Prolactin-Induced Regression of the Rat Corpus Luteum: Expression of Monocyte Chemoattractant Protein-1 and Invasion of Macrophages1

Bowen, J. M.; Keyes, P. Landis; Warren, John Robert; Townson, David H.

doi:10.1095/biolreprod54.5.1120

Cited by 101 publications

(75 citation statements)

References 50 publications

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“…In rodents, prostaglandin F2a (PGF-2a) is a uterine-derived factor that initiates luteolysis. In addition, the preovulatory prolactin (PRL) surge in the evening of proestrus is presumed to initiate the regression of the CL from the preceding cycle (Bowen et al 1996, Gaytan et al 1998. However, it is also well known that in lactating rats PRL has a luteotropic effect on luteal cells (Goyeneche et al 2003), suggesting a dual effect of this hormone on this cell type.…”

Section: Introductionmentioning

confidence: 99%

Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle

Peluffo¹,

Bussmann²,

Stouffer³

et al. 2006

Reproduction

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Apoptosis is associated with the regression of the corpus luteum (CL) in many species. Since caspases play a central role in apoptosis, we studied several initiators (-2, -8, and -9) and the main effector (-3) caspase in the CL during the estrous cycle of the rat. Two different populations of CL (old and new) were identified on ovaries at estrus and diestrus II (DII). Diminished (P!0.05) luteal progesterone content and P450scc levels suggested that functional luteolysis occurred between the new CL at DII and old CL at estrus, whereas the decline (P!0.05) in luteal weight indicated that structural regression was occurring between old CL at estrus to DII. Immunostaining for caspase-2 in luteal and endothelial cells appeared to increase as the luteal phase progressed, peaking at DII in the old CL. However, caspase-8 and -9 immunostaining showed little change with a slight increase at estrus in the old population. Notably, caspase-3 staining appeared to peak at DII in the new CL. Enzyme activity of caspase-9 increased (P!0.05) in the new CL at DII, followed by that of caspase-2 and -3 in old CL at estrus. Caspase-8 activity did not change at any stage. The number of apoptotic cells increased at DII in the old CL. These results suggest an important role for this protease family during early events of luteolysis in the rat estrous cycle. Reproduction (2006) 132 465-475

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Section: Introductionmentioning

confidence: 99%

Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle

Peluffo¹,

Bussmann²,

Stouffer³

et al. 2006

Reproduction

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“…Previous studies have demonstrated that PRL shows specific roles in ovarian function, such as its luteotropic effect on newly formed corpora lutea [6] and luteolytic effect on aged corpora lutea in rats [30]. A PRL surge occurs during the periovulatory period [1,29,31,32] and induces apoptosis of lutein cells and structural luteolysis when the corpus luteum ceases progesterone production in rats [4,6,8,15,30].…”

mentioning

confidence: 99%

Prolactin Secretion and Ovarian Function in Cycling and Non-Cycling African Female Elephants (Loxodonta africana)

Yamamoto

Watanabe

et al. 2010

J. Vet. Med. Sci.

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ABSTRACT. Reproduction of captive elephants in zoos has shown a low fecundity and requires improvement. One of the reasons for low fecundity is ovarian dysfunction in many female elephants. To investigate whether prolactin has a correlation with ovarian function in female elephants, the serum concentrations of prolactin, progesterone and estradiol-17 in four African female elephants (one cycling female and three non-cycling female elephants) were measured. Cyclic patterns of prolactin and estradiol-17 were observed in the cycling female elephant, which tended to be high during the follicular phase and low during the luteal phase. On the other hand, a cyclic pattern of prolactin was not observed in the non-cycling female elephants. One of the three non-cycling females (Mako) had developed breasts and showed significantly higher average levels of prolactin than the other female elephants. These results suggested that high concentrations of circulating estradiol-17 during the follicular phase stimulated prolactin secretion. They also suggested that hyperprolactinemia in Mako was one of the causes of the developed mammary glands and ovarian dysfunction.

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“…However, several studies showed that depletion of peripheral blood leukocytes, mainly neutrophils, did not affect ovulation (14). Ovarian macrophages have been postulated as another candidate that may be involved in ovulation (4,29,30). The present study suggests that a unique population of CD8␣␣ ϩ cells in the theca of antral follicles, but not macrophages, may be a more likely candidate for their involvement in ovulation.…”

Section: Discussionmentioning

confidence: 45%

“…2D). The invasion of macrophages into corpora lutea has been reported (29). Those results suggest that macrophages may play roles in luteinization but not ovulation.…”

Section: Influx Of Cd8␣␣ ϩ Cells Into Ovaries During Hcg-induced Ovulmentioning

confidence: 88%

Potential Roles of a Special CD8αα+ Cell Population and CC Chemokine Thymus-Expressed Chemokine in Ovulation Related Inflammation

Zhou

Wu²,

Borillo³

et al. 2009

The Journal of Immunology

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It is well known that ovulation may be an inflammatory process. However, it remains elusive how immune cells participate in this process. We have identified a novel CD8αα+ population, which resembles tissue dendritic cells, in the theca of antral follicles. We further observed a dramatic influx of the CD8αα+cells into the ovulating follicles. This CD8αα+population was absent in the ovary of estradiol-induced anovulatory C31F1 mice and subfertile athymic nude mice. Expression of a CC chemokine thymus-expressed chemokine (TECK) has previously been found in the ovary; we further demonstrated that TECK attracted CD8αα+cells into the ovary. Anti-TECK Ab, elicited in the female mice by active immunization, depleted the ovarian CD8αα+ cells in vivo. Mice with a high titer of TECK Ab failed to ovulate after superovulation induction. More importantly, the immunized mice had greatly reduced fertility, which was positively correlated with the Ab titers. Ovarian TECK expression was normal in anovulatory C31F1 mice, suggesting that infertility in the immunized mice is due to a block of CD8αα+ cell migration. Finally, the origin of ovarian CD8αα+ cells was explored. Upon being transferred, thymic CD8α+ cells were able to home to the theca of follicles in the recipients. Thus, ovarian CD8αα+ cells, which participate in the ovulation-related inflammation, may originate in the thymus.

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Prolactin-Induced Regression of the Rat Corpus Luteum: Expression of Monocyte Chemoattractant Protein-1 and Invasion of Macrophages1

Cited by 101 publications

References 50 publications

Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle

Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle

Prolactin Secretion and Ovarian Function in Cycling and Non-Cycling African Female Elephants (Loxodonta africana)

Potential Roles of a Special CD8αα+ Cell Population and CC Chemokine Thymus-Expressed Chemokine in Ovulation Related Inflammation

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