Projection of osteoporosis-related fractures and costs in China: 2010–2050

Liu, Si; Winzenberg, Tania; Jiang, Qichen; Chen, M.; Palmer, Andrew J.

doi:10.1007/s00198-015-3093-2

Cited by 372 publications

(229 citation statements)

References 35 publications

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“…To assess BMD, measurements of the second to fourth lumbar vertebrae and the femur bone (neck, trochanter and the whole femur) were used. Bone density was calculated based on g/cm 2 . Statistical analyses.…”

Section: Methodsmentioning

confidence: 99%

“…For all participants, body weight (BW) and body height (BH) were measured to determine the BMI, calculated as BMI5BW (kg)/BH (m) 2 . The minimum, maximum, and mean BMI measurements for the 264 participants were 30, 46.9, and 35.3 kg/m 2 , respectively.…”

Section: Subjectsmentioning

confidence: 99%

“…The fractures caused by osteoporosis have a great impact on public health, as they are often associated with increased morbidity, mortality, reduced quality of life, long hospital stays and high economic cost (1). Consequently, cost-effective intervention policies must urgently be identified in an attempt to minimize the impact of fractures (2). Osteoporosis has been associated with various risk factors, particularly female gender (3), advanced age (4), dietary calcium (5), vitamin D status (6), obesity (7), chronic obstructive pulmonary disease (COPD) (8), stress (9), gastric bypass surgery (10,11), genetic variants (12)(13)(14), alcoholism (15) and smoking habit (16).…”

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confidence: 99%

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Vitamin D Receptor Gene Variation, Dietary Intake and Bone Mineral Density in Obese Women: A Cross Sectional Study

Moradi

Khorraminezhad

Maghbooli

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Osteoporosis and fragility fractures have been regarded as important public health concerns. We investigated their possible association with vitamin D receptor (VDR) FOK1 polymorphisms (rs10735810) and dietary parameters such as calcium and vitamin D intake. A total of 264 Iranian obese women (BMI.30 kg/m 2 ) were categorized based on the FOK1 genotype and divided into two groups: group one with the FF genotype (n5184) and the f allele carrier group with the Ff or ff genotype (n580). The body composition, dietary intake and bone mineral density were assessed for all cases. The frequency of the F and f alleles for FOK1 in the study were 71.5% and 28.5%, respectively. Women with the f allele had a higher BMI (p50.05), as well as parathyroid hormone (PTH) and tumor necrosis factor alpha (TNF-a) concentration (p50.05, p50.01, respectively). Participants with calcium intakes of more than 1,000 mg/d and the ff genotype had a higher L2_L4 Z-score. Moreover, women with vitamin D intakes of less than 600 IU/d and the ff genotype had a higher total T-score and total Z-score. Although women whose dietary intake of vitamin D was higher than the recommended dietary allowance (RDA.600 IU/d) and had the FF genotype had a higher total T-score and total Z-score, as well. Our findings suggest that interactions between FOK1 polymorphisms in Iranian obese women and dietary intake of calcium and vitamin D may play a decisive role in bone mineral density and osteoporosis among these women.

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Section: Methodsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

mentioning

confidence: 99%

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Vitamin D Receptor Gene Variation, Dietary Intake and Bone Mineral Density in Obese Women: A Cross Sectional Study

Moradi

Khorraminezhad

Maghbooli

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…China has one of the most rapidly ageing populations: the proportion of the elderly in China is projected to be a quarter of its total population by 2050 3 . Inevitably, the rising disease and economic burden of osteoporotic fractures will challenge the sustainability of the Chinese healthcare system 4 .…”

Section: Introductionmentioning

confidence: 99%

Residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women

Liu

Winzenberg

Chen

et al. 2015

Current Medical Research and Opinion

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While national data was used wherever possible, regional Chinese hip and clinical vertebral fracture incidence rates were used, wrist fracture rates were taken from a Norwegian study and calibrated to the Chinese population. Other fracture sites like tibia, humerus, ribs and pelvis were not included in the analysis, thus these risks are likely to be underestimates. Fracture risk factors other than age and sex were not included in the model. Point estimates were used for fracture incidence rates, osteoporosis prevalence and mortality rates for the general population.

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“…By 2050, half of the world's fractures will occur in Asia and mainly in China with osteoporotic fractures to reach an estimated 5.99 million. Females sustain four times the number of fractures than males [5]. Osteoporotic fractures may cause pain [6], decrease physical function, and limit daily activities [7] and lead to social isolation and emotional distress [8,9].…”

Section: Introductionmentioning

confidence: 99%

Cross-cultural adaptation and validation of the osteoporosis assessment questionnaire short version (OPAQ-SV) for Chinese osteoporotic fracture females

et al. 2015

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The Osteoporosis Assessment Questionnaire Short Version (OPAQ-SV) was cross-culturally adapted to measure health-related quality of life in Chinese osteoporotic fracture females and then validated in China for its psychometric properties. Cross-cultural adaptation, including translation of the original OPAQ-SV into Mandarin Chinese language, was performed according to published guidelines. Validation of the newly cross-culturally adapted OPAQ-SV was conducted by sampling 234 Chinese osteoporotic fracture females and also a control group of 235 Chinese osteoporotic females without fractures, producing robust content, construct, and discriminant validation results. Major categories of reliability were also met: the Cronbach alpha coefficient was 0.975, indicating good internal consistency; the test-retest reliability was 0.80; and principal component analysis resulted in a 6-factor structure explaining 75.847 % of the total variance. Further, the Comparative Fit Index result was 0.922 following the modified model confirmatory factor analysis, and the chi-squared test was 1.98. The root mean squared error of approximation was 0.078. Moreover, significant differences were revealed between females with fractures and those without fractures across all domains (p < 0.001). Overall, the newly cross-culturally adapted OPAQ-SV appears to possess adequate validity and reliability and may be utilized in clinical trials to assess the health-related quality of life in Chinese osteoporotic fracture females.

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Projection of osteoporosis-related fractures and costs in China: 2010–2050

Cited by 372 publications

References 35 publications

Vitamin D Receptor Gene Variation, Dietary Intake and Bone Mineral Density in Obese Women: A Cross Sectional Study

Vitamin D Receptor Gene Variation, Dietary Intake and Bone Mineral Density in Obese Women: A Cross Sectional Study

Residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women

Cross-cultural adaptation and validation of the osteoporosis assessment questionnaire short version (OPAQ-SV) for Chinese osteoporotic fracture females

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