Prolidase and Oxidative Stress in Chronic Hepatitis C

Abstract

Background Hepatitis C infection represents a common healthcare issue worldwide. The present trial was designed to investigate the role of prolidase, an enzyme that is significantly involved in the biosynthesis of collagen, and of the oxidative stress that is considered to be involved in the pathogenesis of various diseases, in the chronic hepatitis C infection. The trial was performed to assess the serum prolidase enzyme level and the oxidative–antioxidative status and to determine the relation between the serum prolidase activity and the oxidative stress parameters. Methods A total of 95 individuals, including 55 patients with chronic hepatitis C infection (CHC) and 40 healthy adults, were enrolled in the trial. The values for prolidase, the total antioxidant status (TAS), the total oxidative stress (TOS), the oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation LOOH, catalase (CAT), and ceruloplasmin were measured and compared between the patient groups. Results The prolidase, TOS, LOOH, CAT, and the OSI values were higher in the chronic hepatitis C group compared to the control group (P < 0.001). The TAS, SH, and ceruloplasmin levels were lower in the CHC group relative to the control group (P < 0.001). Conclusion We suppose that the values of prolidase and the oxidative stress are increased while the antioxidant levels are decreased in CHC. As a result, prolidase and the oxidative stress seem to be related with the progression of the disease. J. Clin. Lab. Anal. 26:232‐237, 2012. © 2012 Wiley Periodicals, Inc.

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

“…Moreover, there are few studies that have revealed a correlation between the serum prolidase levels and stage of liver fibrosis according to the results of liver biopsy [24,[28][29][30] . In contrast, Duygu et al [22,23] did not observe a relationship between the degree of liver fibrosis and serum prolidase levels in patients with chronic hepatitis B and C. In this study, we observed a significant difference when the prolidase levels in cirrhosis patients were compared with patients with HCC. This might indicate enhanced turnover of collagen synthesis in patients with HCC, which can be affected by the degree of neoplastic transformation during the development of HCC, on the basis of the cirrhotic process.…”

“…In another study, Myara et al [11] demonstrated increased prolidase activity in chronic liver disease. Elevated prolidase levels in some common conditions, such as hepatitis B infection, hepatitis C infection, nonalcoholic steatohepatitis and alcoholic liver disease, which cause hepatic damage and hepatic fibrosis, have also been reported previously [22][23][24][25] . Although numerous non-invasive markers have been described that predict the severity of hepatic fibrosis [26] , liver biopsy remains a gold standard method for assessing the severity of liver fibrosis and cirrhosis [27] .…”

Prolidase

“…Duygu et al suggested that the values of prolidase and the oxidative stress are increased while the antioxidant levels are decreased in chronic hepatitis C and they proposed that prolidase enzyme and oxidative damage might have an association with the HCV infection becoming chronic (35).…”

Serum levels of prolidase and ischemia modified albumin in patients with multiple sclerosis

“…9 Prolidaz (E.C.3.4.13.9) kollajen biyosentezinde rol alan matriks metalloproteinaz ailesine dahil bir enzimdir. 10 Prolidaz aktivitesi, plazma, eritrosit ve lökositlerde, hem de karaciğer hastalıkları, 10 …”