Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure

Chau, Kevin F.; Springel, Mark W.; Broadbelt, Kevin G.; Park, Hye-Yeon; Topal, Salih; Lun, Melody P.; Mullan, Hillary; Maynard, Thomas M.; Steen, Hanno; LaMantia, Anthony‐Samuel; Lehtinen, Maria K.

doi:10.1016/j.devcel.2015.11.015

Cited by 85 publications

(95 citation statements)

References 74 publications

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“…Shh in the cerebrospinal fluid (CSF) is also a potential source of Shh throughout corticogenesis to influence the behavior of neural stem/progenitor cells lining the lateral ventricles. Indeed, expression of Shh mRNA is detectable in the choroid plexus of the lateral ventricle [21] and Shh has been detected in telencephalic CSF [22, 23]. Other potential sources of Shh are epithelial cells and the developing vascular system, which release Shh-containing microvesicles [24–26].…”

Section: Sources Of Shh Ligands and Expression Patterns Of Pathway Gementioning

confidence: 99%

Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development

Yabut

Pleasure

2018

BPL

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The mammalian neocortex is composed of a diverse population of neuronal and glial cells that are crucial for cognition and consciousness. Orchestration of molecular events that lead to the production of distinct cell lineages is now a major research focus. Recent studies in mammalian animal models reveal that Sonic Hedgehog (Shh) signaling plays crucial roles in this process. In this review, we will evaluate these studies and provide insights on how Shh signaling specifically influence cortical development, beyond its established roles in telencephalic patterning, by specifically focusing on its impact on cells derived from the cortical radial glial (RG) cells. We will also assess how these findings further advance our knowledge of neurological diseases and discuss potential roles of targeting Shh signaling in therapies.

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Section: Sources Of Shh Ligands and Expression Patterns Of Pathway Gementioning

confidence: 99%

Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development

Yabut

Pleasure

2018

BPL

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“…Factors within the embryonic CSF, including sonic hedgehog and choroid plexus-derived insulin-like growth factor 2, promote the proliferation of neural progenitors [59,78,90,170]. The CSF effect is optimal when age-matched CSF and tissue are combined, highlighting the dynamic nature of both the choroid plexus/CSF axis and of the intrinsic state of the responding cells [18,78]. Factors in the blood are also transported across the BCSFB.…”

Section: Embryonic and Postnatal Developmentmentioning

confidence: 99%

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

et al. 2018

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The barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the choroid plexuses. At the interface between two circulating fluids, these richly vascularized veil-like structures display a peculiar morphology explained by their developmental origin, and fulfill several functions essential for CNS homeostasis. They form a neuroprotective barrier preventing the accumulation of noxious compounds into the CSF and brain, and secrete CSF, which participates in the maintenance of a stable CNS internal environment. The CSF circulation plays an important role in volume transmission within the developing and adult brain, and CSF compartments are key to the immune surveillance of the CNS. In these contexts, the choroid plexuses are an important source of biologically active molecules involved in brain development, stem cell proliferation and differentiation, and brain repair. By sensing both physiological changes in brain homeostasis and peripheral or central insults such as inflammation, they also act as sentinels for the CNS. Finally, their role in the control of immune cell traffic between the blood and the CSF confers on the choroid plexuses a function in neuroimmune regulation and implicates them in neuroinflammation. The choroid plexuses, therefore, deserve more attention while investigating the pathophysiology of CNS diseases and related comorbidities.

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“…In the kidney, it also acts as a mechanosensor that detects shear stress, leading to the downregulation of the mTOR pathway necessary for the proper control of cell size (Boehlke et al, 2010;Orhon et al, 2016). The cerebrospinal fluid secreted by the choroid plexus provides diffusible signals that are essential for the early development of RGC Chau et al, 2015;Higginbotham et al, 2013). The apical localization of the primary cilium is thus optimal for detecting chemo-or mechano-sensory signals from the CSF, and thus participates in brain morphogenesis by regulating RGC physiology (Lehtinen and Walsh, 2011).…”

Section: Introductionmentioning

confidence: 99%

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

Foerster¹,

Daclin²,

Shihavuddin³

et al. 2017

Journal of Cell Science

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Radial glial cells (RCGs) are self-renewing progenitor cells that give rise to neurons and glia during embryonic development. Throughout neurogenesis, these cells contact the cerebral ventricles and bear a primary cilium. Although the role of the primary cilium in embryonic patterning has been studied, its role in brain ventricular morphogenesis is poorly characterized. Using conditional mutants, we show that the primary cilia of radial glia determine the size of the surface of their ventricular apical domain through regulation of the mTORC1 pathway. In cilium-less mutants, the orientation of the mitotic spindle in radial glia is also significantly perturbed and associated with an increased number of basal progenitors. The enlarged apical domain of RGCs leads to dilatation of the brain ventricles during late embryonic stages (ventriculomegaly), which initiates hydrocephalus during postnatal stages. These phenotypes can all be significantly rescued by treatment with the mTORC1 inhibitor rapamycin. These results suggest that primary cilia regulate ventricle morphogenesis by acting as a brake on the mTORC1 pathway. This opens new avenues for the diagnosis and treatment of hydrocephalus.

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Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure

Cited by 85 publications

References 74 publications

Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development

Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

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