Prokinetic effect of indoramin, an α‐adrenergic antagonist, on human gall‐bladder

Abstract

SUMMARYBackground: The effects of a-and b-adrenergic agents on gall-bladder motility remain undefined. Aim: To determine the effects of a-and b-antagonists on gall-bladder motility in healthy humans. Methods: In this single, blind, three-way crossover study, a slow-release formulation of propranolol 80 mg (b-antagonist), indoramin 25 mg (post-synaptic a 1 -antagonist) and placebo were administered to 10 healthy volunteers on three separate days 8 h before the assessment of gall-bladder volumes by ultrasonography. Gall-bladder volumes were assessed in the fasting state and at 5-min intervals for 50 min after a standard proprietary enteral feed (Ensure 186 mL, Abbott).

Low fat-containing elemental formula is effective for postoperative recovery and potentially useful for preventing chyle leak during postoperative early enteral nutrition after esophagectomy

“…Postoperative EN is generally administered in our department for patients undergoing jejunostomy performed simultaneously with esophageal surgery. In this study, patients were retrospectively divided into two groups based on the EN formula administered: Group F contained the patients who started EN with a standard fatcontaining polymeric formula (ENSURE LIQUID ® ; Abbott Japan Co., Ltd., Tokyo, Japan [11], RACOL ® ; Ohtsuka Chemical Industrial Co., Ltd., Tokushima, Japan [12], or IMPACT ® , Ajimonoto Co., Inc., Tokyo, Japan [13]); and Group LF contained the patients who started EN with a low-fat elemental formula (ELENTAL ® ; Ajimonoto Pharmaceuticals Co., Ltd., Tokyo, Japan [14]). Each EN formula provides energy as 1 kcal/ml, and the composition of carbohydrate, protein or amino acid, and fat are detailed in Table 1.…”

Tegaserod Does not Alter Fasting or Meal-Induced Biliary Tract Motility

“…The gallbladder expresses α-, β 1 -, and β 3 -adrenergic receptors (8). Treatment with the postsynaptic α 1 -antagonist indoramin enhances postprandial gallbladder emptying in humans (9). There is no direct evidence suggesting the presence of functional 5-HT 4 receptors in the gallbladder or biliary tract, and their absence in the sphincter of Oddi has been confirmed (10).…”