Prolactin and Hypercalcæmia

Mahajan, Kusum; Robinson, Christopher; Horrobin, David F.

doi:10.1016/s0140-6736(74)91061-7

Cited by 22 publications

(9 citation statements)

References 5 publications

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“…It has been suggested that prolactin may be responsible for the hypercalcaemia that occurs in some forms of breast malignancy [Mahajan et al, 1974]. However, in view of the present results it would appear unlikely that disordered prolactin regulation in women with breast cancer can be solely responsible for the hypercalcaemia that may occur.…”

Section: Discussioncontrasting

confidence: 46%

“…The work of Spanos, Pike, Haussler, Colston, Evans, Goldner, McCain and Maclntyre, [1976] indicates that prolactin may modulate vitamin D metabolism in the chick. Furthermore, many of the metabolic effects of prolactin are similar to those of growth hormone which is known to play a role in calcium metabolism [McGarry and Beck, 1972].Although the studies of Mahajan et al [1974] show that acute elevation of prolactin may influence the blood calcium levels, it has been shown that normal circulating levels of prolactin do not affect blood calcium homeostasis in the rat [Tan and Tan, 1978]. Physiologically, circulating prolactin levels become markedly elevated during pregnancy and lactation [Amenomori, Chen and Meites, 1970] and it has recently been suggested that prolactin may play a major role in producing the changes in vitamin D and calcium metabolism that occur during these states [Anon., 1977].…”

mentioning

confidence: 99%

“…In the rat, acute infusion of a low dose of prolactin results in hypercalcaemia and hypercalciuria [Mahajan, Robinson and Horrobin, 1974]. Prolactin administration to rats has also been reported to increase intestinal calcium absorption [James, Makeen, Foley, Stevens and Robinson, 1977].…”

mentioning

confidence: 99%

“…Although the studies of Mahajan et al [1974] show that acute elevation of prolactin may influence the blood calcium levels, it has been shown that normal circulating levels of prolactin do not affect blood calcium homeostasis in the rat [Tan and Tan, 1978]. Physiologically, circulating prolactin levels become markedly elevated during pregnancy and lactation [Amenomori, Chen and Meites, 1970] and it has recently been suggested that prolactin may play a major role in producing the changes in vitamin D and calcium metabolism that occur during these states [Anon., 1977].…”

mentioning

confidence: 99%

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Maintenance of Normal Serum Calcium Level in the Hyperprolactinaemic Rat

Tan

1979

Exp Physiol

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The effect of experimentally induced chronic hyperprolactinaemia in male rats on the serum levels of calcium has been examined. Chronic elevation of circulating prolactin levels had no significant effect on the serum calcium levels and normal blood calcium homeostasis was still maintained.There is evidence that prolactin is involved in calcium metabolism. In the rat, acute infusion of a low dose of prolactin results in hypercalcaemia and hypercalciuria [Mahajan, Robinson and Horrobin, 1974]. Prolactin administration to rats has also been reported to increase intestinal calcium absorption [James, Makeen, Foley, Stevens and Robinson, 1977]. The work of Spanos, Pike, Haussler, Colston, Evans, Goldner, McCain and Maclntyre, [1976] indicates that prolactin may modulate vitamin D metabolism in the chick. Furthermore, many of the metabolic effects of prolactin are similar to those of growth hormone which is known to play a role in calcium metabolism [McGarry and Beck, 1972].Although the studies of Mahajan et al. [1974] show that acute elevation of prolactin may influence the blood calcium levels, it has been shown that normal circulating levels of prolactin do not affect blood calcium homeostasis in the rat [Tan and Tan, 1978]. Physiologically, circulating prolactin levels become markedly elevated during pregnancy and lactation [Amenomori, Chen and Meites, 1970] and it has recently been suggested that prolactin may play a major role in producing the changes in vitamin D and calcium metabolism that occur during these states [Anon., 1977].In view of the possible important relationship between prolactin and calcium metabolism, we have undertaken an investigation of the long term effects of hyperprolactinaemia on blood calcium homeostasis in the rat. MethodsIn a preliminary study, chronic elevation of prolactin was induced in male rats by subcutaneous injection of perphenazine [Schering, Code 991571]

