Projections of nerve cells from the duodenum to the sphincter of Oddi and gallbladder of the Australian possum

Padbury, Robert; Furness, John B.; Baker, Robert A.; Toouli, James; Messenger, J. P.

doi:10.1016/0016-5085(93)90844-3

Cited by 66 publications

(50 citation statements)

References 15 publications

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“…In some possums, FB or DiI, respectively, was injected into the extraduodenal part of the SO while in some other animals both dyes were separately injected. In all the animals, retrogradely labeled neurons were found in Padbury et al 1993b, Simula 1997, Kennedy and Mawe 1998, Mawe and Kennedy 1999.…”

Section: Intrinsic Innervation Of the Sphincter Of Oddi (Fig 1)mentioning

confidence: 88%

“…NOS-and VIP-positive varicose nerve fibres were present not only within the nerve plexuses of the duodenum and SO, but also in the circular and longitudinal muscle layers. Padbury et al (1993b) have also applied retrograde tracing method combined with immunohistochemistry to investigate the distribution and chemical coding of intramural duodenal neurons projecting to the SO in the same species (the authors have also investigated the distribution of the retrogradely labeled neurons in extrinsic autonomic and sensory ganglia; these data are analyzed in the next chapter). The authors have used two fluorescent neuronal tracers, Fast Blue (FB) and 1,1'-dioctadecyl-3,3,3'-tetramethylindocarbocyanine perchlorate (DiI).…”

Section: Intrinsic Innervation Of the Sphincter Of Oddi (Fig 1)mentioning

confidence: 99%

“…To date, investigations dealing with sources of the extrinsic innervation of the SO with the use of the retrograde tracer FB have been carried out only in the Australian possum by Padbury et al (1993b). These authors have found the retrogradely labeled nerve cells in the coeliac-anterior mesenteric ganglion complex (CAMG).…”

Section: Efferent Innervationmentioning

confidence: 99%

“…Investigations involving administration of retrograde tracers such as FB and DiI to identify sources of the afferent neural input to the SO and gallbladder have been performed by Padbury et al (1993b) in the Australian possum. After injection of FB into the sphincter, they have found labeled nerve cell bodies in the bilateral nodose ganglia of the vagus nerve, and in dorsal root ganglia (Th8-Th10).…”

Section: Afferent Innervationmentioning

confidence: 99%

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The distribution and chemical coding of neurons supplying the sphincter of Oddi in mammals

Tomaszewska¹,

Kaleczyc²

2013

Polish Journal of Veterinary Sciences

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The major duodenal papilla (papilla of Vater) is an important structure associated with the biliary tract and, in some species, the pancreas. It usually represents a slight elevation on the intestinal mucosa where the dilated junction (ampulla of Vater) of the commmon bile duct and pancreatic duct enters the duodenum. The ampulla is surrounded by a specifically arranged muscle structure called the sphincter of Oddi (SO) which controls the flow of bile and pancreatic fluid. The function of the sphincter is regulated by a complex system that involves many hormonal and neural factors. The literature in the field contains detailed data on the morphology of the SO in a number of mammalian species. However, the comprehensive information about the anatomy and neurochemistry of the innervation of this structure is very limited. The present review article summarizes the current knowledge on the innervation of the SO in mammals. Special emphasis has been put on the localization and chemical coding of neurons contributing to this nerve supply.

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Section: Intrinsic Innervation Of the Sphincter Of Oddi (Fig 1)mentioning

confidence: 88%

Section: Intrinsic Innervation Of the Sphincter Of Oddi (Fig 1)mentioning

confidence: 99%

Section: Efferent Innervationmentioning

confidence: 99%

Section: Afferent Innervationmentioning

confidence: 99%

See 2 more Smart Citations

The distribution and chemical coding of neurons supplying the sphincter of Oddi in mammals

Tomaszewska¹,

Kaleczyc²

2013

Polish Journal of Veterinary Sciences

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“…Further historical perspective is provided by Sutherland [ 3 ]. The anatomical and functional aspects of the innervation of the biliary tract are based on extensive studies in the guinea pigs [4][5][6][7][8] and the Australian brush-tailed possum [ 9,10 ]. A nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemical technique that relies on certain neurons possessing an enzyme that catalyzes the NADPH-dependent conversion of a soluble tetrazolium salt to an insoluble visible formazan [ 11,12 ] is used to identify neurons that utilize nitric oxide.…”

mentioning

confidence: 99%

Distribution of NADPH-diaphorase Positive Ganglionated Plexuses in Porcine Gall Bladder

Stefanov¹,

Vodenicharov²

2013

Proceeding BAS

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The distribution and dimensions of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) positive ganglia in the domestic pig's gall bladder and Ductus cysticus were studied for the first time. It was established that the number of ganglia was highest in the gall bladder's body, followed by those in the fundus and neck. The lowest number of ganglia was observed in Ductus cysticus. The largest ganglia were localized in the gall bladder's neck, followed by these in the body and fundus. The highest density of neurons per ganglion was detected in the neck, followed by body and fundus. Their number, however, was the lowest in the ganglia of Ductus cysticus. The largest neurons were established in the gall bladder's neck.It was concluded that the NADPH-d ganglia as neuronal structures produce nitric oxide, which as a transmitter with neuronal origin most probably is involved in the control of the epithelial secretion and in the function of smooth muscle in the walls of both gall bladder and blood vessels as well.

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Chemical coding of intrinsic and extrinsic nerves in the guinea pig gallbladder: Distributions of PACAP and orphanin FQ

Mawe

Ellis

2001

Anat. Rec.

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Projections of nerve cells from the duodenum to the sphincter of Oddi and gallbladder of the Australian possum

Cited by 66 publications

References 15 publications

The distribution and chemical coding of neurons supplying the sphincter of Oddi in mammals

The distribution and chemical coding of neurons supplying the sphincter of Oddi in mammals

Distribution of NADPH-diaphorase Positive Ganglionated Plexuses in Porcine Gall Bladder

Chemical coding of intrinsic and extrinsic nerves in the guinea pig gallbladder: Distributions of PACAP and orphanin FQ

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