Projection of limb venous afferents to the feline motor-sensory cortex

Thompson, Floyd J.; Lerner, D.N.; Fields, Kathy; Blackwelder, Aaron

doi:10.1016/0165-1838(80)90005-3

Cited by 14 publications

(6 citation statements)

References 14 publications

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“…Studies in cats demonstrate that afferents from femoral-saphenous (49,50,54) and triceps surae muscle veins (17) sense the limb venous distension (11,17,39). Our report demonstrates that this reflex is indeed present and quite active in humans.…”

Section: Perspective On the Importance Of The Limb Venous Distension supporting

confidence: 55%

Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans

Cui

McQuillan²,

Blaha

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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We have recently shown that a saline infusion in the veins of an arterially occluded human forearm evokes a systemic response with increases in muscle sympathetic nerve activity (MSNA) and blood pressure. In this report, we examined whether this response was a reflex that was due to venous distension. Blood pressure (Finometer), heart rate, and MSNA (microneurography) were assessed in 14 young healthy subjects. In the saline trial (n = 14), 5% forearm volume normal saline was infused in an arterially occluded arm. To block afferents in the limb, 90 mg of lidocaine were added to the same volume of saline in six subjects during a separate visit. To examine whether interstitial perfusion of normal saline alone induced the responses, the same volume of albumin solution (5% concentration) was infused in 11 subjects in separate studies. Lidocaine abolished the MSNA and blood pressure responses seen with saline infusion. Moreover, compared with the saline infusion, an albumin infusion induced a larger (MSNA: Δ14.3 ± 2.7 vs. Δ8.5 ± 1.3 bursts/min, P < 0.01) and more sustained MSNA and blood pressure responses. These data suggest that venous distension activates afferent nerves and evokes a powerful systemic sympathoexcitatory reflex. We posit that the venous distension plays an important role in evoking the autonomic adjustments seen with postural stress in human subjects.

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Section: Perspective On the Importance Of The Limb Venous Distension supporting

confidence: 55%

Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans

Cui

McQuillan²,

Blaha

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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“…Thinly myelinated and unmyelinated aVerents of the veins respond to mechanical stimuli of high intensities (Davenport and Thompson 1987). In cats, stimulation of venous nerve aVerents elicits responses in the motorsensory cortex (Thompson et al 1980). The functional role of venous aVerents in physiological and/or pathophysiological contexts is not known (Göder et al 1993).…”

Section: Pressure-induced Vascular Painmentioning

confidence: 98%

Distensibility in human veins as affected by 5 weeks of repeated elevations of local transmural pressure

Kölegård

Eiken

2011

Eur J Appl Physiol

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The objectives were to investigate the effects of repeated increments in local intravascular pressure (pressure training; PT) on (1) distensibility in two arm veins, and (2) pain in the arm induced by markedly increased intravascular pressure. Elevation of venous distending pressure (DP) in an arm was induced by placing the subject (n = 8) in a pressure chamber with one arm protruding to the outside via a port in the chamber door, and increasing chamber pressure. During 5 weeks, venous DP in one arm was repeatedly (3 × 40 min/week) increased (65-105 mmHg). Pressure-distension relationships were determined in the brachial and cephalic veins by measuring diameter changes by ultrasonography during stepwise increments in DP to 180 mmHg. In the brachial vein, the diameter change in response to an increase in DP from 30 to 180 mmHg (distensibility) was reduced (P < 0.05) in the pressure-trained arm (11%) compared to that in the control arm before (23%) and after (21%) PT. The cephalic vein showed a similar response with a reduced (P < 0.05) distensibility in the pressure-trained arm (20%) compared to that in the control arm before (29%) and after (25%) PT. At any given DP, arm pain was less (P < 0.05) in the pressure-trained arm than in the control arm before and after PT, presumably reflecting the reduced venous distensibility in the pressure-trained arm. The results support the concept that the distensibility of venous walls adapts to meet the demands imposed by the prevailing local transmural pressures.

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“…Blocking studies indicated that the vasoconstriction was mediated by a local (axonal) sympathetic reflex mechanism. Activation of venous afferent fibers producing reflex-induced leg muscle activity may also counteract postural pooling (330,331).…”

Section: Dynamic Responses To Posture Changesmentioning

confidence: 99%