1990
DOI: 10.1007/bf00586459
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Proinsulin and C-peptide at onset and during 12 months cyclosporin treatment of Type 1 (insulin-dependent) diabetes mellitus

Abstract: Smnmary. An increased proinsulin to C-peptide molar ratio at the onset of Type i (insulin-dependent) diabetes mellitus has been suggested. We studied fasting proinsulin levels and proinsulin/C-peptide ratios in the newly diagnosed diabetic subjects participating in the Canadian/European placebo controlled cyclosporin study at entry, during the one year treatment period and six months of follow-up. Available entry data from 176 out of the 188 allocated patients were compared to 60 age and weight matched control… Show more

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Cited by 43 publications
(37 citation statements)
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“…That is, in a situation with a sustained hypersecretion of insulin, the b-cells therefore seem to be unable to sufficiently enhance the conversion of proinsulin to maintain a normal ratio in the secretory granule. This is, in line with clinical observations where increased proportion of proinsulin in the plasma of diabetic patients as well as in glucose intolerant subjects was published (Duckworth & Kitabchi 1972, Gordon et al 1974, Mako et al 1977, Heding et al 1981, Ludvigsson & Heding 1982, Rhodes & Halban 1987, Hartling et al 1989, Snorgaard et al 1990). …”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…That is, in a situation with a sustained hypersecretion of insulin, the b-cells therefore seem to be unable to sufficiently enhance the conversion of proinsulin to maintain a normal ratio in the secretory granule. This is, in line with clinical observations where increased proportion of proinsulin in the plasma of diabetic patients as well as in glucose intolerant subjects was published (Duckworth & Kitabchi 1972, Gordon et al 1974, Mako et al 1977, Heding et al 1981, Ludvigsson & Heding 1982, Rhodes & Halban 1987, Hartling et al 1989, Snorgaard et al 1990). …”
Section: Discussionsupporting
confidence: 89%
“…Increased levels of proinsulin have also been found at the onset of type I diabetes (T1D) and in relatives of T1D patients (Ludvigsson & Heding 1982, Hartling et al 1989, Snorgaard et al 1990. In rat models of hyperglycaemia, increased ratios of circulating proinsulin to insulin have been determined (Leahy et al 1991, Leahy 1993, Alarcon et al 1995, Gadot et al 1995.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, when classifying for remission, CCL3 revealed an opposed longitudinal course for remitters versus non-remitters. CCL3 showed a negative association with C-peptide and a positive association with proinsulin that is not only a precursor of C-peptide but has also been described as a marker for β-cell stress [28][29][30]. Interestingly, in the prospective model CCL3 was negatively associated with HbA1c and might support the assumption of enforced leukocyte attraction due to the presence of more insulin producing β-cells and confirms observations between CCL3 and remission.…”
Section: Discussionsupporting
confidence: 76%
“…To our knowledge, this is a new observation. Previously, high PIM concentrations have been found in patients with newly diagnosed IDDM (26,27). The influence of PIM bound to insulin antibodies on the measured circulating concentration of PIM should be borne in mind (28).…”
Section: Discussionmentioning
confidence: 97%