Progressive Worsening of Spatial and Chromatic Processing Deficits in Parkinson Disease

Diederich, Nico J.; Raman, Rema; Leurgans, Sue E.; Goetz, Christopher G.

doi:10.1001/archneur.59.8.1249

Cited by 122 publications

(89 citation statements)

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“…Sensory deficits have been documented in PD, particularly in the olfactory and visual domains [5][6][7][21][22]. Visual deficits in PD are subtle and not likely to be discovered during routine neurological examination.…”

Section: Discussionmentioning

confidence: 99%

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Subjective visual vertical perception and sense of smell in Parkinson disease

Khattab¹,

Docherty²,

Bagust³

et al. 2012

JRRD

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Abstract-Thisarticle describes an open cross-sectional observational study involving 47 participants with Parkinson disease (PD) and 47 (age-and sex-matched) nondisabled controls without PD. The aim was to determine the profiles of subjective visual vertical (SVV) perception and sense of smell perception in both groups. There was a statistically significant difference (p < 0.001) between patients and controls on their smell test performance. Controls were more likely to correctly identify odors, with a median score of 10 out of 12 compared with 6.5 out of 12 for patients with PD. The median SVV error for the PD group when the frame was untilted was 0.75 degrees compared with 0.50 degrees for controls. This difference was statistically significant (p = 0.02). When the frame was tilted, the median SVV error for the PD group was 2.31 degrees compared with 2.00 degrees for controls (not statistically significant), with both groups showing similar distribution pattern of errors. There was no statistical correlation between number of correctly identified odors and an individual's SVV error. However, a statistically significant negative correlation (r = 0.45, p = 0.01) was found between Mini-Mental State Examination score and mean time taken to complete each rod and frame test in patients with PD, suggesting that SVV errors might be more correlated with cognitive function than with loss of sense of smell.

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Section: Discussionmentioning

confidence: 99%

“…Patients with PD were reported to have reduced visual acuity [5], color vision [6], and contrast sensitivity [7]. It has also been reported that there is an increased visual dependence perceptually in patients with PD [8].…”

Section: Introductionmentioning

confidence: 99%

Subjective visual vertical perception and sense of smell in Parkinson disease

Khattab¹,

Docherty²,

Bagust³

et al. 2012

JRRD

View full text Add to dashboard Cite

show abstract

“…One of the most typical features of PD is reduced contrast sensitivity (CS), which is also assessed by psychophysiological methods [4,5]. In this respect, Hamilton test, Pelli-Robsons charts and software options such as Zebra 3 showing different chromatic and achromatic sinusoidal grids of different spatial frequency.…”

Section: IIImentioning

confidence: 99%

“…Later studies showed that defects in the visual system contribute greatly to motor disorders in PD, such as freezing, walking disturbance, postural disorder and falls, and can also, among other factors, induce visual hallucination [5,6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Oa¹,

Sa²,

Oi³

2017

JNSK

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Among non-motor symptoms in patients with Parkinson's disease (PD) have a number of specific visual disturbances. This review describes the main visual problems associated with PD, referring to their basic anatomical aspects and pathophysiological mechanisms. A wide range of visual disorders includes changes in color vision and contrast sensitivity, change in the electrophysiological properties of the retina due to the insufficiency of the retinal dopaminergic system, features of visual field defects, visuospatial and visuoperceptual impairments. The use of modern electrophysiological, neurophysiological, psychophysiological and other research methods makes it possible to comprehensively assess the state of all parts of the visual analyzer from the retina to the higher cortical centers in patients with PD. The article discusses controversial questions about the relationship between changes in color vision, a decrease in the level of contrast sensitivity and severity of motor disorders in Parkinson's disease. Finally, we discuss the advantages of using threshold and blue-yellow perimetry as more sensitive methods in detecting visual field defects in patients with PD. Keywords:

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“…Color vision abnormalities are among the non-motor clinical characteristics of PD (Prise et al, 1992;Büttner et al, 1995), and impairments in color discrimination and contrast sensitivity in PD are progressive over time (Diederich et al, 2002). The severity of the axial www.intechopen.com motor symptoms has been shown to be more closely related to visual dysfunction than mental function.…”

Section: Color Discriminationmentioning

confidence: 99%

Combinations of Markers Provide Clues to the Underlying Neurodegenerative Disorder in REM Sleep Behavior Disorder

Miyamoto¹,

Miyamoto²

2011

Diagnosis and Treatment of Parkinson's Disease

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Progressive Worsening of Spatial and Chromatic Processing Deficits in Parkinson Disease

Abstract: Impairments of CD and CS in PD are progressive over time. Visual deficits may influence overall motor function and lead to enhanced motor impairment.

Cited by 122 publications

References 10 publications

Subjective visual vertical perception and sense of smell in Parkinson disease

Subjective visual vertical perception and sense of smell in Parkinson disease

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Combinations of Markers Provide Clues to the Underlying Neurodegenerative Disorder in REM Sleep Behavior Disorder

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