Progressive macular hypomelanosis in Singapore: a clinico‐pathological study

Kumarasinghe, Sujith Prasad; Tan, Suat Hoon; Thng, Steven Tien Guan; Thamboo, Thomas Paulraj; Shen, Liang; Lee, Yoke Sun

doi:10.1111/j.1365-4632.2006.02755.x

Cited by 34 publications

(49 citation statements)

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“…[1][2][3] In some patients, transient repigmentation is seen following exposure to sunlight. 4 The etiology of PMH is unknown and has been the subject of much research.…”

Section: Comunicationmentioning

confidence: 99%

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Uso da limeciclina associada com o peróxido de benzoíla no tratamento da hipomelanose macular progressiva: um estudo prospectivo

Cavalcanti

Querino

Magalhäes

et al. 2011

An. Bras. Dermatol.

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A hipomelanose macular progressiva é uma dermatose de etiopatogenia pouco conhecida. A participação do Propionibacterium acnes e a resposta ao tratamento com medicamentos com atividade para essa bactéria têm sido sugeridas. Relata-se uma série de casos de 13 pacientes com hipomelanose macular progressiva tratados com limeciclina e peróxido de benzoíla durante três meses, que apresentaram excelente resposta ao tratamento e nele se mantêm durante o período de seguimento do estudo

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“…[1][2][3] In some patients, transient repigmentation is seen following exposure to sunlight. 4 The etiology of PMH is unknown and has been the subject of much research.…”

Section: Comunicationmentioning

confidence: 99%

“…2 Resident Physician in Dermatology, University of Pernambuco (UPE), Recife, Pernambuco, Brazil. 3 PhD. Full Professor, Department of Infectious and Parasitic Diseases, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.…”

mentioning

confidence: 99%

Uso da limeciclina associada com o peróxido de benzoíla no tratamento da hipomelanose macular progressiva: um estudo prospectivo

Cavalcanti

Querino

Magalhäes

et al. 2011

An. Bras. Dermatol.

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“…The absence of patients over 40 years of age suggests that PMH may be a self-limiting disease, as has already been reported in other studies. 1,3,6 The time of progression of the disease was also found to be variable, ranging from 1 to 19 years.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions are asymptomatic and there have been no precedents of inflammatory lesions. [1][2][3][4][5] Its pathogenesis remains unclear. Some authors have suggested the effect of a subspecies of Propionibacterium acnes in the physiopathology of the condition.…”

Section: Introductionmentioning

confidence: 99%

Hipomelanose macular progressiva: estudo epidemiológico e resposta terapêutica à fototerapia

Duarte

Nina

Gordiano

et al. 2010

An. Bras. Dermatol.

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BACKGROUND: Progressive macular hypomelanosis is a common dermatosis in various continents. Its cause is unknown and proposed treatments have had little effect. OBJECTIVES: To determine epidemiological aspects of progressive macular hypomelanosis in patients referred to a phototherapy clinic between 1997 and 2008 and to evaluate therapeutic response to PUVA (psoralen + UVA) photochemotherapy or narrowband UVB phototherapy. METHODS: Eighty-four patients with progressive macular hypomelanosis were evaluated. After 16 phototherapy sessions, therapeutic response was classified as: unchanged, slightly improved (<50% of repigmentation), moderately improved (50-79% of repigmentation), much improved (80-99%) or cured (100%). After a minimum of three months, patients whose response was classified as cured or much improved were contacted by telephone to evaluate the persistence of the therapeutic response. RESULTS: Most of the patients were women (79%) and white (85%). Age at onset of progressive macular hypomelanosis ranged from 13 to 36 years. PUVA was prescribed for 27 patients and narrowband UVB phototherapy for 57. No significant difference was found between the outcomes obtained with PUVA and those obtained with narrowband UVB phototherapy (Fisher's exact test; p<0.05). The majority of patients (81%) had 50% or more repigmentation, with 65% being classified as cured or much improved. Nevertheless, there was a recurrence of the lesions in 72% of patients. CONCLUSIONS: The fact that no patients were over 40 years of age suggests that progressive macular hypomelanosis is a self-limiting disease. Both PUVA and narrowband UVB are effective therapeutic options; however, they do not prevent recurrence of the disease. Keywords: Phototherapy; Pigmentation disorders; Therapeutics Resumo: FUNDAMENTOS: A hipomelanose macular progressiva é uma dermatose comum em diferentes continentes. Sua causa é desconhecida e os tratamentos propostos são pouco eficazes. OBJETIVOS: Determinar aspectos epidemiológicos da hipomelanose macular progressiva em pacientes atendidos num setor de fototerapia, no período de 1997 a 2008, e avaliar a resposta terapêutica com PUVA ou UVBNB. MÉTODOS: Foram avaliados 84 pacientes com Hipomelanose Macular Progressiva. Após 16 sessões de fototerapia, a resposta terapêutica foi definida: I=inalterado, MD=melhora discreta(< 50% de repigmentação), MM=melho-ra moderada(50-79%), MI=melhora intensa(80-99%) e C=cura(100%). Após um tempo mínimo de três meses, pacientes com cura ou MI foram contatados por telefone para avaliar a manutenção do resultado terapêutico. RESULTADOS: Predominaram mulheres (79%) e a cor branca. A idade mínima de aparecimento da Hipomelanose Macular Progressiva foi de 13 anos e a máxima de 36 anos. Fototerapia com PUVA foi indicada em 27 pacientes e UVBNB em 57. Estatisticamente, não houve diferença significante entre o tratamento com PUVA e UVBNB (teste de Fisher P>0.05). A maioria (81%) dos pacientes obteve 50% ou mais de repigmentação e 65% tiveram cura ou MI. Entretanto, 72% apres...

