Progressive morphologic changes in electrolytic brain lesions

Wolf, George; DiCara, Leo V.

doi:10.1016/0014-4886(69)90122-8

Cited by 68 publications

(21 citation statements)

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“…Significant degeneration of efferent or afferent connections of a lesioned region often requires at least 1 week (Gage et al, 1986;Pallini et al, 1988;Sauer and Oertel, 1994), rendering this explanation unlikely. More probable is that short-term degenerative changes surrounding the lesion occurred within days after surgery, thereby increasing the size as well as the effectiveness of the neural insult (Wolf and DiCara, 1969;Oestreicher et al, 1988;Pschorn et al, 1993). This expansion of apparent lesion size continues through the first 2 weeks after surgery (Wolf and DiCara, 1969), a likely explanation of larger lesions in dams killed 12-14 d after prepartum PAG-x versus only 7 d after postpartum surgery.…”

Section: Comparison Of Pre-and Postpartum Pag Lesionsmentioning

confidence: 99%

“…More probable is that short-term degenerative changes surrounding the lesion occurred within days after surgery, thereby increasing the size as well as the effectiveness of the neural insult (Wolf and DiCara, 1969;Oestreicher et al, 1988;Pschorn et al, 1993). This expansion of apparent lesion size continues through the first 2 weeks after surgery (Wolf and DiCara, 1969), a likely explanation of larger lesions in dams killed 12-14 d after prepartum PAG-x versus only 7 d after postpartum surgery. (PAG-x) carried out prepartum (gestation day 15-17) or postpartum (day 7) on lactating rat dams' behavior (means ؎ SEM) toward a strange male intruder (maternal aggression) in 5 or 10 min tests, respectively cPAG lesions performed either pre-or postpartum produced strikingly similar results, indicating effects on both the onset and maintenance of kyphosis and maternal aggression.…”

Section: Comparison Of Pre-and Postpartum Pag Lesionsmentioning

confidence: 99%

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Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression:c-fosand Electrolytic Lesion Studies in Lactating Rats

1997

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The upright crouched, or kyphotic, nursing posture of lactating rats is dependent on suckling stimulation from pups. Because of the neuroanatomical connections of the periaqueductal gray (PAG) and its sensorimotor integration of the analogous lordosis posture displayed by sexually receptive female rats, the possible role of the PAG in kyphosis was investigated using c-fos immunocytochemistry and electrolytic lesions. Lactating rats interacting with and nursing a litter of suckling pups showed greater Fos-immunoreactive nuclei in the lateral and ventrolateral caudal PAG (cPAG l,vl ) compared with dams receiving nonsuckling somatosensory, distal, or no stimulation from pups. In contrast, this pattern was not evident in the rostral PAG, where the highest Fos levels occurred in nonsuckled dams, or in five other brainstem sites with either no group differences (peripeduncular, dorsal raphe, and pontine nuclei) or negligible Fos (ventral tegmental area, spinal trigeminal nuclei). After bilateral electrolytic lesions of the cPAG l,vl during gestation or on day 7 postpartum, active maternal behaviors, such as retrieval and licking of pups, and total nursing time were essentially normal. Kyphotic nursing, however, was reduced by 85%, nursing in prone and supine postures increased substantially, and 24 hr litter weight gains were reduced, particularly early in lactation (by 26%). Furthermore, lesioned rats attacked a strange male twice as often as controls did, which is suggestive of reduced fearfulness. These results extend the known roles of the PAG in reproductive and defensive behaviors to the postural control of suckling-induced kyphotic nursing and the modulation of maternal aggression.

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Section: Comparison Of Pre-and Postpartum Pag Lesionsmentioning

confidence: 99%

Section: Comparison Of Pre-and Postpartum Pag Lesionsmentioning

confidence: 99%

Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression:c-fosand Electrolytic Lesion Studies in Lactating Rats

1997

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“…Lymphohistiocytic infiltration of the perimeter and, in most cases, an aggregation of polymorphonuclear leukocytes in the open space at the cannula tip are apparent, but the occurrence of any specific cell type did not correlate reliably with the behavioral data. Evidence for any extensive lysis or necrosis like that described for electrolytic lesions (16) was not found.…”

Section: Antigen-antibody Reactions In Rat Brain Sites Induce Transiementioning

confidence: 70%

Antigen-Antibody Reactions in Rat Brain Sites Induce Transient Changes in Drinking Behavior

Williams¹,

Schupf²

1977

Science

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The septum or hypothalamus of rat brain was injected through implanted cannulas with antibody against membrane antigens in the rat brain or with antibody against exogenous soluble antigens (such as ovalbumin) followed by the specific antigen. Both immunological systems produced a moderate but highly significant decrease in drinking by thirsty rats. This phenomenon is suggested as an experimental model for behavioral disorders resulting from nondegenerative, immunological processes in the brain.

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“…The experimental procedures were performed on 15 th day to assess the immunity status of the animals. It has been reported that in lesions produced in the caudate nucleus and also in hypothalamus of rats by passing direct anodal current through sterotaxically inserted electrodes, the apparent lesion size increases during the first postoperative day and then decreases progressively after the first postoperative week with contraction of the central cavity and disappearance of neuroglia cells 33 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2012

IJPSR

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The aim of the present study was to investigate the role of cerebellum in immunomodulation as cerebellum was thought traditionally to play an important role in voluntary motor activities. Rats weighing about 200-220 gm were subjected to bilateral electrolytic lesion of fastigial nucleus and following immune parameters were assessed-leucocyte migration inhibition test, foot pad thickness, antibody titre and estimation of cytokines -IL-2, IL-4 and IFN-γ respectively in immunized animals. Rats were divided in to three groups, namely control immunized, sham immunized and lesioned immunized groups. The sham group was strictly considered for evaluation of lesion effect as superficial structures during surgical procedure gets damaged and could also influence on immunomodulation. The significance was fixed at P<0.05. There was significant increase in migration index with concomitant decrease in foot pad thickness in bilateral lesion immunized groups. Significant alterations in cytokine levels were observed in lesion immunized groups when compared with its respective control groups.

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Progressive morphologic changes in electrolytic brain lesions

Cited by 68 publications

References 4 publications

Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression:c-fosand Electrolytic Lesion Studies in Lactating Rats

Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression:c-fosand Electrolytic Lesion Studies in Lactating Rats

Antigen-Antibody Reactions in Rat Brain Sites Induce Transient Changes in Drinking Behavior

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