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Section: Discussioncontrasting

confidence: 46%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Maintenance of Normal Serum Calcium Level in the Hyperprolactinaemic Rat

Tan

1979

Exp Physiol

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“…This has been demonstrated in rats (Lewis et al, 1971 ; Taylor, Lewis and Balderstone, 1975), goats and women (Stevenson, Hillyard and Maclntyre, 1979). Among the hormones involved in the regulation of calcium (Ca) metabolism, ovine prolactin (PRL) infused into intact male rats (10 jig per rat per h for 18 h) has been reported to induce a significant increase in plasma Ca concentration (Mahajan, Robinson and Horrobin, 1974). Similarly, ovine PRL injected into intact male rats (1-2 mg per rat daily for 2 days) increased significantly Ca transport across everted jejunal sacs (Mainoya, 1975).…”

Section: Introductionmentioning

confidence: 99%

Calcitonin treatment and plasma prolactin levels in pregnant and lactating ewes

Barlet¹,

Ravault²

1984

Reprod. Nutr. Dévelop.

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Summary. The intravenous injection of a physiological dose of salmon calcitonin (0.5 wg/kg bw) in 5 ewes on day 125 of gestation induced a slight but significant hypocalcaemia. It had no significant effect on plasma prolactin levels.Ten days after parturition the same dose of salmon calcitonin given in a similar manner to 5 ewes has no effect on suckling-induced prolactin release, although it significantly decreased plasma calcium concentration.This demonstrates that short-term changes in plasma calcitonin concentration have no effect on basal plasma prolactin concentration or on suckling-induced prolactin surge in ewes.Introduction.

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Pituitary stimulation of parathyroid hormone secretion: Evidence in cattle for a parathyroid stimulating hormone

Latman

1980

J. Exp. Zool.

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A number of previous investigations have indicated that the pituitary may directly stimulate secretion of parathyroid hormone. Others have disagreed. With the recent development of an in vitro bovine parathyroid perfusion system, the direct effect of suspected secretagogues can be assessed on a dynamic, ongoing basis. A partially purified pituitary extract (preparation A) was injected into calves. The plasma calcium increased an average of 1.1 mg/100 ml plasma. No increase of immunoreactive parathyroid hormone (iPTH) was detected, however, in the peripheral plasma prior to the increase in plasma calcium concentration. Since the peripheral plasma iPTH concentration has been shown to be relatively insensitive to changes in the secretion rate, the inability to detect a change in the iPTH concentration does not preclude a direct stimulating effect of the pituitary on the parathyroid. When preparation A was tested on in vitro perfused bovine parathyroid glands, a 30% average increase in secretion of c-iPTH (carboxy terminus) and a 56% average increase in secretion of n-iPTH (amino terminus) was observed under normocalcemic conditions. Under conditions of hypercalcemia, there was an average increase in the c-iPTH secretion rate of 60% and an average n-iPTH secretion rate increase of 88%. A failure of TSH, LH, GH, ADH, oxytocin, and prolactin to stimulate iPTH was observed. Previous reports have eliminated ACTH, MSH, and lipotropin as possible parathyroid secretagogues. The concept of a parathyroid stimulating hormone (PTSH) located in the pituitary that can directly stimulate the parathyroid gland to secrete parathyroid hormone is consistent with the results of this investigation.

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Prolactin and Hypercalcæmia

Cited by 22 publications

References 5 publications

Maintenance of Normal Serum Calcium Level in the Hyperprolactinaemic Rat

Maintenance of Normal Serum Calcium Level in the Hyperprolactinaemic Rat

Calcitonin treatment and plasma prolactin levels in pregnant and lactating ewes

Pituitary stimulation of parathyroid hormone secretion: Evidence in cattle for a parathyroid stimulating hormone

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