Prolactin secretion in response to prolactin-releasing peptide and the expression of the prolactin-releasing peptide gene in the medulla oblongata are estrogen dependent in rats

Tokita, Reiko; Nakata, T.; Katsumata, Harumi; Konishi, Shunichiro; Onodera, Hidetaka; Imaki, Junko; Minami, Shiro

doi:10.1016/s0304-3940(99)00796-x

Cited by 55 publications

(22 citation statements)

References 15 publications

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“…The estrogen-primed animal model used in this study appears to be appropriate for PrRP. This finding confirms some previous studies [22], but not others [13,36].…”

Section: Discussionsupporting

confidence: 93%

“…injection of PrRP induced significant PRL secretion in anesthetized female rats at various estrous stages [22], or on estrus alone [36]. Furthermore, one study [22] also showed a positive PRL response in the male rat (less than that in the female), while another [36] found no effect in the male and in proestrous or diestrous female rats. Another study [13] found no effect at all in both conscious male and lactating female rats.…”

Section: Introductionmentioning

confidence: 92%

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Effects of Prolactin-Releasing Peptide on Tuberoinfundibular Dopaminergic Neuronal Activity and Prolactin Secretion in Estrogen-Treated Female Rats

Yuan¹,

Yang²,

Pan³

2002

J Biomed Sci

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Both systemic and central effects of a newly discovered prolactin (PRL)-releasing factor (PRF), prolactin-releasing peptide (PrRP), were determined in this study. Systemic injection of PrRP (1 and 10 µg/rat, i.v.) stimulated PRL secretion in ovariectomized, estrogen-treated rats similar to the effect of another PRF, thyrotropin-releasing hormone (TRH). Pretreatment with a dopamine D₂ receptor antagonist, sulpiride (1 µg/rat, i.v.), potentiated the stimulatory effect of both PrRP and TRH on PRL secretion. Using the double-labeling immunohistochemical method, PrRP-immunoreactive terminals were found in close contact with tyrosine-hydroxylase-immunoreactive neurons in the hypothalamic arcuate nucleus. Central administration of PrRP (0.1–1,000 ng/rat, i.c.v.) stimulated tuberoinfundibular but not nigrostriatal dopaminergic neuronal activity in 15 min. Levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence and striatum were used as indices for tuberoinfundibular dopaminergic (TIDA) and nigrostriatal dopaminergic neuronal activities, respectively. The serum PRL level, however, was not significantly changed. Similar treatment with TRH (10 ng/rat, i.c.v.) stimulated and inhibited TIDA neuronal activity and serum PRL, respectively, at 30 min. In summary, PrRP may play a role in both the central and peripheral control of PRL secretion.

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“…The estrogen-primed animal model used in this study appears to be appropriate for PrRP. This finding confirms some previous studies [22], but not others [13,36].…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 92%

Effects of Prolactin-Releasing Peptide on Tuberoinfundibular Dopaminergic Neuronal Activity and Prolactin Secretion in Estrogen-Treated Female Rats

Yuan¹,

Yang²,

Pan³

2002

J Biomed Sci

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“…There are several previous studies which reported an excitatory action of PrRP on PRL release in vivo (8,9) and in vitro (1,17), although conflicting reports also exist (10,11). However, to the best of our knowledge, the present study is the first to have examined a possible role for PrRP in the generation of ovarian steroidinduced LH and PRL surges in the rat.…”

Section: Discussionmentioning

confidence: 60%

“…Although iv administration of PrRP has been reported to stimulate PRL secretion in both male and female rats, in males a pharmacologically high dose of the peptide was required to induce the hormonal response (8). Other researchers also reported similar data that the PRLreleasing potency of PrRP31 in vivo was much weaker than that of thyrotropin-releasing hormone (9), and another study in vivo even concluded that PrRP is unable to stimulate PRL secretion (10). In addition, by using anterior pituitary cell culture in vitro, Samson et al (11) reported that the PRL-releasing activities of both PrRP31 and PrRP20 were not demonstrable in male rats, and very weak even in female rats.…”

mentioning

confidence: 92%

Involvement of Prolactin-Releasing Peptide in the Preovulatory Luteinizing Hormone and Prolactin Surges in the Rat

Hizume

Watanobe

Yoneda

et al. 2000

Biochemical and Biophysical Research Communications

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“…Immunoreactive PrRP can be detected in rat hypothalamus in very high concentrations [2], and a high density of PrRP receptor mRNA has been detected in the anterior pituitary of the rat [1, 3, 4]. Although these biochemical characteristics of PrRP may support the concept that the neuropeptide is a reasonable candidate for a physiological PRL-releasing factor, a number of in vivo [5, 6, 7, 8]and in vitro [9]studies conducted to date have argued against this possibility. However, this author and coworkers recently reported that PrRP may play a significant role in mediating the steroid induced PRL surge in the rat [10].…”

Section: Introductionmentioning

confidence: 99%

In vivo Release of Prolactin-Releasing Peptide in Rat Hypothalamus in Association with Luteinizing Hormone and Prolactin Surges

Watanobe

2001

Neuroendocrinology

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Prolactin (PRL)-releasing peptide (PrRP) is a novel hypothalamic peptide reported to be a potent and specific stimulator of PRL secretion. This author recently reported that PrRP might play a significant role in mediating the steroid-induced PRL surge in the rat. In order to examine the secretory profile of PrRP in the rat hypothalamus before and during the luteinizing hormone (LH) and PRL surges, this study employed the push-pull perfusion technique and determined the in vivo release of PrRP and also of gonadotropin-releasing hormone (GnRH) in ovariectomized rats primed with estradiol and progesterone. In the medial preoptic area (MPOA) where the GnRH neuronal perikarya exist, GnRH release was increased prior to the initiation of the LH surge, and PrRP also started rising even earlier than GnRH. In the median eminence-arcuate nucleus complex (ME-ARC), where GnRH neuronal fibers terminate, GnRH secretion started increasing before the commencement of the LH surge, but the release of PrRP did not change significantly. These results suggest that PrRP may play a role in mediating the steroid-induced LH surge by activating GnRH neurons in the MPOA. A possible involvement of PrRP in the PRL surge was not suggested from the present data. The lack of a significant alteration in PrRP release in the ME-ARC may argue against a direct hypophysiotropic action of the peptide.

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Prolactin secretion in response to prolactin-releasing peptide and the expression of the prolactin-releasing peptide gene in the medulla oblongata are estrogen dependent in rats

Cited by 55 publications

References 15 publications

Effects of Prolactin-Releasing Peptide on Tuberoinfundibular Dopaminergic Neuronal Activity and Prolactin Secretion in Estrogen-Treated Female Rats

Effects of Prolactin-Releasing Peptide on Tuberoinfundibular Dopaminergic Neuronal Activity and Prolactin Secretion in Estrogen-Treated Female Rats

Involvement of Prolactin-Releasing Peptide in the Preovulatory Luteinizing Hormone and Prolactin Surges in the Rat

In vivo Release of Prolactin-Releasing Peptide in Rat Hypothalamus in Association with Luteinizing Hormone and Prolactin Surges

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