Progressive study on ruthenium catalysis for de(hydrogenative) alkylation and alkenylation using alcohols as a sustainable source

Abstract

At present, alcohols are discovered as sustainable starting materials that can be used in organic synthesis for various organic transformations and the preparation of commodity chemicals. Acceptorless Dehydrogenation (AD) and...

Harnessing alcohols as sustainable reagents for late-stage functionalisation: synthesis of drugs and bio-inspired compounds

“…However, due to the increase in the number of catastrophic diseases (such as SARS-COVID) worldwide, 13,14 the use of innovative techniques for manufacturing pharmaceuticals or drug derivatives has been gaining increasing attention. [7][8][9][10][11][12][15][16][17][18][19] Notably, Bruke published two reviews on automation techniques for synthesising various small molecules with biological potential using MIDA (N-methyliminodiacetic acid) boronate as a crosscoupling reagent. 20,21 Recently, Waldmann also documented and highlighted the synthetic potential of natural product-like molecules towards drug development.…”

Microwave-assisted pincer-ruthenium catalyzed Guerbet reaction for the upgradation of bio-ethanol to bio-butanol

“…710 TO h −1 ). 18 These reactions were performed under conventional heating (140 °C) and took longer times (72 h) to complete, which is typical of the Guerbet reaction. In this context, in this study, we investigated the activity of NNN pincer-Ru catalysts ( 1a–d , 2a–d , 4a–b and 5a–b ) (Fig.…”

β‐Alkylation through Dehydrogenative Coupling of Primary Alcohols and Secondary Alcohols Catalyzed by Thioether‐Functionalized N‐Heterocyclic Carbene Ruthenium Complexes

“…In 2003, the Cho group reported for the first time a tandem β‐alkylation of secondary alcohols catalyzed by RuCl 2 (PPh 3 ) 3 in the presence of an excess of hydrogen acceptors [12] . Following this seminal result, several publications have emerged, dominated by second and third row transition metals, on the use of complexes based on Ir, [13] Pd, [14] Rh [9] and Ru [8a,15] for the same reaction following the HA or BH methodology [2a,c,d] …”