Prolaps Organ Panggul

Wibisono, Jacobus Jeno; Hermawan, Gezta Nasafir

doi:10.19166/med.v7i1.1444

“…The decrease in the hormone estrogen results in atrophy of the genital tract organs, weakening of the pelvic floor muscles, weakening of the uterosacral and cardinal ligaments, weakening of the endopelvic fascia to stretch, and easy pelvic organ prolapse. [9][10][11] Menopause causes a decrease in the hormone estrogen, resulting in tissue weakness due to changes in the synthesis and degradation of extracellular matrix proteins, which this proteins help in tissue stability and keep collagen from being degraded. This can be caused by the reduced production of estrogen caused by menopause, resulting in reduced expression of type I collagen, which has elastic properties and has a significant and robust resistance to tension and increased expression of type III collagen, which has the role of increasing tissue elasticity and stretch, resulting in decreased strength in supporting pelvic floor organs in pelvic organ prolapse patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors with the Degree of Pelvic Organs Prolapse at Dr. Mohammad Hoesin General Hospital Palembang

Putra

¹

,

Aidi

²

,

Zulkarnain

³

2021

bsm

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Background. Pelvic organ prolapse (POP) is a condition in which one or more pelvic organs (consisting of the uterus, vaginal cuff, bladder, intestines, and rectum) or more are still in or out of the vagina. Risk factors that influence the incidence of POP consist of obstetric risk factors (number of parity and birth method) and non-obstetric risk factors (age, menopause, BMI, comorbid disease, and hypertension). The purpose of this study was to analyze the risk factors associated with the degree of POP. Methods. This study is an observational study with a cross-sectional approach to 111 patients examined at the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin general hospital Palembang on January 2017 to December 2019, who was diagnosed with pelvic organ prolapse. Results. The results showed the effect of variables with the degree of POP using the chi-square test, consisting of parity (p=0.007), birth method (p=<0.001), age (p=0.016), menopause (p=0.001), BMI (p =0.005), indicates that there is a significant effect on the degree of POP. Meanwhile, comorbid factors (p=0.481) and hypertension (p=0.415) did not show a significant relationship with the degree of POP. The results of the binary logistic regression analysis of all risk factors, the number of parity >4, overweight, and age 40 years, will have a 99.85% chance of experiencing grade 3 or 4 prolapse. Conclusion. Age is the most dominant risk factor affecting the degree of pelvic organ prolapse, with 19 times the chance of developing POP 3 or 4 degrees.

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“…The decrease in the hormone estrogen results in atrophy of the genital tract organs, weakening of the pelvic floor muscles, weakening of the uterosacral and cardinal ligaments, weakening of the endopelvic fascia to stretch, and easy pelvic organ prolapse. [9][10][11] Menopause causes a decrease in the hormone estrogen, resulting in tissue weakness due to changes in the synthesis and degradation of extracellular matrix proteins, which this proteins help in tissue stability and keep collagen from being degraded. This can be caused by the reduced production of estrogen caused by menopause, resulting in reduced expression of type I collagen, which has elastic properties and has a significant and robust resistance to tension and increased expression of type III collagen, which has the role of increasing tissue elasticity and stretch, resulting in decreased strength in supporting pelvic floor organs in pelvic organ prolapse patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors with the Degree of Pelvic Organs Prolapse at Dr. Mohammad Hoesin General Hospital Palembang

Putra

¹

,

Aidi

²

,

Zulkarnain

³

2021

Bioscmed

1

0

View full text Add to dashboard Cite

Background. Pelvic organ prolapse (POP) is a condition in which one or more pelvic organs (consisting of the uterus, vaginal cuff, bladder, intestines, and rectum) or more are still in or out of the vagina. Risk factors that influence the incidence of POP consist of obstetric risk factors (number of parity and birth method) and non-obstetric risk factors (age, menopause, BMI, comorbid disease, and hypertension). The purpose of this study was to analyze the risk factors associated with the degree of POP. Methods. This study is an observational study with a cross-sectional approach to 111 patients examined at the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin general hospital Palembang on January 2017 to December 2019, who was diagnosed with pelvic organ prolapse. Results. The results showed the effect of variables with the degree of POP using the chi-square test, consisting of parity (p=0.007), birth method (p=<0.001), age (p=0.016), menopause (p=0.001), BMI (p =0.005), indicates that there is a significant effect on the degree of POP. Meanwhile, comorbid factors (p=0.481) and hypertension (p=0.415) did not show a significant relationship with the degree of POP. The results of the binary logistic regression analysis of all risk factors, the number of parity >4, overweight, and age 40 years, will have a 99.85% chance of experiencing grade 3 or 4 prolapse. Conclusion. Age is the most dominant risk factor affecting the degree of pelvic organ prolapse, with 19 times the chance of developing POP 3 or 4 degrees.

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“…4 Every case of POP is always based on weakness in the pelvic floor support, which is associated with repeated damage to muscles and connective tissue due to the process of repeated stretching and relaxation during pregnancy and childbirth. 5,6 This supporting function is influenced by the components of the connective tissue's extracellular matrix, which are mainly collagen types I and III. Biochemical changes in collagen can be influenced by matrix metalloproteinase (MMP) activity which plays an important role in the tissue remodeling process.…”

Section: Introductionmentioning

confidence: 99%

The Matrix Metalloproteinase-9 Gene Polymorphisms as Risk Factor for Pelvic Organ Prolapse in Balinese Women

Mahendra¹,

Widayana²,

Putra³

et al. 2023

Journal of South Asian Federation of Obstetrics and Gynaecology

1

0

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Aim: Pelvic organ prolapse (POP), although not life-threatening, is a serious condition that can affect a patient's quality of life. As life expectancy rises, the number of women with POP continues to rise. The weakness of the pelvic floor is always found underlying each case of POP. This weakness in the pelvic floor is associated with repeated damage to muscles and connective tissue due to the process during pregnancy and delivery. Balinese women have risk factors for developing POP related to the obligation to continue their offspring by conceiving and giving birth more than 4 times and working as heavy workers. The presence of genetic factors is also thought to play a role as a risk factor for POP in Balinese women. The purpose of this study was to prove the existence of polymorphism matrix metalloproteinase-9 (MMP-9) rs17576 as a factor that puts Balinese women at risk for POP. Materials and methods: A paired case-control study was conducted on each of 30 Balinese women with POP and without prolapse, which was done matching based on parity and occupation variables at

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Prolaps Organ Panggul

Cited by 6 publications

References 0 publications

Analysis of Risk Factors with the Degree of Pelvic Organs Prolapse at Dr. Mohammad Hoesin General Hospital Palembang

Analysis of Risk Factors with the Degree of Pelvic Organs Prolapse at Dr. Mohammad Hoesin General Hospital Palembang

Analysis of Risk Factors with the Degree of Pelvic Organs Prolapse at Dr. Mohammad Hoesin General Hospital Palembang

The Matrix Metalloproteinase-9 Gene Polymorphisms as Risk Factor for Pelvic Organ Prolapse in Balinese Women

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