2012
DOI: 10.3791/3754-v
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Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

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Cited by 8 publications
(11 citation statements)
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“…After a training period of about 7-10 days when three successive sessions of obtaining equal and more than 20 pellets during the FR1 session of 45 min, mice were then engaged in consecutive PR sessions of 45 min. For the PR session, the number of lever presses required for one food pellet delivery followed the order (calculated by the formula [5e (R*0.2) ]−5 where R is equal to the number of food rewards already earned plus 1): 1, 2, 4, 6, 9, 12, 15, 20, and so on [40]. The maximal number of active lever presses performed to reach the final ratio was defined as the breakpoint, a value reflecting animals' motivation to get the food reward.…”
Section: Stereotactic Surgery For Cannula Implantationmentioning
confidence: 99%
“…After a training period of about 7-10 days when three successive sessions of obtaining equal and more than 20 pellets during the FR1 session of 45 min, mice were then engaged in consecutive PR sessions of 45 min. For the PR session, the number of lever presses required for one food pellet delivery followed the order (calculated by the formula [5e (R*0.2) ]−5 where R is equal to the number of food rewards already earned plus 1): 1, 2, 4, 6, 9, 12, 15, 20, and so on [40]. The maximal number of active lever presses performed to reach the final ratio was defined as the breakpoint, a value reflecting animals' motivation to get the food reward.…”
Section: Stereotactic Surgery For Cannula Implantationmentioning
confidence: 99%
“…S1, G and H). Using operant behavioral tests under both fixed-ratio (FR) and progressive-ratio (PR) schedules of reinforcement ( 25 ), we found that mice with VTA DA ablation had significantly lower active lever presses during both FR and PR sessions and breakpoints for food reward during PR sessions under fed but not fasted conditions (fig. S1, I to L).…”
Section: Resultsmentioning
confidence: 99%
“…After a training period of about 7 to 10 days when three successive sessions of obtaining equal and more than 20 pellets during the FR1 session of 45 min, mice were then engaged in consecutive PR sessions of 45 min. For the PR session, the number of lever presses required for one food pellet delivery followed the order (calculated by the formula [5 e ( R *0.2) ] − 5 where R is equal to the number of food rewards already earned plus 1): 1, 2, 4, 6, 9, 12, 15, 20, and so on ( 25 ). The maximal number of active lever presses performed to reach the final ratio was defined as the breakpoint, a value reflecting animals’ motivation to get the food reward.…”
Section: Methodsmentioning
confidence: 99%
“…Instrumental Training and Progressive Ratio were used to assess appetitive learning and motivation (Sharma et al, 2012). Mice were food restricted up to 5 days a week with ad lib food at least 2 days a week to maintain at 85% of their free-feeding weight.…”
Section: Methodsmentioning
confidence: 99%