼ .003), but changes in AAC over time and incidence of cardiovascular events were not related to these variables. In middle-aged men, AAC and CAC were not consistently related to these variables. Neither dietary calcium intake nor calcium supplementation was associated with changes in the prevalence of AAC over time, and calcium supplementation also was not related to CAC scores in men. After adjusting for age, AAC was not associated with low bone mineral density (BMD) at baseline, changes in BMD over time, or fracture incidence. CAC also was not related to baseline BMD. In summary, serum calcium and phosphate are associated with AAC in older women, but dietary calcium intake and calcium supplementation were not associated with changes in AAC over 2 to 5 years. ß

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Relationships between vascular calcification, calcium metabolism, bone density, and fractures

Wang

Bolland

Pelt

et al. 2010

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…Faster progression of AAC was associated with faster bone loss at the hip in older women, 1 at the lumbar spine (but not femoral neck), 3 at the spine in postmenopausal women, 7 at the metacarpal in women followed up across the menopause, 18 and at the metacarpal in women, but not men 19 ( Figure 1 ). Hypertension was associated with faster bone loss in elderly white women.…”

Section: Association Between Cardiovascular Diseases and Osteoporosismentioning

confidence: 98%

“…Severe abdominal aortic calcification (AAC) was associated with lower BMD at the spine and hip in older women, 1 at the hip and whole body (but not spine) in older women (but not men), 2 at the lumbar spine (but not femoral neck) in a cohort of men and women, 3 at the femoral neck in women 4 and at whole body and distal forearm (but not at the spine or hip) in older men. 5 Severe AAC was associated with lower trabecular volumetric BMD at the spine in postmenopausal women, 6 in peri-and postmenopausal black and white women, 7 and in men and women aged у 45 years.…”

Section: Association Between Cardiovascular Diseases and Bone Mineralmentioning

confidence: 99%

Association between cardiovascular diseases and osteoporosis—reappraisal

Szulc

2012

BoneKEy Reports

View full text Add to dashboard Cite

Many studies published over the past 20 years show a significant positive association between cardiovascular diseases (CVD) and osteoporosis. This association is important because it concerns two major public health problems. The investigation of shared biomarkers (clinical, radiological, biochemical) may improve identification of subjects at high risk of both diseases. The investigation of shared pathophysiological mechanisms may help to understand the pathophysiology of these diseases and to establish new treatments that could be efficient in both diseases. Below, I have tried to analyze various groups of clinical studies to better understand the association between osteoporosis and CVD as well as discrepancies between the studies. My review is focused on the epidemiological studies of the general population, and I have not analyzed the association between bone and CVD in chronic renal failure. Association between Cardiovascular Diseases and Bone Mineral DensitySeveral studies showed that CVD and arterial calcification are associated with decreased bone mineral density (BMD), although findings vary according to skeletal site and gender. Severe abdominal aortic calcification (AAC) was associated with lower BMD at the spine and hip in older women, 1 at the hip and whole body (but not spine) in older women (but not men), 2 at the lumbar spine (but not femoral neck) in a cohort of men and women, 3 at the femoral neck in women 4 and at whole body and distal forearm (but not at the spine or hip) in older men. 5 Severe AAC was associated with lower trabecular volumetric BMD at the spine in postmenopausal women, 6 in peri-and postmenopausal black and white women, 7 and in men and women aged у 45 years. 8 In a group of siblings concordant for type 2 diabetes, severity of the coronary and aortic calcification was correlated negatively with spine volumetric BMD. 9 In other studies, the association between AAC severity and BMD was weak or non-significant. 10 -13 Limited data also suggest a weak but significant association between severe peripheral arterial disease (PAD) and lower BMD at the hip. 14 -16 Elevated diastolic (but not systolic) blood pressure was associated with lower BMD at the total body, trochanter and Ward ' s triangle in a small group of 47 men aged 24 to 77 years. 17 REVIEW Association between cardiovascular diseases and osteoporosis -reappraisal Pawel SzulcINSERM UMR 1033, Universit é de Lyon, H ô pital Edouard Herriot , Lyon , France .Positive association between cardiovascular diseases and osteoporosis is important because it concerns two major public health problems. Men and women with cardiovascular diseases (including severe abdominal aortic calcification (AAC) and peripheral arterial disease) tend to have lower areal and volumetric bone mineral density (BMD) as well as faster bone loss, although findings vary according to skeletal site. On one hand, severe forms of cardiovascular diseases (heart failure, myocardial infarction, hypertension, severe AAC) are associated with higher risk of osteop...

show abstract

The Calcified Vasculature in Chronic Kidney Disease Secretes Factors that Inhibit Bone Mineralization

et al. 2022

View full text Add to dashboard Cite

Vascular calcification and bone disorder progress simultaneously in chronic kidney disease (CKD). Still, how the complex pathological mechanisms are linked is only sparsely understood. Up to now, the focus has been on the disturbed bone metabolism in developing vascular calcification. However, our group has recently demonstrated that vascular calcification has negative effects on bone formation and mineralization as shown in the bone of normal recipient rats transplanted with the calcified aorta from CKD rats. In the present in vitro study, the hypothesis of a direct crosstalk between the vasculature and bone was examined. Calcified aortas from 5/6 nephrectomized rats and normal aortas from control rats were excised and incubated ex vivo. The calcified aorta secreted large amounts of sclerostin, dickkopf‐1 (Dkk1), and activin A. Both normal and calcified aortas secreted frizzle‐related protein 4 (SFRP4). Aorta rings were co‐incubated with the osteoblast‐like cell line UMR‐106. The calcified aorta strongly inhibited calcium crystal formation in UMR‐106 cells, together with a significant upregulation of the mineralization inhibitors osteopontin and progressive ankylosis protein homolog (ANKH). The strong stimulation of osteopontin was blocked by lithium chloride, indicating involvement of Wnt/β‐catenin signaling. The present in vitro study shows detrimental effects of the calcified aorta on bone cell mineralization. These findings support the hypothesis of an active role of the calcified vasculature in the systemic CKD–mineral and bone disorder (CKD‐MBD), resulting in a pathological vascular–bone tissue crosstalk. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

show abstract

Progression of vascular calcifications is associated with greater bone loss and increased bone fractures

Abstract: Aortic calcifications at baseline were positively associated with osteoporotic fractures. The progression of aortic calcifications was also positively associated with the rate of decline in BMD at lumbar spine.

Cited by 183 publications

References 30 publications

Relationships between vascular calcification, calcium metabolism, bone density, and fractures

Relationships between vascular calcification, calcium metabolism, bone density, and fractures

Association between cardiovascular diseases and osteoporosis—reappraisal

The Calcified Vasculature in Chronic Kidney Disease Secretes Factors that Inhibit Bone Mineralization

Contact Info

Product

Resources

About