Proinflammatory Plasma Cytokines in Children With Migraine

Boćkowski, Leszek; Sobaniec, Wojciech; Żelazowska-Rutkowska, Beata

doi:10.1016/j.pediatrneurol.2009.02.001

Cited by 54 publications

(38 citation statements)

References 23 publications

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“…Epidemiological evidence suggests that there are two general categories of explanation for severe prematurity that may relate to less severe prematurity as well: inflammation as indicated by histological chorioamnionitis and recovery of placental microorganisms, and disordered placentation indicated by pre-eclampsia or intrauterine growth restriction. 19 There is evidence that migraine is associated with markers of inflammation, such as elevated C-reactive protein and of homocysteine, 20 (although that evidence is not unambiguous 21 ) and in children with elevated levels of certain cytokines, 22 and with disorders such as asthma that have an inflammatory component. 1 Migraine and pre-eclampsia Since 1959, reports have associated migraine with approximately a doubling of risk of pre-eclampsia.…”

Section: Migraine and Preterm Birthmentioning

confidence: 99%

Migraine and preterm birth

Blair

Nelson

2010

J Perinatol

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Objective: To investigate whether maternal migraine was associated with preterm birth.Study Design: Case-control sample within a population-based study of risk factors for cerebral palsy (CP). Infants without CP were matched for gestational age with those with CP. Maternal migraine was self-identified at first prenatal visit, most in the first trimester.Result: Infants without CP born to women with migraine had a higher rate of preterm birth (odds ratio (OR) ¼ 3.5, 95% confidence interval (CI) 1.5, 8.5), as did infants who died in the perinatal period (OR ¼ 7.3, 95% CI 0.98, 54), the difference marginal for nominal statistical significance. In all outcome groups, infants of women with migraine had a higher observed rate of suboptimal intrauterine growth. In term infants, the rate of maternal migraine was higher in those with CP than in controls (OR ¼ 2.18, 95% CI 0.92, 5.25). Pre-eclampsia was reported more frequently in women with migraine who gave birth to a child with CP or a perinatal death, particularly in those born preterm; OR ¼ 5.1 (1.3, 20) and OR ¼ 2.9 (1.1, 7.6), respectively, but not in women giving birth to a control whether term or preterm.Conclusion: Maternal migraine, as self-reported early in pregnancy, was associated with preterm birth in survivors without CP and in infants who died in the perinatal period. The combination of maternal migraine and pre-eclampsia was associated with CP and perinatal death. The association of maternal migraine with outcomes of pregnancy warrants further study.

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Section: Migraine and Preterm Birthmentioning

confidence: 99%

Migraine and preterm birth

Blair

Nelson

2010

J Perinatol

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“…Our previous studies suggest an important role of changes of serum levels of cytokines and lipid peroxidation factors in the pathogenesis of acute and chronic diseases of the central nervous system [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome.

Śmigielska-Kuzia

Boćkowski²,

Sobaniec³

et al. 2011

Folia Histochem Cytobiol.

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Cytokines participate in many physiological processes including the regulation of immune and inflammatory responses. Production of some important cytokines in children with Down syndrome (DS) is depressed or increased . In this study we analysed the selected anti-inflammatory cytokines: interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-13 (IL-13) in plasma of children and adolescents with DS. The study group consisted of 20 patients with Down syndrome and 33 healthy subjects at the age of 5-17 years. Levels of: IL-4, IL-10 and IL-13 in plasma samples were determined by specific enzyme-linked immunosorbent assay (ELISA) techniques according to manufacturer's instructions. IL-4 was detectable in 25% subjects with Down syndrome and in 28.6% healthy subjects. IL-13 was detectable in 15% patients with Down syndrome and in 15.2% healthy subjects, respectively. IL-10 was detectable in 1 of 20 patients with Down syndrome and in 2 of 33 healthy subjects only. No significant correlations between measurable cytokine levels and age and gender were found. No significant increased concentration of selected anti-inflammatory cytokines were detected.

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“…It is further hypothesized that this activity may lead to downstream activation of pro-inflammatory mediators such as interleukin 1 (IL-1) and bradykinin [6]. In support, there are studies showing an increased level of the pro-inflammatory tumour necrosis factor α (TNFα) in acute as well as chronic migraine patients when compared with tension type headache and controls [7–9]; in addition, TNFα may increase the production of CGRP [10]. Administration of nitroglycerine can result in an inflammatory response in the dura mater with upregulation of IL-1β and IL-6 [11].…”

Section: Introductionmentioning

confidence: 99%

Neurogenic inflammation: a study of rat trigeminal ganglion

Kristiansen

Edvinsson

2010

J Headache Pain

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Calcitonin gene-related peptide (CGRP) is linked to neurogenic inflammation and to migraine. Activation of the trigeminovascular system plays a prominent role during migraine attacks with the release of CGRP. The trigeminal ganglion (TG) contains three main cell types: neurons, satellite glial cells (SGC) and Schwann cells; the first two have before been studied in vitro separately. Culture of rat TG provides a method to induce inflammation and the possibility to evaluate the different cell types in the TG simultaneously. We investigated expression levels of various inflammatory cytokines on mRNA level using RT-PCR arrays and qRT-PCR; furthermore expression at protein level was studied using immunohistochemistry. We report that (1) organ culture of the TG is possible with preserved morphology, (2) organ culture is associated with enhanced expression of cytokines and mitogen-activated protein kinases (MAPKs) primarily in neurons, (3) CGRP can induce expression of some cytokines and (4) cytokine expression is still upregulated following MAPK pathway inhibition by MEK inhibitor U0126 and pp38 inhibitor SB202192, but the cytokine expression is abolished when co-incubating with the JNK inhibitor SP600125. This method may be of value to examine local TG inflammation, putatively involved in the pathophysiology of some forms of primary headaches.

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Proinflammatory Plasma Cytokines in Children With Migraine

Cited by 54 publications

References 23 publications

Migraine and preterm birth

Migraine and preterm birth

Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome.

Neurogenic inflammation: a study of rat trigeminal ganglion

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