Progressive effects of silver nanoparticles on hormonal regulation of reproduction in male rats

Dziendzikowska, Katarzyna; Krawczyńska, Agata; Oczkowski, Michał; Królikowski, Tomasz; Brzóska, Kamil; Lankoff, Anna; Dziendzikowski, Michał; Stępkowski, Tomasz M.; Kruszewski, Marcin; Gromadzka-Ostrowska, Joanna

doi:10.1016/j.taap.2016.10.013

Cited by 40 publications

(20 citation statements)

References 60 publications

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“…Optimal levels of LH, FSH and testosterone are critical for spermatogenesis, and alterations of the balance of hormone levels result in spermatogenic malfunction (Anderson & Baird, 2002). In this study, sex hormone levels were not found to be affected by AgNP treatment, which is inconsistent with the results described in a previous publication (Dziendzikowska et al, 2016), further study need to be done to explain this difference. In this study, we observed changes of reproductive indicators and gene expression in testes after 125 mg/ kg AgNPs exposure, and no adverse effect was found in 30 mg/kg AgNPs and the control group.…”

Section: Discussioncontrasting

confidence: 99%

Alterations in reproductive parameters and gene expression in Balb/c mice testes after exposure to silver nanoparticles

Wang

Huang

et al. 2020

Andrologia

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Mammalian spermatogenesis starts shortly after birth from spermatogonial stem cells, which have the ability to self-renew, followed by differentiation of spermatogonia and the ultimate production of spermatozoa. The complex process of spermatogenesis is highly sensitive to environmental insults, such as exposure to chemical and physical factors. Nanoparticles (NPs) are defined as substances with a diameter in the range of 1-100 nm (Beer, Foldbjerg, Hayashi, Sutherland, & Autrup, 2012). Silver nanoparticle (AgNP) are commonly used in consumer products such as mobile phones, toothbrushes, medical instruments, scalpels and wound bandages, due to their antibacterial properties (Liu et al., 2018; Yoshida et al., 2018). Despite the widespread utility of NPs, emerging evidence suggests that excessive NP use may be hazardous to human health. NPs have been shown to easily traverse through biological membranes, including blood-brain and blood-testis barriers (Dubas

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Section: Discussioncontrasting

confidence: 99%

Alterations in reproductive parameters and gene expression in Balb/c mice testes after exposure to silver nanoparticles

Wang

Huang

et al. 2020

Andrologia

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“…Cholesterol enters the cell and is transported through the mitochondrial membrane by STAR-and PBR-dependent transport that regulates cholesterol participation in the synthesis of steroid hormones [23,50,52,53]. The mRNA levels of the key genes involved in cholesterol transport and testosterone synthesis, including 3β-HSD, 17β-HSD, P450-SCC, and P450 17α, are also important [32,54]. The levels of these genes were also increased in the F0 generation, except for 17β-HSD (Fig.…”

Section: Discussionmentioning

confidence: 90%

Maternal exposure of mice to sodium <i>p</i>-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring

Wang

Jin

et al. 2021

Endocr J

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The toxicity of certain novel perfluoroalkyl substances (PFCs) has attracted increasing attention. However, the toxic effects of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) on the endocrine system have not been elucidated. In this study, OBS was added to the drinking water during the pregnancy and lactation of the healthy female mice at dietary levels of 0.0 mg/L (CON), 0.5 mg/L (OBS-L), and 5.0 mg/L (OBS-H). OBS exposure during the pregnancy and lactation resulted in the presence of OBS residues in the placenta and fetus. We also analyzed physiological and biochemical parameters and gene expression levels in mice of the F0 and F1 generations after maternal OBS exposure. The total serum cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were significantly increased in female mice of the F0 generation. The androgen levels in the serum and the ovarian mRNA levels of androgen receptor (AR) also tended to increase after maternal OBS exposure in the F0 generation mice. Moreover, maternal OBS exposure altered the mRNA expression of endocrine-related genes in male mice of F1 generation. Notably, the serum TC and LDL-C levels were significantly increased in 8-weeks-old male mice of the F1 generation, and the serum high-density lipoprotein cholesterol (HDL-C) levels were decreased in 24-week-old male mice of the F1 generation. These results indicated that maternal OBS exposure can interfere with endocrine homeostasis in the F0 and F1 generations. Therefore, exposure to OBS during pregnancy and lactation has the potential toxic effects on the dams and male offspring, which cannot be overlooked.

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“…An in vitro study showed that NPs reduced mitochondrial and membrane functions of SSCs, causing production of steroid hormones by Leydig cells (Kim et al 2006). A study reported that AgNPs had altered the sex hormone concentration in the plasma and testes and the expression of genes involved in steroidogenesis and the steroids metabolism included, Star, Cyp11a1, Hsd3b1, Hsd17b3, and Srd5a1 were significantly down-regulated after male rats exposed to AgNPs/AgSPs (Dziendzikowska et al 2016). Moreover, AgNPs have interruption in functions of sex hormones, and can diminish the number of Leydig cells and sperm parameter indices (Baki et al 2014).…”

Section: Nps Disrupted Hormonesmentioning

confidence: 99%

Toxicity mechanisms of nanoparticles in the male reproductive system

Habas

Demir

Guo

et al. 2021

Drug Metabolism Reviews

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The field of nanotechnology has allowed for increasing nanoparticle (NP) exposure to the male reproductive system. Certain NPs have been reported to have adverse consequences on male germ and somatic cells. Germ cells are the bridge between generations and are responsible for the transmission of genetic and epigenetic information to future generations. A number of NPs have negative impacts on male germ and somatic cells which could ultimately affect fertility or the ability to produce healthy offspring. These impacts are related to NP composition, modification, concentration, agglomeration, and route of administration. NPs can induce severe toxic effects on the male reproduction system after passing through the blood-testis barrier and ultimately damaging the spermatozoa. Therefore, understanding the impacts of NPs on reproduction is necessary. This review will provide a comprehensive overview on the current state of knowledge derived from the previous in vivo and in vitro research on effects of NPs on the male reproductive system at the genetic, cellular, and molecular levels.

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Progressive effects of silver nanoparticles on hormonal regulation of reproduction in male rats

Cited by 40 publications

References 60 publications

Alterations in reproductive parameters and gene expression in Balb/c mice testes after exposure to silver nanoparticles

Alterations in reproductive parameters and gene expression in Balb/c mice testes after exposure to silver nanoparticles

Maternal exposure of mice to sodium <i>p</i>-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring

Toxicity mechanisms of nanoparticles in the male reproductive system

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