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“…. ‹mmünohistokimya: Yap›lan çal›flmalarda hipopigmente maküller ile komflu sa¤lam deri, melanosit morfolojileri ve say›la-r› bak›m›ndan immunhistokimyasal olarak S-100 boyama ile karfl›laflt›r›ld›¤›nda anlaml› fark bulunmam›flt›r 6,11 . Wu ve arkadafllar› S-100 boyas› melanositlere spesifik olmad›¤›ndan immunhistokimyasal olarak S-100 yan›nda tirozinaz related protein 1 (TRP-1) ve tirozinaz (T311) boyalar› da kullanm›fllar ancak her üç boyamada da normal deri ile karfl›laflt›r›ld›¤›nda hipopigmente maküllerde melanosit say›s› ve morfolojisi aç›s›n-dan istatistiksel olarak anlaml› fark saptamam›fllard›r 3 .…”

Section: Epidemiyolojik Ve Klinik öZelliklerunclassified

Progresif Maküler Hipomelanozis

Mevlitoğlu¹,

Aykol²

2011

Turkderm

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Progresif maküler hipomelanozis (PMH) ilk olarak 1988 y›l›nda Guillet taraf›ndan tan›mlanm›flt›r. PMH s›kl›kla gövdeyi tutan, asemptomatik, zor fark edilen, numuler, skuams›z, hipopigmente maküllerle karakterizedir. PMH ço¤unlukla adölesan ve genç kad›nlarda görülür. Etyopatogenezi hala bilinmemektedir. Wood lambas› alt›nda hipopigmente maküllerde k›rm›z› foliküler florasan görünürken komflu normal deride florasan gözlenmez. PMH'nin histopatolojik bulgular› genellikle non-spesifiktir, ancak hipopigmente maküllerin melanin içeri¤inin normal deriye göre azalm›fl olmas› s›k görülen bir bulgudur. Etkili bir tedavi halen bilinmemektedir. Ancak fototerapi PMH'yi kontrol alt›na almada etkili bulunmufl olmas›na karfl›n hastal›¤›n rekürrensini önlememektedir. Biz bu makalede PMH'nin etyopatogenezi, klinik bulgular›, histopatolojisi, ay›r›c› tan›s› ve tedavi seçeneklerini derlemeyi amaçlad›k. (Türkderm 2011; 45: 62-5) Anahtar Kelimeler: Progresif maküler hipomelanozis, pigmentasyon bozukluklar› SummaryProgressive macular hypomelanosis (PMH) was initially described and named by Guillet in 1988. PMH is characterized by asymptomatic, ill-defined, nummular, non-scaly, hypopigmented macules, localized predominantly on the trunk. PMH is mostly seen in adolescents and young females. The etiopathogenesis of PMH is still unknown. The red follicular fluorescence becomes visible in the hypopigmented macules under Wood's lamp but is absent in normal adjacent skin. The histopathologic findings in PMH are usually non-specific, but a common feature is the decreased melanin content in the hypopigmented macules compared to the normal skin. No effective therapy is currently known. Phototherapy was found to be effective for the control of PMH; however, it does not prevent recurrence of the disease. In this paper, we aimed to review the etiopathogenesis, clinical findings, histopathology, differential diagnosis and treatment options of PMH. (Turkderm 2011; 45: 62-5

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Progressive macular hypomelanosis in Singapore: a clinico‐pathological study

Abstract: PMH may occur among young adults in Singapore. Its etiology is uncertain. The melanin content of lesional skin appears to be less than that in normal sites. EM shows a higher ratio of immature melanosomes in lesional vs. normal skin.

Cited by 34 publications

References 4 publications

Uso da limeciclina associada com o peróxido de benzoíla no tratamento da hipomelanose macular progressiva: um estudo prospectivo

Uso da limeciclina associada com o peróxido de benzoíla no tratamento da hipomelanose macular progressiva: um estudo prospectivo

Hipomelanose macular progressiva: estudo epidemiológico e resposta terapêutica à fototerapia

Progresif Maküler Hipomelanozis

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