Progressive nodular histiocytosis accompanied by systemic disorders

Ruiz, A; Ruiz, Ana Isabel Bernal; Fraile, Henar Aragoneses; Martínez, Isabel Peral; Muñoz, M. García

doi:10.1111/j.1365-2133.2000.03723.x

Cited by 57 publications

(37 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lesions seemed to spread in a cranial to caudal fashion, something not previously noted. Unlike other patients in the literature [15,[18][19][20] our patients fortunately did not have large or severely disfi guring facial nodules. They did have involvement of the joint fl exures, which has been uncommon in other reports [5,21].…”

Section: Commentscontrasting

confidence: 63%

See 1 more Smart Citation

Progressive nodular histiocytosis

Hilker

Kovneristy²,

Varga³

et al. 2012

J Deutsche Derma Gesell

View full text Add to dashboard Cite

SummaryProgressive nodular histiocytosis (PNH) represents a very rare type of non-Langerhans cell histiocytosis (NLCH). It can be distinguished from other types by the occurrence of yellow to red-brown papules and nodules measuring a few centimeters in size. Histologically the nodules represent spindle-cell xanthogranulomas. We report on two new cases of PNH with novel clinical symptoms. In the first case, the patient had microcytic anemia due to massive iron deposition in the nodules and a progressively worsening limp due to involvement of the soles. The complex therapeutic challenge was effectively managed by successive surgical ablation of all visible lesions. The second patient had epibulbar infiltrates. The clinical variability of PNH leads to considerable overlap with other forms of NLCH.

show abstract

Section: Commentscontrasting

confidence: 63%

“…The disease can also affect children [1,13,14]. Except for one patient with an association with leukemia [15], there seems to be no association with malignancies or chronic infl ammatory diseases. Distinction from generalized eruptive histiocytomas in particular may be diffi cult [16].…”

Section: Commentsmentioning

confidence: 99%

Progressive nodular histiocytosis

Hilker

Kovneristy²,

Varga³

et al. 2012

J Deutsche Derma Gesell

View full text Add to dashboard Cite

show abstract

“…3 One case report described carbon dioxide laser treatment of PNH nodules, but there was recurrence of lesions over the scar tissue. 6 Systemic vincristine combined with prednisolone treatment has been reported to be unsuccessful. 9 Our patient developed skin lesions prior to, during, and after RCHOP therapy, so this chemotherapeutic regimen was not an effective treatment for his skin disease.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] Most patients with PNH have no systemic involvement, but there have been a few reported cases of associated malignancies. 5,6 The clinical course is characterized by the progressive appearance of new lesions.…”

Section: Discussionmentioning

confidence: 99%

Reddish-Brown Nodules and Papules in an Elderly Man

et al. 2013

View full text Add to dashboard Cite

A man in his 70s with a 4-year history of stage IV chronic lymphocytic leukemia (CLL) presented with a 12-month history of an asymptomatic skin eruption. His CLL had been in remission for 2 years after treatment with fludarabine and rituximab before he relapsed and underwent 6 cycles of RCHOP treatment (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). During his CLL relapse, he developed cutaneous nodules on his face that then spread diffusely. The patient denied fevers, arthralgias, bone pain, polydipsia, or polyuria. Physical examination revealed multiple 0.5-to 1.5-cm reddish-brown firm papules and nodules on his cheeks, torso, buttocks, and extensor surfaces of his extremities (Figure, A), sparing his eyelids, palms, soles, and mucous membranes. Triglyceride levels were mildly elevated at 211 mg/dL; otherwise the patient's lipid levels were normal (to convert triglycerides to millimoles per liter, multiply by 0.0113). A biopsy of a representative papule on the thigh was performed, and a routine hematoxylin-eosinstained section (Figure, B) and CD68 immunohistochemically stained section (Figure, C) are shown. Findings of CD1a and S100 stainings were negative.

show abstract

“…While PNH is considered to be one of the cutaneous histiocytoses without significant systemic involvement, there are scattered case reports describing associations with systemic illnesses and tumors. 3,4 The course of the disease is unfortunately progressive, resistant to therapy, and disfiguring. 5,6 The case reported herein showed the characteristic cutaneous lesions consistent with PNH, with extensive involvement of the face.…”

mentioning

confidence: 99%